Publications by authors named "Yan-Yun Zhang"

The species has been included in . This caused us to reconsider the relationships between and the lecanorine species of and to question the monophyly of . Amongst 25 genera of the family Lecideaceae, most have lecideine apothecia, the exceptions being and , which have lecanorine apothecia.

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Objective: Alzheimer's disease (AD) is a common neurodegenerative disease. This study was designed to investigate the roles of lncRNA NEAT1/miR-27a-3p axis in AD.

Methods: Amyloid protein was used to treat SH-SY5Y cells and rats to construct AD model.

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This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).

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Article Synopsis
  • Two pectic polysaccharides, CPP-1 and CTP-1, were extracted from the roots of Codonopsis pilosula and Codonopsis tangshen using boiling water and chromatography.
  • Both polysaccharides share a similar backbone structure but differ in molecular weight and composition, which affects their antioxidant properties.
  • The study suggests that CPP-1 and CTP-1 have potential as natural antioxidants, highlighting their value for future health product developments.
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  • * PGP-I-I is primarily composed of 1,5-α-L-arabinan, and includes arabinogalactan chains linked to a rhamnogalacturonan I backbone, which is further connected to longer galacturonan chains.
  • * In vitro studies indicate that PGP-I-I enhances intestinal cellular antioxidant defenses under hydrogen peroxide stress by increasing the expression of antioxidant genes, thereby mitigating oxidative damage.
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Accumulating data manifest that long non-coding RNA (lncRNAs) are involved in all kinds of neurodegenerative disorders, consisting of the onset and progression of Alzheimer's disease (AD). The study was for the research of the mechanism of lncRNA H19 (H19) in viability and apoptosis of PC12 cells induced by Aβ in a cellular model of AD with the regulation of microRNA (miR)-129 and high mobility group box-1 protein (HMGB1). An AD cellular model of PC12 cells was established using Aβ.

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Article Synopsis
  • Codonopsis pilosula and C. tangshen are two traditional Chinese medicinal plants, primarily known for their active polysaccharides, which were characterized in this study.
  • The study confirmed that the neutral polysaccharide fractions (CPPN and CTPN) are inulin-type fructans with different degrees of polymerization, affecting their biological activities.
  • Results showed that CPPN and CTPN enhance antioxidant defenses and promote the growth of beneficial Lactobacillus bacteria, indicating their potential as sources for intestinal health applications.
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In this study, two pectic polysaccharides from stems of Codonopsis pilosula (CPSP-1) and C. tangshen (CTSP-1) were obtained by ion exchange chromatography and gel filtration. The molecular weight of CPSP-1 and CTSP-1 were 13.

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New collections of six species from type localities in China were studied. The comparison of morphological characteristics and secondary metabolites with those of the type specimens and phylogenetic analyses suggest that and belong to , belongs to and should be retained in temporarily. Only two species, and , remain in .

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Two new species of the lichen genus are discovered in China, namely An. C. Yin & Li S.

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In this study, the diversity of Fr. in China was assessed based on morphological and chemical traits and molecular data are inferred from ITS and mtSSU sequences. Nineteen species were recognised, including three that are new to science (i.

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Background: Daily weight monitoring is frequently recommended as a part of heart failure self-management to prevent exacerbations. This study is to identify factors that influence weight monitoring compliance of congestive heart failure patients at baseline and after a 1-year weight management (WM) program.

Methods: This was a secondary analysis of an investigative study and a randomized controlled study.

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Aim: To elucidate the molecular and cellular features responsible for the increase of regulatory T cells (Tregs) in gastric cancer.

Methods: The frequencies of CD4(+)Foxp3(+) Tregs and the level of transforming growth factor-β1 (TGF-β1) were analyzed from 56 patients with gastric cancer by flow cytometry and enzyme-linked immunosorbent assay respectively. Foxp3 gene expression was analyzed by real-time polymerase chain reaction.

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Objective: To investigate if granulocyte-macrophage colony stimulating factor (GM-CSF) gene-modified dendritic cells (DC) enhance antitumor immunity in vitro.

Methods: Mice were injected with chemokine ligand 3 (CCL3) via the tail vein. Fresh B220(-)CD11c(+) cells were sorted from the peripheral blood mononuclear cells (PBMCs) and cultured into DCs by cytokines.

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Objective: To investigate the anti-gastric carcinoma immunological efficacy of dendritic cells (DC) precursors, that were mobilized into the peripheral blood by injection of macrophage inflammation protein-1 alpha (MIP-1 alpha), and induced by DC vaccine expressing melanoma antigen gene-3 (MAGE-3) ex vivo and in vivo.

Methods: 615 mice were injected with MIP-1 alpha via the tail vein. Freshly isolated B220(-) CD11c+ cells were cultured with cytokines and assayed by phenotype analysis and mixed lymphocyte reaction (MLR).

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To investigate whether tumor cell lysate-pulsed (TP) dendritic cells (DCs) induce cytotoxic T lymphocyte (CTL) activity against colon cancer in vitro and in vivo. Hematopoietic progenitor cells were magnetically isolated from BALB/c mice bone marrow cells. These cells were cultured with cytokines GM-CSF, IL-4, and TNFalpha to induce their maturation.

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Aim: To investigate whether bone marrow-derived denritic cells pulsed with tumor lysates induce immunity against gastric cancer ex vivo.

Methods: c-kit(+) hematopoietic progenitor cells were magnetically isolated with a MiniMACS separator from BALB/c mice bone marrow cells. These cells were cultured with cytokines GM-CSF, IL-4, and TNFalpha to induce their maturation.

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Article Synopsis
  • The study aimed to identify factors affecting mammosphere formation from different breast cancer cell lines (MCF-7, MDA-MB-231) and primary epithelial cells, as well as evaluate the presence of specific cancer stem cell markers (CD44+/CD24(-/low)).
  • MCF-7 cells had the highest ability to form mammospheres (2.1%), while MDA-MB-231 and primary cells showed little to no mammosphere formation. The proportion of CD44+/CD24(-/low) was significantly higher in MCF-7 mammosphere cells compared to its monolayer culture.
  • The research concluded that MCF-7 mammosphere cells have a
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Aim: To investigate the effect of a vaccine with recombinant adenovirus interleukin-12 (AdVIL-12) transduced dendritic cells (DCs) against colon cancer in mice.

Methods: DCs and AdVIL-12 were incubated together at different time intervals and at different doses. Supernatant was collected and tested for IL-12 by enzyme-linked immunosorbent assay (ELISA).

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Dendritic cells (DC) play a pivotal role in regulating immune responses. We previously reported aberrant high production of B lymphocyte chemoattractant (BLC/CXCL13) by DC in aged BWF1 mice, amurine model for systemic lupus erythematosus (SLE). We describe here that CD11b+CD11c+ cells were markedly increased in the peripheral blood (PBL-DC) in aged BWF1, but not in similarly aged NZB or NZW mice.

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