L- and T-type Ca channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma.

Retinal ganglion cell apoptotic death is the main pathological characteristic of glaucoma, which is the leading cause of irreversible blindness. Disruption of Ca homeostasis plays an important role in glaucoma. Voltage-gated Ca channel blockers have been shown to improve vision in patients with glaucoma.