Publications by authors named "Yan-Yan Ruan"

Article Synopsis
  • A two-stage genome-wide association study (GWAS) was conducted to identify susceptibility loci for schizophrenia in the Han Chinese population, involving a total of 5,675 individuals with schizophrenia and 7,202 healthy controls.
  • The study identified significant loci associated with schizophrenia at chromosome regions 6p21-p22.1 and 11p11.2, with multiple genetic markers showing strong statistical significance and varying odds ratios.
  • The findings suggest that genes NKAPL and ZKSCAN4, expressed in the developing mouse brain, could provide new insights into the underlying mechanisms of schizophrenia.
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Objective: To explore the treatment of cervical tracheoesophageal fistula (TEF) with complicated or remnant laryngotracheal stenosis (LTS) and anterior neck defect (AND).

Methods: From 1980 to 2007, 14 patients were diagnosed as TEF. Among them, 9 patients had complicated or remnant LTS, 3 patients had complicated AND, and 2 patients had TEF which were induced by Nickel-Titanium alloy mesh stent for treating benign esophageal stricture.

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Objective: To study the effect of anterior and posterior cricoid splitting interposition grafting for severe glottic and subglottic stenosis.

Methods: This is a retrospective study, from 1991 to 2001 years, 25 patients (male 15, female 10, aged 9 to 46 years) with severe glottic and subglottic stenosis were operated with anterior and posterior cricoid splitting interposition grafting method at Tangdu Hospital. All of 25 patients were tracheostomy dependent before reconstruction.

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In the past 8 years, 45 patients with laryngotracheal stenosis have undergone reconstruction with the sternohyoid myocutaneous rotary door flap (RDF) technique at Tang Du Teaching Hospital in Xi'an, China. All patients were tracheostomy-dependent before reconstruction. Thirty-six patients had previously undergone 2 to 7 surgical procedures.

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