Publications by authors named "Yan-Yan Bao"
To study the mechanism of polysaccharides from seeds of Vaccaria segetalis( PSV) in the treatment of bacterial cystitis through the NLRP3 inflammasome pathway. The rat model of urinary tract infection was used and treated with PSV,and the urine and bladders were collected. The level of interleukin-10( IL-10) in rat urine was detected by enzyme linked immunosorbent assay( ELISA).
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- A mouse model was created to study the effects of human coronavirus 229 E (HCoV-229 E) in traditional Chinese medicine, focusing on the syndrome of cold and dampness.
- The experiment included different groups receiving varying doses of Chaiyin Particles, which are used to treat symptoms associated with coronavirus pneumonia.
- Results showed that Chaiyin Particles significantly lowered lung disease severity and improved immune responses, indicating their potential as a treatment for the pneumonia modeled in this study.
The aim of this paper was to investigate the therapeutic effect of Compound Qinlan Oral Liquid recommended by Provincial Novel Coronary Virus Pneumonia Treatment Scheme on the treatment of BALB/c mice with combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome and to explore its clinical application in the treatment of novel coronavirus pneumonia, and to provide laboratory data support for clinical Chinese medicine. According to the classification of syndromes of novel coronavirus pneumonia by the national competent department of traditional Chinese medicine, this study determined that human coronavirus 229 E(HCoV-229 E)-infected mouse model of cold and dampness syndrome can be used to study human coronavirus pneumonia combined with pestilence attacking the lung syndrome model. This model is suitable for simulating traditional Chinese medicine treatment of common disease syndromes in Novel Coronavirus Pneumonia Diagnosis and Treatment program(trial implementation of the sixth edition).
View Article and Find Full Text PDF[Effect of Qingkailing injection on rat CYP1A2 and CYP2D6 activity].
Zhongguo Zhong Yao Za Zhi
October 2007
Objective: The present study investigates the influence of Qingkailing injection on rat liver CYP1A2 and CYP2D6 activity in vivo and in vitro, respectively.
Method: We employed HPLC to measure the metabolites of caffeine in the whole blood and calculated the ratio be between the metabolite and caffeine, which was used as index to evaluate the effect of Qingkailing injection on rat CYP1A2 activity in vivo; We also detected the CYP1A2 and CYP2D6 activity in microsomal reconstituted system by analysis of phenacetin metabolism and dextromethorphan metabolism with HPLC.
Result: The metabolism of caffeine in treated groups was (15.