Publications by authors named "Yan-Wen Zheng"

Article Synopsis
  • TM4SF1 is a protein that affects how brain cells grow and can help tumors like glioma, which is a really bad type of brain cancer in adults.
  • Researchers found that glioma tumors have a lot of TM4SF1, and when there is more TM4SF1, patients don’t live as long.
  • By shutting down TM4SF1, glioma cells grow slower and are less able to spread, which suggests TM4SF1 could be a good target for future treatments.
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Cholangiocarcinoma (CCA), which is highly malignant, shows a relatively poor prognosis, due to the insensitivity of the tumour to chemotherapy and radiotherapy. Photodynamic therapy (PDT) has become a promising palliative therapeutic option for patients with unresectable cholangiocarcinoma (CCA), while the functional amount of ROS is limited by intracellular redox systemen. Sulfasalazine (SASP), a well-known anti-inflammatory agent, which also acts as an inhibitor of the amino acid transport system xc (xCT), decreases the intracellular glutathione (GSH) level, thus weakening the antioxidant defence of the cell by inhibition of the antiporter.

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Liver malignancies include primary and metastatic tumors. Limited progress has been achieved in improving the survival rate of patients with advanced stage liver cancer and who are unsuitable for surgery. Apart from surgery, chemoradiotherapy, trans-arterial chemoembolization and radiofrequency ablation, a novel therapeutic modality is needed for the clinical treatment of liver cancer.

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Background: Emerging data suggest the crucial regulatory roles of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC). However, the pathophysiology role of circZFR in HCC remains largely unknown.

Aims: This study aims to disclose the functions of circZFR in HCC progression and its potential molecular mechanism.

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Background And Aims: The impact of portal hypertension (PH) on postoperative short-term outcomes and long-term survival in hepatocellular carcinoma (HCC) patients has lately been discussed controversially. This study aimed to explore the influence of PH on postoperative outcomes in HCC patients undergoing surgical resection.

Methods: Patients undergoing hepatectomy for HCC from 2010 to 2014 were enrolled.

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Aim: To determine the therapeutic effect of photodynamic therapy (PDT) for middle-advanced stage upper gastrointestinal carcinomas.

Methods: We searched PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database from inception to April 2018 for randomized controlled studies. These studies compared PDT with other palliative therapies (radiotherapy, chemotherapy, or Nd:YAG laser) and compared PDT, radiotherapy, or chemotherapy alone with PDT combined with chemotherapy/radiotherapy.

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Synopsis of recent research by authors named "Yan-Wen Zheng"

  • - Yan-Wen Zheng's research primarily focuses on the mechanisms and therapeutic strategies involving various cancers, particularly glioma, cholangiocarcinoma, and hepatocellular carcinoma, with an emphasis on targeting specific molecular pathways and enhancing treatment efficacy.
  • - Significant findings include the identification of TM4SF1 as a promoter of glioma malignancy and the role of sulfasalazine in sensitizing cholangiocarcinoma to photodynamic therapy by targeting the xCT amino acid transporter.
  • - Zheng's work also involves the investigation of the impact of circular RNAs and portal hypertension on cancer progression and postoperative outcomes, as well as a meta-analysis of photodynamic therapy for upper gastrointestinal carcinomas, showcasing the need for innovative therapeutic modalities in cancer treatment.