Publications by authors named "Yan-Shen Liu"
Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in a variety of pain models. Postherpetic neuralgia (Shingles) is a neuropathic pain conditioned with the presence of profound mechanical allodynia. Systemic injection of resiniferatoxin can reproduce the clinical symptoms of postherpetic neuralgia.
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- * In a model of postherpetic neuralgia (PHN), treatment with the TRPV1 agonist resiniferatoxin (RTX) led to increased levels of netrin-1 in spinal nerve cells, affecting associated receptors and promoting nerve fiber sprouting.
- * Targeting netrin-1 could be a potential strategy to alleviate mechanical allodynia and abnormal nerve growth in conditions like PHN by modifying the spinal environment in favor of nerve growth.