Exosome Transplantation From Patients With Schizophrenia Causes Schizophrenia-Relevant Behaviors in Mice: An Integrative Multi-omics Data Analysis.

Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but the role of exosomes in schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation of serum exosomes from SCZ patients into mice caused behavioral abnormalities such as deficits in prepulse inhibition and sociability, hyperactivity, and anxiogenesis. A comparative bioinformatics analysis suggested shared and distinct differentially expressed genes (DEGs) and enriched molecular pathways in the brains of SCZ exosome-recipient mice, methylazoxymethanol acetate-treated rats, and SCZ patients, which correlates evidence of altered prefrontal-hippocampal functional coherence in SCZ.

Coverage and parental perceptions of influenza vaccination among parents of children aged 6 to 23 months in Hong Kong.

Background: The impact of influenza on young children can be severe and even fatal. Influenza vaccination (IV) has been shown to be effective in reducing complications of influenza among children. This study investigated the prevalence and factors of IV among children aged 6-23 months in Hong Kong.

Knowledge of avian influenza (H5N1) among poultry workers, Hong Kong, China.

In 2009, a cross-sectional survey of 360 poultry workers in Hong Kong, China, showed that workers had inadequate levels of avian influenza (H5N1) risk knowledge, preventive behavior, and outbreak preparedness. The main barriers to preventive practices were low perceived benefits and interference with work. Poultry workers require occupation-specific health promotion.

[Study on the immunization coverage and effects of hepatitis B vaccine in the 20-59 years-old population in Guangzhou city].

Objective: To study the immunization coverage and immune effects of hepatitis B vaccine (HepB) among people who were immunized later than at birth in Guangzhou city.

Methods: A multistage randomized cluster sampling was used and the subjects were at age 20 to 59 years old, from the families of twelve districts in Guangzhou. Cross sectional analysis was carried out.

[The feasibility of outpatient data used for respiratory syndromic surveillance in general hospital].

Objective: To find out the data sources of respiratory syndromes and their components from the outpatients of general hospitals and to describe the time distribution and mutual relations of different respiratory syndromes. Feasibility of respiratory syndromes used for early warning surveillance on respiratory infectious disease was also under research.

Methods: Retrospective investigation on Hospital Information System (HIS) was implemented in a general hospital in Guangzhou, 2005, and data of outpatients was collected and classified into different syndromes.

[Needs on information related to influenza pandemic by the public].

Objective: To understand the information needs on human infection with avian influenza (H5N1), A (H1N1) and influenza pandemic in different time periods and create well-targeted messages by the public, so as to develop communication with the public effectively when human infection with avian influenza (H5N1), A (H1N1) and influenza pandemic occur.

Methods: Data were collected through questionnaire over telephone calls. The questionnaire was self-designed, revised after pilot testing.