Stachybotranes A-D, phenylspirodrimanes from the wetland fungus with cytotoxic activities.

Four new phenylspirodrimanes, stachybotranes A-D (-), along with seven known analogues (-), were isolated from the extract of a wetland fungal strain DTH12-9. The structures of new compounds were determined by spectroscopic analyses, X-ray crystallographic analysis, and the CD analysis of the in situ formed [Rh(OCOCF)] complex. Compounds -, -, and were evaluated for in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480.

Stachybisbins A and B, the first cases of seco-bisabosquals from Stachybotrys bisbyi.

Stachybisbins A (1) and B (2), two new meroterpenoids with unprecedented seco-bisabosqual skeleton, together with three biogenetically related metabolites (3-5), were isolated from a wetland fungal strain of Stachybotrys bisbyi. The structures of the new compounds were determined by spectroscopic analyses, modified Mosher's method, and quantum chemical CD method. The cytotoxic activities of all compounds were tested against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human cancer cell lines.

Three pairs of variecolortide enantiomers from Eurotium sp. with caspase-3 inhibitory activity.

7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1).