Publications by authors named "Yan-Qun Dong"
Objective: This study aimed to assess the efficacy and safety of sacral nerve root magnetic stimulation (SNRMS) combined with solifenacin in female patients with overactive bladder (OAB) symptoms.
Methods: A total of 183 female patients with OAB symptoms were prospectively randomized into 2 groups. Ninety-two patients in the combination group accepted SNRMS and solifenacin therapy and 91 patients serving as control accepted only solifenacin therapy.
Compound 5p is a 4β-N-substituted podophyllotoxin derivative, which exhibited potent activity toward drug-resistant K562/A02 cells and decreased MDR-1 mRNA expression. Here, we further investigated its detail mechanism and tested its antitumor activity. 5p exerted catalytic inhibition of topoisomerase IIα, and didn't show the inhibitor of topoisomerase I.
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- - IMB5476 is a newly identified nitrobenzoate microtubule inhibitor that shows better water solubility compared to its precursor, IMB5046.
- - It disrupts microtubule networks and halts the cell cycle at the G2/M phase, leading to cell death through mechanisms like mitotic catastrophe and apoptosis.
- - IMB5476 is effective against drug-resistant tumor cells, inhibits angiogenesis, and shows anti-tumor activity in mouse models, suggesting its potential as a treatment option that overcomes multidrug resistance.