Publications by authors named "Yan-Qiu Ou"
Article Synopsis
- A study was conducted to examine how regular internet usage affects overall and specific types of mortality among 21,481 older adults, aged around 64 years, over a span of 14 years.
- The findings revealed that regular internet users had a lower risk of dying from any cause (hazard ratio of 0.78) and particularly from cardiovascular diseases (hazard ratio of 0.72), with no significant differences based on age, sex, or lifestyle factors like exercise and alcohol consumption.
- The research also indicated that using the internet for about 2.1 to 4 hours daily may provide the greatest protective benefits against mortality, though more data is needed to fully confirm these trends.
Backgrounds: Short-term exposure to air pollutants increases the risk of migraine, but the long-term impacts of exposure to multiple pollutants on migraine have not been established. The aim of this large prospective cohort study was to explore these links.
Methods: A total of 458,664 participants who were free of migraine at baseline from the UK Biobank were studied.
Prenatal triclosan (TCS) exposure has been reported to be associated with various birth outcomes and thyroid function, while the study of TCS exposure for congenital heart disease (CHD) patients is limited. In the present study, paired mother-fetus blood samples from CHD and healthy participants were collected to measure TCS exposure levels, and then check their relationship. Coupled with the concentrations of thyroid function biomarkers [free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and thyroid antibodies (TgAb)] in maternal blood, we aimed to investigate whether the hormone-disrupting properties of TCS will affect its association with CHD.
View Article and Find Full Text PDFBackground: Previous studies have separately linked either perfluoroalkyl acid (PFAA) or heavy metal exposure with kidney dysfunction. However, the relationships of co-exposure to PFAAs and heavy metals with kidney function are still unclear.
Objectives: To explore the associations between exposure to PFAAs and heavy metals mixtures and kidney function in adults.
Experimental evidence has shown that per- and polyfluoroalkyl substances (PFAS) alternatives and mixtures may exert hepatotoxic effects in animals. However, epidemiological evidence is limited. This research aimed to explore associations of PFAS and the alternatives with liver function in a general adult population.
View Article and Find Full Text PDFBackground: Epidemiological studies on the associations of legacy per- and polyfluoroalkyl substances (PFASs) and glucose homeostasis remain discordant. Understanding of PFAS alternatives is limited, and few studies have reported joint associations of PFASs and PFAS alternatives.
Objectives: To investigate associations of novel PFAS alternatives (chlorinated perfluoroalkyl ether sulfonic acids, Cl-PFESAs and perfluorobutanoic acid, PFBA) and two legacy PFASs (Perfluorooctanoic acid, PFOA and perfluorooctane sulfonate, PFOS) with glucose-homeostasis markers and explore joint associations of 13 legacy and alternative PFASs with the selected outcomes.
Chlorinated polyfluoroalkyl ether sulfonates (Cl-PFESAs), are ubiquitous alternatives to perfluorooctane sulfonate (PFOS), a widely used poly- and perfluoroalkyl substance (PFAS). Despite in vivo and in vitro evidence of metabolic toxicity, no study has explored associations of Cl-PFESAs concentrations with metabolic syndrome (MetS) in a human population. To help address this data gap, we quantified 32 PFAS, including 2 PFOS alternative Cl-PFESAs (6:2 and 8:2 Cl-PFESAs) in serum from 1228 adults participating in the cross-sectional Isomers of C8 Health Project in China study.
View Article and Find Full Text PDF[Analysis of environmental risk factors in congenital heart defects].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2015
Objective: To explore the environmental risk factors of different categories of congenital heart defects (CHD) and provide evidence for further risk factors and prevention research of CHD phenotypes.
Methods: Data of Guangdong CHD Register Study from 2004 to 2012 were used. In the study, 3 038 CHD cases and 3 038 paired controls from 34 hospitals distributed in 17 cities were registered and related information were collected using uniform, and structured questionnaires.
Background: Neuroactive steroids represent promising candidates for the treatment of neurological disorders. Our previous studies identified an endogenous steroid cholestane-3β, 5α, 6β-triol (Triol) as a novel neuroprotectant.
Aim: We aimed to identify a potent candidate for stroke treatment through a screening of Triol analogs.
Article Synopsis
- The study compares risk factors for congenital heart defects (CHD) between floating populations (temporary migrants) and permanent residents in Guangdong over a period from 2004 to 2011.
- Researchers collected data on parents' health during pre-pregnancy and early pregnancy using the same questionnaire, resulting in 855 CHD cases from floating populations and 1,673 from permanent residents.
- Key findings show that maternal passive smoking and high family income are risk and protective factors, respectively, for the floating population, while for permanent residents, maternal diabetes and living in recently decorated homes pose risk factors; educational attainment had differing impacts on both groups.
[Risk factors of congenital heart defects in fetal and infants born from 2004 to 2011 in Guangdong].
Zhonghua Xin Xue Guan Bing Za Zhi
August 2013
Article Synopsis
- The study aimed to identify risk factors for congenital heart defects (CHD) in babies born in Guangdong province between 2004 and 2011, analyzing data from 2568 cases matched with a control group.
- Key findings revealed several high-risk factors for CHD, including low birth weight, exposure to chemicals during early pregnancy, abnormal reproductive history, and living near major traffic roads.
- The researchers concluded that effective intervention strategies should be implemented before and during early pregnancy to help lower the incidence of CHD among infants.
Article Synopsis
- - The study analyzed congenital heart disease (CHD) prevalence in infants under 12 months in Guangdong province, China, using data from 34 monitoring units to improve diagnostic accuracy through professional training.
- - Between 2004 and 2010, 383,281 perinatal cases were registered, revealing a total CHD prevalence rate of 0.851%, with higher rates in stillbirths compared to live births and a notable prevalence in the Pearl River Delta region.
- - The most common type of CHD identified was ventricular septal defect, followed by patent ductus arteriosus and secundum atrial septal defect, indicating a medium-upper prevalence level of CHD in Guangdong.
Aim: To investigate whether aspirin is able to augment gemcitabine-induced cytotoxicity in human pancreatic cancer cells.
Methods: Two gemcitabine-insensitive human pancreatic cancer cell lines, PANC-1 and Capan-1, were used. Cells were treated with either aspirin or gemcitabine alone or both of them.