Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model.

Aim: Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, has been shown to exert beneficial effects in heart failure. The purpose of this study was to test whether sildenafil suppressed transverse-tubule (T-tubule) remodeling in left ventricular (LV) failure and thereby providing the therapeutic benefits.

Methods: A pressure overload-induced murine heart failure model was established in mice by thoracic aortic banding (TAB).