Publications by authors named "Yan-Ping Bao"
Article Synopsis
- Antidepressants are widely prescribed but can lead to withdrawal symptoms upon discontinuation, with an overall incidence of 42.9% found in studies analyzed.
- The studies indicated that the incidence of withdrawal symptoms varies by type of antidepressant, with tricyclics showing the highest rates and a general trend of increased withdrawal symptoms with longer treatment durations.
- Strategies like tapering off medication can help reduce withdrawal symptoms, but several risk factors, including age and gender, influence the likelihood of experiencing these symptoms.
The concept of a healthy lifestyle is receiving increasing attention. This study sought to identify an optimal healthy lifestyle profile associated with sleep health in general population of China. An online cross-sectional survey was conducted from June to July 2022.
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- The study systematically reviews and analyzes the effectiveness and safety of psychedelics (psilocybin, ayahuasca, LSD, MDMA) in treating mental disorders based on 126 articles.
- Results indicate that psilocybin is the most researched and effective psychedelic for mood disorders, with the strongest therapeutic effects, followed by ayahuasca, MDMA, and LSD.
- While there are some risks, like headaches, most participants reported no lasting adverse effects, suggesting psychedelics may also help with various other mental health issues like addiction and PTSD.
Background: Painful physical symptoms (PPS) are highly prevalent in patients with major depressive disorder (MDD). Presence of PPS in depressed patients are potentially associated with poorer antidepressant treatment outcome. We aimed to evaluate the association of baseline pain levels and antidepressant treatment outcomes.
View Article and Find Full Text PDFPrevious studies have shown that excessive alcohol consumption is associated with poor sleep. However, the health risks of light-to-moderate alcohol consumption in relation to sleep traits (e.g.
View Article and Find Full Text PDFSecond-generation antipsychotics (SGAs) are widely used in treating schizophrenia and related disorders, also other mental disorders. However, the efficacy and safety of SGAs for treating other mental disorders is unclear. A systematic literature search for randomized, placebo-controlled trials of 11 SGAs for treating 18 mental disorders apart from schizophrenia were carried out from database inception to April 3, 2022.
View Article and Find Full Text PDFBackground: Responsiveness to opioid analgesics differs among patients with acute postoperative pain.
Objective: Our study presents the most recent evidence on the effect of genetic variations on postoperative pain, opioid consumption, nausea, and vomiting in patients treated with opioids.
Study Design: An updated systematic review and meta-analysis on the association between single-nucleotide polymorphisms and opioids administered to patients with acute postoperative pain.
Objective: This study aimed to explore both impairments in attention function in patients with major depressive disorder (MDD) and the efficacy of escitalopram monotherapy or combination therapy with agomelatine.
Methods: A total of 54 patients with MDD and 46 healthy controls (HCs) were included. Patients were treated with escitalopram for 12 weeks; those who presented with severe sleep impairments were also given agomelatine.
Article Synopsis
- * Results show no overall significant relationship between caffeine intake and amyloid positivity, but a notable inverse relationship was found in males, meaning caffeine may reduce the risk of amyloid presence for them.
- * No significant effect of caffeine was observed for females, and the research indicates further investigations are necessary to understand the underlying mechanisms of caffeine's influence on brain health.
[Challenges of and Responses to Mental Health Problems in the Post-COVID-19 Era].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2023
Since the first outbreak of the coronavirus disease 2019 (COVID-19), prevention and control of the pandemic remains a grim issue because of the continuous emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, and the constant emergence of new domestic outbreaks. During the COVID-19 pandemic, mental and psychological problems have increased significantly among different populations, including patients of COVID-19 and their families, health workers, college students, adolescents, children, and even the general population. At present, the COVID-19 epidemic situation in China is rather complicated.
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- Millions of pediatric COVID-19 survivors may experience long COVID symptoms after their acute illness, prompting a systematic review to assess prevalence and risk factors.
- The review analyzed 40 studies with over 12,000 individuals, revealing an overall long COVID prevalence of 23.36%, with the most common symptoms being generalized discomfort, respiratory issues, and fatigue.
- Key risk factors for long COVID included older age, multisystem inflammatory syndrome, and severe clinical symptoms, while individuals with poor mental or physical health were also at increased risk.
Article Synopsis
- * It identifies specific brain structures, especially the inferior orbitofrontal gyrus, that are linked to both depression and emotional recognition, indicating how changes in these regions might influence depressive symptoms.
- * The findings suggest that certain brain areas (like the frontal pole and precuneus) are more active in individuals with depression when faced with negative stimuli, highlighting the complex neurobiological mechanisms at play.
Insomnia is one of the most common and burdensome disorders in adults. We compared and ranked insomnia medication on the basis of their efficacy and tolerability. We performed a systematic review and network meta-analysis of placebo-controlled or head-to-head randomized controlled trials for primary insomnia in adults comparing 20 drugs.
View Article and Find Full Text PDFRepeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs. Previous studies suggested a role for adenosine monophosphate-activated protein kinase (AMPK), a cellular energy sensor, in modulating neuronal morphology and membrane excitability. However, the potential involvement of AMPK in cocaine use disorder is still unclear.
View Article and Find Full Text PDFObjectives: Sleep disturbances increase the risk of dementia; however, there is insufficient information regarding this. We aimed to investigate public knowledge on the relationship between sleep disturbances and dementia, as well as attitudes towards improving sleep quality and obtaining knowledge on dementia.
Design And Setting: A cross-sectional web-based questionnaire was administered between May and October 2019.
Aims: COVID-19 has long-term impacts on public mental health, while few research studies incorporate multidimensional methods to thoroughly characterise the psychological profile of general population and little detailed guidance exists for mental health management during the pandemic. This research aims to capture long-term psychological profile of general population following COVID-19 by integrating trajectory modelling approaches, latent trajectory pattern identification and network analyses.
Methods: Longitudinal data were collected from a nationwide sample of 18 804 adults in 12 months after COVID-19 outbreak in China.
Background: In the post-pandemic era, the emergence of sporadic cases of coronavirus disease 2019 (COVID-19) and the scale of the pandemic are unpredictable. Therefore, the impact of sporadic cases of COVID-19 and isolation measures on mental health and sleep in different groups of people need to be analyzed.
Aim: To clarify the severity of psychological problems and insomnia of staff and community residents around a hospital with sporadic cases of COVID-19, and their relationship with quarantine location and long-term changes.
The long-term physical and mental sequelae of COVID-19 are a growing public health concern, yet there is considerable uncertainty about their prevalence, persistence and predictors. We conducted a comprehensive, up-to-date meta-analysis of survivors' health consequences and sequelae for COVID-19. PubMed, Embase and the Cochrane Library were searched through Sep 30th, 2021.
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- * A systematic review identified 283 studies involving nearly 949,000 individuals, revealing that the prevalence of these mental health symptoms varied widely across different groups, with significant rates found in both survivors of infections and the general public.
- * Factors contributing to higher prevalence of mental health symptoms included being female and the progression of time during the COVID-19 pandemic, with mental health issues tending to rise for many while decreasing for infected patients.
Background: Vaccination is an important preventive measure against the coronavirus disease 19 (COVID-19) pandemic. We aimed to examine the willingness to vaccination and influencing factors among college students in China.
Methods: From March 18 to April 26, 2021, we conducted a cross-sectional online survey among college students from 30 universities in Wuhan, Hubei Province, China.