Publications by authors named "Yan-Pei Zou"
Article Synopsis
- The study discusses the challenges in creating bone-like scaffolds for regeneration due to the unique structure and composition of natural bone.
- Researchers developed a biomimetic scaffold made from decellularized extracellular matrix and regenerated silk fibroin, enhanced with magnetic nanoparticles, showing promising properties like good cytocompatibility and increased compressive strength.
- The scaffolds, when combined with an external magnetic field, promoted cell migration and bone formation, with underlying mechanisms related to the release of calcium, indicating potential for improved bone regeneration strategies.
Oxidative stress can lead to nucleus pulposus cell (NPC) apoptosis, which is considered to be one of the main contributors to intervertebral disc degeneration (IVDD). Procyanidin B2 is a natural antioxidant that protects against oxidative stress. However, whether procyanidin B2 protects NPCs from oxidative stress remains unknown.
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- The research investigates how scutellarin (SC), a natural compound, enhances exosome release from nucleus pulposus cells (NPCs) related to intervertebral disc degeneration (IDD).
- SC significantly increases autophagy levels in rat NPCs, which leads to more exosome release by affecting the PI3K/PTEN/Akt pathway.
- The study concludes that SC promotes exosome release by upregulating Rab8a through autophagy activation, suggesting potential new therapies for preventing IDD.
Objective: re is paucity in the literature on the epidemiological evidence of pulmonary thromboembolism (PE) and deep venous thrombosis (DVT) in spinal metastatic tumor patients. The aim of our study was to identify the incidence and risk factors for VTE in spinal metastasis patients treated with decompression with internal instruments.
Methods: We prospectively investigated the occurrence of VTE after decompression with internal fixations in 80 spinal metastasis patients.
Background: Exosomes may contain excess cellular components released by cells in response to harmful external stimuli to maintain cellular homeostasis. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), can induce cell apoptosis, alter cellular component expression levels, and stimulate exosome release. In this study, we examined whether exosomes released from nucleus pulposus cells (NPCs) under inflammatory conditions could induce normal NP cell apoptosis in rats and its underlining mechanism.
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