Publications by authors named "Yan-Nan Zang"
Population pharmacokinetics of olanzapine in pediatric patients with psychiatric disorders.
Expert Opin Drug Metab Toxicol
August 2024
Article Synopsis
- - The study aimed to create and validate a population pharmacokinetic model for oral olanzapine in pediatric Chinese patients to better tailor medication dosing for individuals aged 8-17 years.
- - Researchers collected data from 269 patients to analyze how various demographics and medications influence olanzapine levels, ultimately finding a one-compartment model that factors in body weight and sex for dosage calculations.
- - The developed model suggests specific doses for boys and girls based on weight and the presence of other medications, which could improve treatment efficacy for pediatric patients taking olanzapine.
Background: Danggui Longhui is a traditional Chinese medicine made from the dried root of Angelica sinensis. It is used in psychiatric patients in China to reduce associated constipation. In a population pharmacokinetic model in olanzapine patients from Beijing Anding Hospital, we demonstrate that dangguilonghui tablets doubled olanzapine clearance, indicating the induction of olanzapine metabolism.
View Article and Find Full Text PDFClozapine was first manufactured in China in 1976. Clozapine is currently used not only for treatment-refractory schizophrenia (TRS), but also continues to be used in the treatment of patients with non-TRS and other mental disorders; moreover, low-dose clozapine is also used in sedative-hypnotic therapy and in combination with other drugs. There is need for studies in China using various titrations and assessing their risk for myocarditis and aspiration pneumonia.
View Article and Find Full Text PDFBackground: This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance.
Methods: Thirteen published PPK models (labeled with letters A to M) not restricted to children were identified in PubMed, Embase, and Web of Science databases. They were evaluated in a sample totaling 411 serum concentrations from 146 adult inpatients diagnosed with bipolar disorder in a Chinese hospital.
Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder.
Eur J Clin Pharmacol
March 2022
Article Synopsis
- A population pharmacokinetic (PPK) model for valproic acid (VPA) was created to improve individualized treatment for adult Chinese patients with bipolar disorder.
- Data from 272 patients, including 1104 serum concentrations, was analyzed using nonlinear mixed-effects modeling, considering various demographic and biological factors.
- The final model indicated that VPA clearance is affected by sex, daily dosage, and body weight, offering a reliable method for personalizing VPA dosing in these patients.
Unlabelled: BACKGROUND AND OBJECTIVE: Prior olanzapine population pharmacokinetic (PPK) models have focused on the effects of sex and smoking on olanzapine clearance. This PPK model in Chinese adult psychiatric patients also investigated the influence of comedications and co-occurrence of infections on olanzapine clearance, and explored how to personalize oral olanzapine dosage in the clinical setting.
Methods: A total of 1546 serum concentrations from 354 patients were collected in this study.
Population pharmacokinetic study of delayed methotrexate excretion in children with acute lymphoblastic leukemia .
Int J Clin Pharmacol Ther
August 2019
Article Synopsis
- The study aimed to understand how methotrexate (MTX) is processed in children with acute lymphoblastic leukemia (ALL) by examining its delayed excretion patterns.
- Researchers analyzed 1,659 plasma samples from 190 patients, using specific software to assess various factors that might affect MTX levels, such as age and body size.
- The findings revealed a two-compartment model that accurately describes MTX clearance and distribution, indicating that body surface area significantly influences its clearance rate in these patients.
Purpose/background: In clozapine therapeutic drug monitoring (TDM) studies, Chinese reached the same concentrations using half the dosage Caucasians use. Defining clozapine poor metabolizers (PMs) requires stratification by ethnicity, smoking, and sex.
Methods/procedures: After sex and smoking stratification in 129 Chinese inpatients (mean, 8.
Article Synopsis
- The study aimed to analyze how the drug rE-4, a glucagon-like peptide-1 receptor agonist, is processed in the body of Chinese patients with type 2 diabetes to help tailor their treatment.
- Twelve patients received rE-4 injections and their dosage was adjusted based on glycated albumin levels, while data was analyzed using a two-compartment pharmacokinetic model.
- The findings revealed specific parameters related to the drug's absorption and distribution, highlighting significant variability among individuals but no external factors influenced these parameters significantly.
In single-molecule force spectroscopy, the unbinding force is often used to quantify the interaction strength of single molecular bonds. We analyze force spectroscopy of fast reversible bonds probed in thermodynamic equilibrium by considering the dynamics of force probe and molecular linker. The effect of cantilever and linker dynamics is systematically addressed by measuring the unbinding force of single cyclodextrin inclusion complexes by atomic force spectroscopy for a variety of molecular linkers and varying force probe stiffness.
View Article and Find Full Text PDFUse of a dose-response model to guide future clinical trial of benvitimod cream to treat mild and moderate psoriasis.
Int J Clin Pharmacol Ther
February 2016
Objective: To investigate the time-dose-response relationship of benvitimod cream after topical administration in patients with mild and moderate psoriasis vulgaris for dosage regimen exploring.
Methods: 36 patients with mild and moderate psoriasis vulgaris were randomly assigned to receive 0.5%, 1.