Publications by authors named "Yan-Na Gao"
Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation.
J Asian Nat Prod Res
October 2014
To study the anti-neuroinflammatory mechanisms of polygalasaponin F (PS-F), ELISA method was used to detect the secretion of inflammatory cytokines. Western blot was used to detect the protein expression and phosphorylation levels. Immunofluorescence assay was used to observe the NF-κB nuclear translocation.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is linked to the loss of dopamine-producing neurons and the presence of α-synuclein protein aggregates called Lewy bodies, with specific mutations (like E46K) contributing to familial PD.
- Recent research shows that the E46K mutation in α-synuclein negatively affects the autophagy process in cells, particularly at the early stages of forming autophagosomes.
- The impairment of autophagy caused by E46K mutant α-synuclein leads to increased cell vulnerability and may help explain its role in the progression of PD.