Publications by authors named "Yan-Ming Lei"

Batteries have become a ubiquitous daily necessity, which are popularly applied to mobile phones and electric vehicles according to their size. Improving the battery cycle life and storage is important, but unexpected discharge products still restrict the upper limit of batter performance such as LiO, LiO, and LiS. In this study, we calculated electrons and phonons presenting the basic energy states in crystal using the first-principles calculations.

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  • This study evaluates the combined effectiveness of transarterial chemoembolization (TACE) with PD-(L)1 inhibitors and molecular targeted treatments (MTT) compared to TACE alone in treating hepatocellular carcinoma (HCC).
  • It involved 826 patients, with 376 receiving the combination treatment and 450 undergoing TACE monotherapy, and measured outcomes like progression-free survival (PFS) and overall survival (OS).
  • Findings indicated that the combination treatment significantly improved PFS (9.5 months vs. 8.0 months) and OS (19.2 months vs. 15.7 months) while maintaining a manageable safety profile, especially in patients with advanced HCC.
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Forkhead box protein 3 (FOXP3) regulatory T cells (Tregs) are important in the maintenance of tumor immunity tolerance. Myeloid dendritic cells (mDCs) are antigen-presenting cells (APCs) specialized to initiate and regulate immunity. Tregs and mDCs are suspected of influencing the interaction between the tumor and immune system, and thus the course of tumors.

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  • - The study investigates the role of FOXP3(+) regulatory T cells (Tregs) and CD123(+) plasmacytoid dendritic cells (pDCs) in colorectal cancer (CRC), focusing on their infiltration in tumor and lymph node tissues, and how this relates to tumor immunity tolerance.
  • - Results show that FOXP3(+) Tregs are more abundant in CRC tumor tissues compared to normal tissue and are associated with more advanced cancer stages and lymph node metastasis.
  • - In contrast, CD123(+) pDCs are mostly lower in CRC tissues, but their levels are increased compared to adjacent normal tissue; the study indicates that pDCs may help promote Tregs development, particularly in metastatic
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NSCLC (non-small cell lung cancer) is the most common type of lung cancer and usually has poor prognosis. FOXP3 in regulatory T cells (Tregs) and toll-like receptor 4 (TLR4) on some tumor cells are known to be important for tumor escape and clinical tumor formation. Since FOXP3 was found recently in some tumor cells, we speculated if lung tumor cells express FOXP3 and then mimic Tregs to promote tumor escape.

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