Publications by authors named "Yan-Ling Yao"
Detection of gene mutation and its clinical significance in children with acute lymphoblastic leukemia.
Zhongguo Dang Dai Er Ke Za Zhi
March 2022
Article Synopsis
- The study aimed to analyze the mutation rate of specific genes in children with acute lymphoblastic leukemia (ALL) and assess its clinical relevance.
- Out of 120 children studied, 29.2% had a certain gene mutation, with a notable prevalence in B-lineage ALL cases, and these mutations were often located at the 12th and 13th codons.
- Children with gene mutations displayed significantly lower 2-year overall survival rates compared to those without, particularly when combined with overexpression and high white blood cell counts at diagnosis.
Adenovirus transfection technique was used in the current study to show if thioredoxin-interacting protein (TXNIP) overexpression can induce cell apoptosis and injury in H9C2 cardiomyocytes cultured in normal glucose condition. And the mechanisms were then investigated. Briefly, H9C2 cardiomyocytes in logarithmic growth phase were randomly divided into three groups: normal cultured group, empty adenovirus vector group (Ad-eGFP) and TXNIP overexpression group (Ad-TXNIP-eGFP).
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