Macrophages: Key players in diabetic wound healing.

In this editorial, we discuss the article by Wen published. Diabetic foot ulcers are prevalent and serious complications of diabetes, significantly impacting patients' quality of life and often leading to disability or death, thereby placing a heavy burden on society. Effective diabetic wound healing is hindered by an imbalance in macrophage polarization; many macrophages fail to transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which is crucial for tissue remodelling and repair.

Analysis of the efficacy and factors influencing survival of adjuvant radiotherapy for stage II-III biliary tract carcinoma.

Background: To determine the efficacy of adjuvant radiotherapy for stage II-III biliary tract carcinoma.

Methods: We retrospectively analyzed the data of 37 patients who underwent radical resection of biliary tract carcinomas at the Affiliated Hospital of Inner Mongolia Medical University between 2016 and 2020. We analyzed survival differences between patients who did (n = 17) and did not (n = 20) receive postoperative adjuvant radiotherapy by using Kaplan-Meier analysis.

Efficient Co-Adsorption and Highly Selective Separation of Cs and Sr with a K -Activated Niobium Germanate by the pH Control.

Cs and Sr are hazardous to ecological environment and human health due to their strong radioactivity, long half-life, and high mobility. However, effective adsorption and separation of Cs and Sr from acidic radioactive wastewater is challenging due to stability issues of material and the strong competition of protons. Herein, a K -activated niobium germanate (K-NGH-1) presents efficient Cs /Sr coadsorption and highly selective Cs /Sr separation, respectively, under different acidity conditions.

Association of mannose-binding lectin gene polymorphisms with the development of pulmonary tuberculosis in China.

Background: Mannose-binding lectin (MBL) is an important protein in the lectin pathway of the immune system. This study explores the association between MBL polymorphism and the susceptibility to tuberculosis (TB). The association between the MBL2 polymorphisms and serum MBL levels is also analyzed in the present study.

Application of hyperbranched rolling circle amplification for direct detection of mycobacterium tuberculosis in clinical sputum specimens.

Background: Global tuberculosis (TB) control is encumbered by the lack of a rapid and simple detection method for diagnosis, especially in low-resource areas. An isothermal amplification method, hyperbranched rolling circle amplification (HRCA), was optimized to detect Mycobacterium tuberculosis (Mtb) in clinical sputum specimens.

Methods: A clinical validation study was performed to assess the diagnostic accuracy of HRCA.

[Effects of nitrification inhibitors DCD and DMPP on cinnamon soil' s gross nitrogen mineralization and nitrification rates].

By using 15N pool dilution technique in combining with in situ soil cultivation, this paper studied the effects of nitrification inhibitors dicyandiamide (DCD) and 3,4-dimethylpyrazole phosphate (DMPP) on the gross nitrogen (N) mineralization and nitrification rates in a saline-alkali cinnamon soil in North China. The experiment was carried out in a maize-wheat rotation field in Yuncheng City of Shanxi Province, and three treatments were installed, i.e.

Bis[N'-(9H-fluoren-9-yl-idene)benzohydrazidato-κN',O]copper(II).

In the title complex, [Cu(C(20)H(13)N(2)O)(2)], the Cu(II) ion is tetra-coordinated by an N(2)O(2) set of two ligands in a distorted recta-ngular-planar geometry. The dihedral angle between the two coordinated five-membered metalla rings is 37.5 (3)°.

CREB is a positive transcriptional regulator of gamma interferon in latent but not active tuberculosis infections.

Gamma interferon (IFN-gamma) is a crucial cytokine for protection against Mycobacterium tuberculosis, but the mechanism of IFN-gamma transcription is still unclear. The cyclic AMP (cAMP) responsive element binding (CREB) proteins belong to the bZip (basic leucine zipper) family of transcription factors and are essential for T-cell function and cytokine production. This study focused on the capacity of CREB proteins to regulate IFN-gamma transcription in CD3(+) T cells obtained from tuberculosis (TB) patients and persons with latent tuberculosis infection (LTBI) in China.

μ(4)-Sulfido-bis-{(μ-2-furyl-methane-thiol-ato)bis-[tricarbonyl-iron](Fe-Fe)}.

The title compound, [Fe(4)(C(5)H(5)OS)(2)S(CO)(12)], was prepared by the direct reaction of Fe(3)(CO)(12) and 2-furyl-methane-thiol in tetra-hydro-furan. Desulfurization took place readily to form an Fe(4)S(3) cluster. The mol-ecule consists of two similar [(μ-2-C(4)H(3)O-CH(2)S)Fe(2)(CO)(6)] moieties joined to a spiro-type four-coordinate μ(4)-S atom such that this bridging sulfur is tetra-hedrally coordinated to the four Fe atoms.

[Role of siRNA mediated matrix metalloproteinase-2 gene silencing in the inhibition of invasion and growth of laryngeal cancer cells].

Objective: To explore the inhibitory effect of matrix metalloproteinase-2 (MMP-2) gene silencing in vitro and in vivo on the invasion and growth of laryngeal cancer cells.

Methods: siRNA recombinant lentivirus targeting MMP-2 gene was transfected into Hep-2 cells, and MMP-2 protein expression was analyzed consequently by using western-blot. Invasive properties of transfectants were evaluated by Boyden assay.

[The experimental investigation of the invasion and growth of laryngeal cancer by matrix metalloproteinase-2 and matrix metalloproteinase-9 gene silence together].

Objective: To investigate the inhibitive role of the invasion and growth of laryngeal cancer by lentivirus mediated Matrix Metalloproteinase-2 (MMP-2) and Matrix Metalloproteinase-2 (MMP-9) gene silence.

Methods: RNA interference (RNAi) technic was used. Recombinant lentivirus of small interference RNA targeting MMP-2 and MMP-9 gene were transduced into Hep-2 cells, and Reverse transcriptase polymerase chain reaction (RT-PCR) was used to test MMP-2 and MMP-9 expression in Hep-2 cells.

Synthesis and spectroscopic properties of rare earth picrate complexes with a new biphenylamide.

The new ligand N-benzyl-2-{2'-[(benzyl-ethyl-carbamoyl)-methoxy]-biphenyl-2-yloxy}-N-ethyl-acetamide (L) and its complexes of rare earth picrates were synthesized. The complexes were characterized by elemental analysis, IR, UV-vis spectra and conductivity measurements. The fluorescence properties of the europium complex in solid state and in CHCl(3), ethyl acetate, acetone, acetonitrile and DMF were investigated.

[The identification of Mycobacterium tuberculosis isolates by DNA typing technique].

Objective: To assess the application of IS6110-restriction fragment length polymorphism (RFLP), Spoligotyping and mycobacterial interspersed repetitive unit (MIRU) in epidemiological studies of tuberculosis and to discuss the characteristics of Mycobacterium tuberculosis strains in different regions in China.

Methods: Mycobacterium tuberculosis strains, with a total number of 158 isolates, were subjected to IS6110-RFLP, Spoligotyping and MIRU.

Results: The numbers of patterns produced by IS6110-RFLP, Spoligotyping, and MIRU typing were 118, 20 and 105 respectively.

Intrauterine infections and birth defects.

Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens' infections are described.