Publications by authors named "Yan-Lei Hao"
Objective To study the effects of TYRO protein kinase-binding protein (TYROBP) deficiency on learning behavior, glia activation and pro-inflammatory cycokines, and Tau phosphorylation of a new Alzheimer's disease (AD) mouse model carrying a p.G378E mutation.Methods A new AD mouse model carrying p.
View Article and Find Full Text PDFArticle Synopsis
- CEGI injection, made from rabbit muscle extract and cattle brain gangliosides, is used as a neuroprotectant for nerve injuries, but more clinical evidence is needed to support its efficacy.
- A study involving 319 patients with acute cerebral infarction in China scrutinized CEGI's effects in a randomized placebo-controlled trial over 14 days.
- Results indicated that patients receiving CEGI had better outcomes and reduced disabilities compared to the placebo group, with particularly significant improvements in those with moderate stroke.
Article Synopsis
- Researchers studied the effects of human umbilical cord-derived mesenchymal stromal cells (hWJ-MSCs) on aged male mice with sarcopenia caused by hindlimb suspension.
- The study found that mice receiving hWJ-MSCs showed significant improvements in muscle strength, endurance, and muscle mass, along with a decrease in cell death and inflammation.
- Results suggest that hWJ-MSCs could potentially help reduce sarcopenia by activating muscle stem cells and lowering inflammation in older adults.
Article Synopsis
- - The text discusses a case of a 48-year-old woman diagnosed with CPEO plus syndrome, which includes symptoms like limb weakness, ptosis, ophthalmoparesis, and cerebellar dysfunction, indicating a mitochondrial disorder.
- - She underwent various analyses and was treated with supplements such as CoQ10 and vitamin E, while her MRI showed global brain atrophy, and a muscle biopsy indicated ragged red fibers.
- - This case is significant as it's the first report documenting two rRNA mutations linked to CPEO plus, emphasizing the importance of early diagnosis and management to address related symptoms like cerebellar ataxia.
Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits.
View Article and Find Full Text PDFGuillain-Barré syndrome (GBS) is a post-infectious autoimmune disease. Dendritic cells (DCs) can recognize the pathogen and modulate the host immune response. Exploring the role of DCs in GBS will help our understanding of the disease development.
View Article and Find Full Text PDFToll-like receptor (TLR) 9, recognizing different ligands, confers distinct features of plasmacytoid dendritic cells (pDCs). Our previous study demonstrated a role for TLR9 in the mechanism of experimental autoimmune neuritis (EAN). In this study, we explored whether suppressive oligodeoxynucleotides (sODN) could induce tolerogenic pDCs via TLR9 and thus promote the recovery of EAN.
View Article and Find Full Text PDFBackground: Parkinson's disease (PD) is a common degenerative neurological disorder that causes loss of independence and decreased quality of life. The prevalence of PD tends to increase with age. In China, the morbidity rate of PD among people aged more than 65 years old is 1.
View Article and Find Full Text PDFBackground And Objective: Several studies assessed the efficacy of traditional Chinese medical exercise in the management of Parkinson's disease (PD), but its role remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the effect of traditional Chinese medical exercise for PD.
Methods: Seven English and Chinese electronic databases, up to October 2014, were searched to identify relevant studies.
Background: Recently, several studies assessed the effectiveness of Tai Chi for Parkinson's disease (PD), but the role of Tai Chi in the management of PD remained controversial. Therefore, the purpose of this systematic review is to evaluate the evidence on the efficacy of Tai Chi for PD.
Methods: Six English and Chinese electronic databases, up to April 2014, were searched to identify relevant studies.
MicroRNA-155 (miR155) has been demonstrated as a central regulator of immune responses induced by inflammatory mediators. Previous studies suggest that miR155 may play adverse effects in various diseases. We hereby explored the roles of miR155 in the pathogenesis of Guillain-Barré syndrome (GBS).
View Article and Find Full Text PDF