The role of non-coding RNA in the diagnosis and treatment of -related gastric cancer, with a focus on inflammation and immune response.

() is one of the globally recognized causative factors of gastric cancer (GC). Currently, no definite therapy and drugs for -related GC have been widely acknowledged although infection could be eradicated in early stage. Inflammation and immune response are spontaneous essential stages during infection.

Predicting Prognosis of Hepatocellular Carcinoma Patients Based on the Expression Signatures of Mitophagy Genes.

Background: The unbalance of mitophagy was closely related to hepatocellular carcinoma (HCC) progression. At present, it has not been uncovered about the influence of mitophagy genes on HCC prognosis and their potential pathogenesis.

Materials And Methods: The expression and clinical information of HCC in TCGA cohort were used to identify mitophagy differentially expressed genes (MDEGs) with prognostic value.

Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer.

Background: Single nucleotide polymorphisms (SNPs) are universally present in nucleotide excision repair (NER) pathway genes, which could make impacts on colorectal carcinogenesis and prognosis.

Aim: To explore the association of all tagSNPs in NER pathway genes with colorectal cancer (CRC) risk and prognosis in a northern Chinese population by a two-stage case-control design composed of a discovery and validation stage.

Methods: Genotyping for NER SNPs was performed using kompetitive allele specific PCR.

Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms.

It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness. However, the collective effects of SNPs have yet to be examined by experimental science. We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.

Synthesis, crystal structure and biological evaluation of a main group seven-coordinated bismuth(III) complex with 2-acetylpyridine N4-phenylthiosemicarbazone.

Up to now, bismuth(III) complexes with thiosemicarbazones have been comparatively rare. Here, a main group seven-coordinated bismuth(III) complex [Bi(L)(NO3)2(CH3CH2OH)] (1) (HL = 2-acetylpyridine N(4)-phenylthiosemicarbazone) has been synthesized and characterized by elemental analysis, IR, (1)H NMR and single-crystal X-ray diffraction studies. The cytotoxicity data suggest that 1 exhibits higher in vitro antiproliferative activity in four human cancer cells tested.

[Analysis of sucrose esters by thin-layer chromatography].

The thin-layer chromatographic method of sucrose esters was developed by the use of toluene-ethyl acetate-methanol-water (10:5:4.5:0.2 in volume ratio) as a mobile phase.