Constraints on the maintenance of wild populations based on regression conservation.

To clarify the key factors constraining the maintenance of wild populations and to develop conservation strategies and technical links for current populations, we investigated the renewal status and distribution patterns of wild populations in the main distribution areas of China. We analyzed the effects of stand factors and human disturbance on population renewal and maintenance. The results showed that the overall regeneration of wild populations was poor.

Evaluating Efficacy and Safety of Tacrolimus Treatment in Membranous Nephropathy: Results of a Retrospective Study of 182 Patients.

Purpose: Tacrolimus is recommended by KDIGO Clinical Practice Guidelines as an initial therapy for the treatment of membranous nephropathy (MN). However, little is known about the factors that influence response and recurrence of the disease after tacrolimus therapy, and there are limited data regarding the duration of tacrolimus treatment. Here, we present a real-world retrospective cohort study of 182 MN patients treated with tacrolimus, aiming to assess the efficacy and safety of tacrolimus in the treatment of MN.

The microstructures and mechanical properties of nanocrystalline LiSiO: molecular dynamics simulations.

The microstructures and mechanical properties of nanocrystalline LiSiO have been investigated molecular dynamics calculations. The results indicate that the mean atomic mass densities of nanostructured LiSiO with different mean grain size are slightly lower than that of ordinary crystal LiSiO. Interestingly, a significant anti-Hall-Petch effect between yield stress and average grain size is observed in the tensile deformation simulation of the samples.

[Chemotherapy resistance induced by interleukin-6 in ovarian cancer cells and its signal transduction pathways].

Objective: To study the mechanism of chemotherapy resistance caused by interleukin-6 (IL-6) in ovarian cancer cells and its related signal pathways.

Methods: Ovarian cancer cell lines A2780 (IL-6 receptor positive, while non-IL-6-expressing and cisplatin/paclitaxel-responsive) and SKOV3 cell lines (overexpressing of IL-6 receptor and IL-6 and cisplatin/paclitaxel-resistant) were suitable models for this study. The effect of exogenous (a short period of treatment with recombination IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) in A2780 cells or deleting of endogenous IL-6 expression in SKOV3 cells (by transfecting with plasmid encoding for antisense IL-6) on the sensitivity to cisplatin and paclitaxel was investigated.