Individualized vaginal applicator for stage IIb primary vaginal adenocarcinoma: A case report.

Background: Primary vaginal cancer is rare and most vaginal tumors are metastatic, often arising from adjacent gynecologic structures. Primary vaginal cancers are also more common among postmenopausal women and most of these are squamous cell carcinomas, with adenocarcinomas being relatively rare. Vaginal bleeding is the most common clinical manifestation of vaginal adenocarcinoma.

Modular supersonic nozzle for the stable laser-driven electron acceleration.

The sharp density down-ramp injection (shock injection) mechanism produces the quasi-monoenergetic electron beam with a bunch duration of tens of femtoseconds via laser wakefield acceleration. The stability of the accelerated electron beam strongly depends on the stability of the laser beam and the shock structure produced by the supersonic gas nozzle. In this paper, we report the study of a newly designed modular supersonic nozzle with a flexible stilling chamber and a converging-diverging structure.

Magnetic field amplification driven by the gyro motion of charged particles.

Spontaneous magnetic field generation plays important role in laser-plasma interactions. Strong quasi-static magnetic fields affect the thermal conductivity and the plasma dynamics, particularly in the case of ultra intense laser where the magnetic part of Lorentz force becomes as significant as the electric part. Kinetic simulations of giga-gauss magnetic field amplification via a laser irradiated microtube structure reveal the dynamics of charged particle implosions and the mechanism of magnetic field growth.

Dynamic mitigation of the tearing mode instability in a collisionless current sheet.

Dynamic mitigation for the tearing mode instability in the current sheet in collisionless plasmas is demonstrated by applying a wobbling electron current beam. The initial small amplitude modulations imposed on the current sheet induce the electric current filamentation and the reconnection of the magnetic field lines. When the wobbling or oscillatory motion is added from the electron beam having a form of a thin layer moving along the current sheet, the perturbation phase is mixed and consequently the instability growth is saturated remarkably, like in the case of the feed-forward control.

Intense, directional and tunable γ-ray emission via relativistic oscillating plasma mirror.

A mechanism for high energy γ-photon generation based on laser-plasma accelerator is proposed. The laser pulse with a peak intensity of 10W/cm accelerates the electron beam to GeV by the laser wakefield effect. A solid Aluminium target serves as a plasma mirror which is located at the rear side of a gas jet and reflects the laser pulse.

[MIG7 Regulates the Vasculogenic Mimicry Formation in Hepatocellular Carcinoma then Effects the Metastasis Potential of HCC].

Objectives: To investigate the expression of migration-inducing gene 7 (MIG7) in different HCC lines and its relationship with vasculogenic mimicry (VM) formation and metastatic potentiality.

Methods: Employing immunostaining to detect MIG7 protein expression and VM formation in 40 matched pairs of primary and metastatic HCC specimens from 40 patients, and investigating the correlation of VM formation with MIG7 protein expression. Detecting VM formation in HCC lines with different metastatic ability (MHCC-97H, MHCC-97L, Huh-7) and human normal hepatocyte line (L-02) through three-dimensional culture, and detecting mRNA expression with RT-PCR, investigating the correlation of MIG7 protein expression with VM formation and HCC metastatic potentiality with Western blot assay; screening the HCC cell line with high MIG7 expression.

Functional human TSHβ splice variant produced by plasma cell may be involved in the immunologic injury of thyroid in the patient with Hashimoto's thyroiditis.

Hashimoto's Thyroiditis (HT) is the most common cause of hypothyroidism in areas of the world where iodine levels are sufficient. However, the pathogenesis of HT has not been completely elucidated. The first functional human TSHβ splice variant was supposed to be involved in the pathology of Hashimoto's thyroiditis.

Laser ion acceleration toward future ion beam cancer therapy - Numerical simulation study -.

Background: Ion beam has been used in cancer treatment, and has a unique preferable feature to deposit its main energy inside a human body so that cancer cell could be killed by the ion beam. However, conventional ion accelerator tends to be huge in its size and its cost. In this paper a future intense-laser ion accelerator is proposed to make the ion accelerator compact.