Publications by authors named "Yan-Jia Shen"
Article Synopsis
- The study investigates how quercetin, a natural compound, protects the blood-brain barrier (BBB) in rats after a stroke induced by middle cerebral artery occlusion and subsequent reperfusion.
- Administering quercetin at various doses resulted in a significant reduction in brain damage, neurological deficits, and BBB permeability while also lowering reactive oxygen species (ROS) levels.
- The protective effects of quercetin were linked to the Sirt1/Nrf2/HO-1 signaling pathway, and the use of a Sirt1 inhibitor reversed these benefits, highlighting the importance of this pathway in neuroprotection.
[Network pharmacology study of Xiaoxuming Decoction based on vasodilatory and vasoconstrictory related GPCR targets].
Zhongguo Zhong Yao Za Zhi
December 2018
In this study, bioinformatics methods such as molecular docking and network pharmacology were adopted to establish Xiaoxuming Decoction (XXMD) "compound-vasodilatory and vasoconstrictory related G protein-coupled receptors (GPCR) targets" network, then the vascular function regulatory effective components and the potential targets of XXMD were analyzed. Based on the XXMD herb sources, the chemical structures of the compounds were retrieved from the national scientific data sharing platform for population and health pharmaceutical information center, TCMSP database and the latest research literatures. The chemical molecular library was established after class prediction and screening for medicinal and metabolic properties.
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