Publications by authors named "Yan-Hu Wu"
Article Synopsis
- Atrial fibrillation (AF) is a common heart rhythm disorder, and this study investigates the role of transcription factors NF-AT3 and NF-AT4 in atrial structural changes associated with AF and their relationship with collagen biomarkers.
- Right and left atrial samples from 90 patients undergoing valve replacement surgery were analyzed, measuring the expression of NF-AT3, NF-AT4, and collagen types I and III, alongside serum levels of specific collagen-related markers.
- The findings indicate that NF-AT3 and NF-AT4 are elevated in AF patients, particularly in the left atrium, suggesting they are involved in the structural remodeling of the heart, and highlighting PICP and TGF-β1 as potential serum biomarkers for
Background: Functional tricuspid regurgitation often occurs in patients with concomitant left sided, valve disease. Several types of tricuspid valve annuloplasty have been described, but there is no consensus on the management of functional tricuspid regurgitation. We report a modified annuloplasty technique and compare its efficacy with the conventional Kay technique.
View Article and Find Full Text PDFAims: The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of different types of patients with atrial fibrillation (AF) associated with valvular heart disease (VHD).
Methods And Results: Right atrial specimens obtained from 65 patients undergoing valve replacement surgery were divided into three groups: sinus rhythm group (n= 24), paroxysmal atrial fibrillation group (PaAF; n= 10), and persistent atrial fibrillation group (PeAF; AF lasting >6 month; n= 31). The expression levels of mRNA and protein content for CIB1, calcineurin B, calcineurin A, and Na(+)-Ca(2+) exchanger-1 (NCX1) were measured.