Publications by authors named "Yan-Hong Wang"

Evidence mapping was performed to review the clinical trials and systematic reviews about the treatment of hyperlipidemia with Chinese patent medicines in recent ten years. A total of 387 clinical studies and 18 systematic reviews/Meta-analysis involving 45 Chinese patent medicines commonly used in the treatment of hyperlipidemia in recent ten years were retrieved from Chinese and English academic publication databases. The article information was extracted by reading the abstract and full text, and the evidence of publication trend, combined medication, intervention course, complications, and outcome indicators was sorted out.

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5-(3',4'-Dihydroxyphenyl)-γ-valerolactone (VL) is a bioactive metabolite resulting from the gut microbial metabolism of proanthocyanidins and flavonoids, known for its health-promoting effects, including antidiabetic and anti-inflammatory activities. Although VL has been observed in different in vivo studies, its pre-absorption, distribution, metabolism, excretion, toxicity (ADMET) properties have rarely been investigated. This study aims to address this gap by evaluating the pre-ADMET properties of VL for the first time.

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Objective: To investigate the clinical characteristics of patients with hemophagocytic lymphohistiocytosis (HLH) and quantify the diagnostic value of various indexes in patients with elevated soluble interleukin-2 receptor (sCD25), so as to construct a diagnostic prediction model of HLH.

Methods: The clinical characteristics of 121 patients with elevated sCD25 (≥2 400 U/ml) in the Third Affiliated Hospital of Sun Yat-Sen University were analyzed retrospectively. The patients were divided into HLH group and non-HLH group according to the diagnostic criteria of HLH.

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Article Synopsis
  • Bacterial lysates, like OM-85, help boost the immune system and could prevent infections, especially in the lungs.
  • OM-85 is made from 21 different strains of common bacteria and can help with various health issues like asthma and lung cancer.
  • Studies suggest that using OM-85 might improve treatments for these illnesses and can be especially helpful for children and pregnant women.
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Background: In this study, we aimed to develop a method for the simultaneous quantification of methotrexate (MTX) samples extracted from human plasma and cerebrospinal fluid (CSF), using two-dimensional liquid chromatography (2D-LC). Furthermore, we intended to verify whether intravenous mannitol could increase MTX concentration in the CSF of patients.

Methods: The mobile phase of PUMP1 consisted of 10.

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Imrecoxib, a cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug (NSAID), was discovered via the balanced inhibition strategy of COX-1/COX-2. It is indicated for the relief of painful symptoms of osteoarthritis. There have been some pharmacological and therapeutic advances since the approval of imrecoxib in 2011.

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  • Nine compounds were extracted from ethanolic extracts, including one new alkaloid and one new pentacyclic triterpenoid, plus seven known alkaloids.
  • The structures of the new compounds were determined using 1D and 2D NMR spectroscopy and high-resolution mass spectrometry.
  • The antiproliferative activity of the compounds was tested against two cancer cell lines (LN229, A549), but compounds did not show significant activity.
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  • The study analyzed the diagnostic and prognostic significance of Kruppel-like factor 5 (KLF5) and Runt-related transcription factor 1 (RUNX1) in patients with sepsis-induced acute kidney injury (SI-AKI) by measuring their levels in blood samples from 120 patients divided into SI-AKI and non-AKI groups.
  • Results indicated that both KLF5 and RUNX1 levels were significantly elevated in SI-AKI patients, proving their effectiveness in distinguishing these patients from those without kidney injury.
  • Furthermore, high levels of KLF5 and RUNX1 were linked to poor 28-day survival outcomes in SI-AKI patients, establishing their potential as independent prognostic markers for survival.*
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Phytochemical investigation of the roots of (Turcz.) Schischk resulted in the isolation of twelve coumarin derivatives including one new 3,4-dihydroisocoumarin () and eleven known 3,4-unsubstituted coumarins (). Structural elucidation of compounds was established by 1D and 2D NMR spectra referring to the literature, together with high-resolution mass spectrometric analysis.

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Background: Skeletal muscle relaxants (SMRs) are widely used in treating musculoskeletal conditions. All SMRs, with the exception of baclofen and tizanidine, are on the list of 2023 American Geriatrics Society Beers Criteria for potentially inappropriate medication use in older adults. In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics.

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  • * The paper emphasizes the important role clinical nurses can play in MR by checking and educating patients about their medications, but they need proper training and motivation to do so.
  • * Collaborative efforts among healthcare professionals can help resolve medication discrepancies and prevent harm to older patients, highlighting the need for further research on the cost-effectiveness and educational aspects of MR in nursing.
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Nine polyacetylenes, including five new compounds named sadivaethynes E-I (1-5), were isolated from the roots of Saposhnikovia divaricata. Structural elucidation of compounds 1-5 was established by extensive spectroscopic analysis, quantum chemical calculations and DP4 probability analysis. Among them, the absolute configuration of compound 1-2, 4-5 was unambiguous determined by ECD.

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  • Genomic DNA of porcine circovirus 4 (PCV4) has been found in pigs in various regions of China and South Korea, but its prevalence in Gansu Province, China was previously unknown.
  • Research conducted from 2022 to 2023 collected 121 clinical pig samples from Gansu, identifying 13 positive for PCV4, resulting in a 10.74% positivity rate.
  • The study also sequenced and analyzed two distinct PCV4 strains, showing high genetic similarity to existing reference strains and marking the first comprehensive report on PCV4 in Gansu, highlighting the need for effective control strategies against this virus.
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Background: Phlebitis is a common complication of intravenous administration and greatly affects clinical outcomes, patient satisfaction, and health-care expenditure. Numerous studies have revealed venous injuries only through visual and histopathological examination. Although sporadic studies have explored the cellular and molecular biological mechanisms of phlebitis and the outcomes of pharmacological interventions, an updated review over the last decade is not available.

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Lavender ( Miller or Chaix) is an ethnopharmacological plant commonly known as English lavender. Linalool and linalyl acetate are putative phytoactives in lavender essential oil (LEO) derived from the flower heads. LEO has been used in aroma or massage therapy to reduce sleep disturbance and to mitigate anxiety.

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Identifying novel phytochemical secondary metabolites following classical pharmacognostic investigations is tedious and often involves repetitive chromatographic efforts. During the past decade, Ultra-High Performance Liquid Chromatography-Quadrupole Time of Flight-Tandem Mass Spectrometry (UHPLC-QToF-MS/MS), in combination with molecular networking, has been successfully demonstrated for the rapid dereplication of novel natural products in complex mixtures. As a logical application of such innovative tools in botanical research, more than 40 unique 3-oxy-, 3, 6-dioxy-, and 3, 6, 27-trioxy-steroidal saponins were identified in aerial parts and rhizomes of botanically verified .

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Pomegranate extracts standardized to punicalagins are a rich source of ellagitannins including ellagic acid (EA). Recent evidence suggests that gut microbiota-derived urolithin (Uro) metabolites of ellagitannins are pharmacologically active. Studies have evaluated the pharmacokinetics of EA, however, little is known about the disposition of urolithin metabolites (urolithin A (UA) and B (UB)).

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Article Synopsis
  • - The French Lentil & Leek Crumbles have been recalled due to gastrointestinal problems, with 393 complaints and 133 hospitalizations linked to the product.
  • - Researchers suspect that tara protein flour, a key ingredient, may be responsible for these health issues, particularly focusing on a compound called ()-(-)-baikiain found in tara.
  • - Tests on ND4 mice revealed that baikiain significantly elevated blood ALT levels and decreased liver GSH, indicating potential liver damage.
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Objective: Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuropathology and cognitive decline and associated with age. The comprehensive deoxyribonucleic acid methylation (DNAm)-transcriptome profile association analysis conducted in this study aimed to establish whole-genome DNAm profiles and explore DNAm-related genes and their potential functions. More appropriate biomarkers were expected to be identified in terms of AD.

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Background: New drugs are urgently needed for the treatment of liver cancer, a feat that could be feasibly accomplished by finding new therapeutic purposes for marketed drugs to save time and costs. As a new class of national anti-infective drugs, carrimycin (CAM) has strong activity against gram-positive bacteria and no cross resistance with similar drugs. Studies have shown that the components of CAM have anticancer effects.

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The development and application of botanical insecticides is important for the sustainable development of green agriculture. The abuse of chemical pesticides has caused serious problems of environment and human health. Botanical insecticides have become an environment-friendly insecticides due to their nature, low toxicity, easy degradation and other advantages, which are an important field of insecticide development in the future.

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