Publications by authors named "Yan-Hong Shan"
Article Synopsis
- - The study developed a human immune system (HIS) mouse model to better understand human materno-fetal immunity, which is crucial for clearing pathogens while tolerating the fetus.
- - Human immunity shows a tolerant state mid-gestation (E14.5) but becomes inflammatory by late gestation (E19), with macrophages and Treg cells playing critical roles in this immune transition.
- - This HIS mouse model can enhance our knowledge of human materno-fetal immunity and could aid in drug discovery for reproductive disorders.
Background: SARS-CoV-2 infection in pregnant women during the third trimester resulted in overall adverse pregnancy outcomes compared to non-infected controls and a unique humoral and cellular response at delivery. In this study we aimed to assess the impact of SARS-CoV-2 infection on maternal/neonatal peripartum outcomes andimmunological profiles.
Method: In this study, we recruited 304 SARS-CoV-2 infected pregnant women and 910 SARS-CoV-2 non-infected pregnant women who were admitted for delivery.
[Pro-apoptotic effects of curcumin associated with CIK cells against ovarian carcinoma cells].
Zhonghua Yi Xue Za Zhi
January 2013
Objective: To observe the pro-apoptotic effects of Curcumin associated with CIK cells against SKOV3 cells of ovarian carcinoma and discusses the possible molecular mechanisms.
Methods: CIK cells were induced from umbilicus cord blood. The apoptotic morphology of SKOV3 cells was observed under electron microscope after treated with Cur, CIK cells and Cur associated with CIK cells.
Heparin affects both dermal fibroblast proliferation and collagen and may mediate these effects by altering the levels of basic fibroblast growth factor (bFGF) and transforming growth factor-beta1 (TGF-beta1) production as a wound healing modulator. The purpose of this study is to probe the effect of heparin on bFGF and TGF-beta1 production by human normal skin and hyperplastic scar fibroblasts. This research investigates the effect of heparin on bFGF and TGF-beta1 production by human normal skin and hyperplastic scar fibroblasts with exposure to 0, 100, 300, or 600 microg/ml heparin for 24, 48, 72, or 96 hours in a serum-free in vitro model.
View Article and Find Full Text PDF[Study on poly A site gene mutation of transforming growth factor-beta1 receptor type II between multiple and single site keloid].
Zhonghua Zheng Xing Wai Ke Za Zhi
January 2006
Article Synopsis
- - The study aimed to explore the differences in the development of multiple and single site keloids by analyzing mutations in the Poly A site of the TbetaR II gene.
- - Researchers collected 20 keloid samples (6 from multiple sites and 14 from single sites), extracted DNA, and used PCR and sequencing techniques to identify mutations.
- - Results showed that the mutation rate at the Poly A site was significantly higher in multiple site keloids (50%) compared to single site keloids (7.1%), suggesting differing underlying mechanisms for the two types.