Publications by authors named "Yan-Hong Qu"
Mutation in the tumor suppressor gene p53 is the most frequent molecular defect in endometrial carcinoma (EC). Recently, CP-31398, a p53-stabilizing compound, has been indicated to possess the ability to alter the expression of non-p53 target genes in addition to p53 downstream genes in tumor cells. Herein, we explore the alternative mechanisms underlying the restoration of EC tumor suppressor function in mutant p53 by CP-31398.
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- Tyrosine hydroxylase (TH) is crucial for dopamine production in neurons, and there's emerging evidence that traumatic brain injury (TBI) disrupts dopamine neurotransmission.
- Researchers studied the effects of controlled cortical impact (CCI) injury on TH levels in rats at different recovery times (1, 7, and 28 days).
- Results showed that TH protein levels increased bilaterally in the nigrostriatal system of injured rats at 28 days, suggesting a compensatory response in dopaminergic neurons to enhance dopamine synthesis after TBI.
Disturbances in dopamine neurotransmission contribute to frontal lobe dysfunction after traumatic brain injury. The changes in dopamine neurotransmission may be mediated by alterations in the dopamine transporter, which plays a key role in maintaining dopamine homeostasis. To determine whether the dopamine transporter system is altered after traumatic brain injury, dopamine transporter protein was examined bilaterally in the rat frontal cortex by Western blot at 1, 7, and 28 days after controlled cortical impact or sham injury ( = 6/group).
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