Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.

Background: The long noncoding RNAs (lncRNAs) have been confirmed to be involved in sepsis-induced organ injury. Here, we first investigated the functional role and the underlying mechanism of lncRNA LINC00472 in sepsis-induced acute hepatic injury (AHI).

Methods: Human liver THLE-3 cells were treated with lipopolysaccharide (LPS) to mimic sepsis-induced AHI in vitro; intraperitoneal injection of LPS in rats were used as an in vivo model of AHI induced by sepsis.

[Alterations of peripheral blood T cell subsets in patients with sepsis and the clinical implications].

Objective: To observe the dynamic changes of CD3+, CD4+, and CD8+ T lymphocytes in the peripheral blood of patients with sepsis and discuss the clinical significance.

Methods: Sixty-four patients admitted in the Emergency Center and Emergency Intensive Care Unit of the Second Hospital of Wenzhou Medical University between August, 2007 and July, 2009 were enrolled in this study. CD3+, CD4+, and CD8+ T lymphocytes in the peripheral blood were detected by flow cytometry on days 1, 7 and 14 after admission, and the results were compared between the patients with improvement of the condition and those without improvement, with 20 healthy subjects as the control group.

[Seasonal variations of calorific values of Pinus koraiensis-broadleaved mixed forest litters and soil macrofauna in China temperate zone].

In this paper, the calorific values of Pinus koraiensis-broadleaved mixed forest litters and soil microfauna in China temperate zone were determined, with their seasonal variation patterns studied. The results showed that both the calorific values and their seasonal variation patterns were differed with the kinds of tree species litters and soil macrofauna in the mixed forest. The mean gross calorific value (GCV) of P.