Publications by authors named "Yan-Hong Piao"
Objectives: Dopamine receptor D2 gene (DRD2) and glucocorticoid receptor gene (NR3C1) are implicated in the development of psychosis. We investigated methylation levels of DRD2 and NR3C1 in peripheral blood of patients with recent-onset (RO) psychosis using bisulfite pyrosequencing as well as its association with childhood trauma and rumination.
Methods: In all, 51 individuals with RO psychosis and 47 healthy controls were recruited.
Methylome-wide Association Study of Patients with Recent-onset Psychosis.
Clin Psychopharmacol Neurosci
August 2022
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls.
Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis.
Article Synopsis
- The study focuses on creating the Korea Polyenvironmental Risk Score (K-PERS) to understand risk factors for developing psychosis, specifically targeting the differentiation between patients with schizophrenia spectrum disorders (SSDs) and healthy individuals (HCs).
- Existing measurement tools were reviewed to construct K-PERS, which includes two versions: K-PERS-I (five factors) and K-PERS-II (six factors); both effectively distinguished between SSD and HC groups.
- Results indicated a significant correlation between K-PERS scores and negative symptoms of psychosis, highlighting the tool's potential for further research into clinical outcomes related to schizophrenia.
Article Synopsis
- The study aimed to explore the demographic, clinical features, cognitive functions, and 1-year outcomes of patients with psychotic disorder not otherwise specified (PNOS) compared to those with early-stage schizophrenia (SZ).
- Researchers assessed 54 PNOS patients and 321 SZ patients, with follow-ups revealing differences in symptom severity, treatment response, and compliance.
- Results showed that PNOS patients had better diagnostic stability, symptom severity, and treatment response but lower compliance, indicating that PNOS may be a distinct clinical condition requiring unique treatment strategies.
Childhood trauma (ChT) is a risk factor for psychosis. Negative lifestyle factors such as rumination, negative schemas, and poor diet and exercise are common in psychosis. The present study aimed to perform a network analysis of interactions between ChT and negative lifestyle in patients and controls.
View Article and Find Full Text PDFAim: In the present study, the prevalence and predictors of symptomatic and full remission were investigated in patients with first-episode psychosis (FEP) at the 12-month follow-up.
Methods: A total of 308 participants aged 18-45 years fulfilled the study inclusion criteria and 214 completed the 12-month follow-up.
Results: At the 12-month follow-up, 67.
Background: Network approach has been applied to a wide variety of psychiatric disorders. The aim of the present study was to identify network structures of remitters and non-remitters in patients with first-episode psychosis (FEP) at baseline and the 6-month follow-up.
Methods: Participants ( = 252) from the Korean Early Psychosis Study (KEPS) were enrolled.
Stathmin (), a microtubule-destabilizing factor, can regulate fear, anxiety, and learning. Social defeat stress (SDS) has detrimental effects on mental health and increases the risk of various psychiatric diseases. This study investigated the effects of gene knockout (KO) on behavioral parameters and dopaminergic markers using an SDS mouse model.
View Article and Find Full Text PDFObjective: Social defeat represents a naturalistic form of conditioned fear and is often used as an animal model of depression. The present study aimed to identify the neurochemicals in select brain regions of mice exposed to social defeat stress.
Methods: Adult C57BL/6N mice were subjected social defeat stress for 10 days.