Publications by authors named "Yan-Fen Cui"
Article Synopsis
- The study analyzed whether MRI-based radiomics features can effectively predict good response (GR) to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC).
- Researchers extracted radiomics features from imaging of 1,070 LARC patients and developed models to enhance prediction accuracy, incorporating both radiomic and key clinical MRI features into a combined model.
- The combined model demonstrated strong predictive capabilities for GR, leading to better disease-free survival outcomes for patients identified as high likelihood for GR, and was validated across multiple datasets with a high-quality score.
Background: This study aimed to explore the incidence of occult lymph node metastasis (OLM) in clinical TNM (cTNM) small cell lung cancer (SCLC) patients and develop machine learning prediction models using preoperative intratumoral and peritumoral contrast-enhanced CT-based radiomic data.
Methods: By conducting a retrospective analysis involving 242 eligible patients from 4 centeres, we determined the incidence of OLM in cTNM SCLC patients. For each lesion, two ROIs were defined using the gross tumour volume (GTV) and peritumoral volume 15 mm around the tumour (PTV).
CXCR7/CXCL12 axis is involved in lymph node and liver metastasis of gastric carcinoma.
World J Gastroenterol
May 2017
Aim: To investigate the role of CXC chemokine receptor (CXCR)-7 and CXCL12 in lymph node and liver metastasis of gastric carcinoma.
Methods: In 160 cases of gastric cancer, the expression of CXCR7 and CXCL12 in tumor and matched tumor-adjacent non-cancer tissues, in the lymph nodes around the stomach and in the liver was detected using immunohistochemistry to analyze the relationship between CXCR7/CXCL12 expression and clinicopathological features and to determine whether CXCR7 and CXCL12 constitute a biological axis to promote lymph node and liver metastasis of gastric cancer. Furthermore, the CXCR7 gene was silenced and overexpressed in human gastric cancer SGC-7901 cells, and cell proliferation, migration and invasiveness were measured by the MTT, wound healing and Transwell assays, respectively.
Aim: To evaluate the feasibility of low contrast medium and radiation dose for hepatic computed tomography (CT) perfusion of rabbit VX2 tumor.
Methods: Eleven rabbits with hepatic VX2 tumor underwent perfusion CT scanning with a 24-h interval between a conventional tube potential (120 kVp) protocol with 350 mgI/mL contrast medium and filtered back projection, and a low tube potential (80 kVp) protocol with 270 mgI/mL contrast medium with iterative reconstruction. Correlation and agreement among perfusion parameters acquired by the conventional and low dose protocols were assessed for the viable tumor component as well as whole tumor.
[Preparation and application of anti-serum against mouse Foxp3].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
February 2008
Aim: To prepare the high titer and specific anti-serum against mouse Foxp3 and then use them to identify Foxp3 expression in normal mouse tissues.
Methods: The Foxp3 fragment was amplified by polymerase chain reactions(PCR) and cloned into the prokaryotic expression vector pGEX-6p-2. The recombinant plasmid pGEX-6p-2/Foxp3 was transformed into E.