Publications by authors named "Yan-Fei Yu"
Article Synopsis
- A new multi-classifier system combines lncRNA, deep learning from whole slide images, and clinicopathological data to improve predictions of recurrence in localized papillary renal cell carcinoma (pRCC) after surgery.
- *The system shows significantly better predictive accuracy for recurrence-free survival (RFS) than using any single classifier alone, with C-index values ranging from 0.831 to 0.858.
- *This method helps identify high-risk patients more accurately, allowing for individualized treatment strategies alongside the current cancer staging system.
Article Synopsis
- A novel assay was developed to predict recurrence in patients with localised renal cell carcinoma after surgery, integrating clinical, genomic, and histopathological data.
- A deep learning-based histopathological score was combined with scores from genetic and clinical factors to create a more accurate multimodal recurrence score.
- This new score showed significantly better predictive accuracy for recurrence-free intervals (RFI) compared to traditional methods, especially identifying high-risk patients, demonstrating its potential for improving patient management post-surgery.
Accumulating evidence indicates that the alternative splicing program undergoes extensive changes during cancer development and progression. The RNA-binding protein QKI-5 is frequently downregulated and exhibits anti-tumor activity in lung cancer. Howeve-r, little is known about the functional targets and regulatory mechanism of QKI-5.
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