Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China: focus on the safety.

Background: World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis (DR-TB) should develop and implement a system for active pharmacovigilance that allows for detection, reporting and management of adverse events. The aim of the study is to evaluate the frequency and severity of adverse events (AEs) of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant (MDR)/extensively drug-resistant (XDR)-TB based on active drug safety monitoring (aDSM) system of New Drug Introduction and Protection Program (NDIP).

Methods: AEs were prospectively collected with demographic, bacteriological, radiological and clinical data from 54 sites throughout China at patient enrollment and during treatment between February, 2018 and December, 2019.

[Effects of ZnO Nanoparticles, ZnSO₄ and Arbuscular Mycorrhizal Fungus on the Growth of Maize].

As one of the most widely used metal-based nanoparticles (NPs), ZnO NPs have been shown to be toxic to organisms. Arbuscular mycorrhizal (AM) fungi can improve mineral nutrition and increase the resistance of host plants. However, little is known on the interaction between ZnO NPs and other Zn pollutants, as well as the effect of AM fungi on their biological effects.

[Characteristics of ammonium N and nitrate N accumulation in dryland soil in relation with wheat yield].

A total of eleven field trials in Yongshou, Shaanxi Province and seven in Luoyang, Henan Province were conducted with two treatments (without N as control and with 150 kg N x hm(-2) addition). The wheat biomass and seed yield were determined, and so were the nitrate and ammonium N concentrations in five layers (0-20, 20-40, 40-60, 60-80, 80-100 cm) at each trial site. Results showed that soil ammonium concentrations in the two provinces were very low while nitrate N concentrations were relatively high.

[Contribution of wheat rhizosphere respiration to soil respiration under elevated atmospheric CO2 and nitrogen application].

With the support of free-air carbon dioxide enrichment (FACE) system and by using isotope 13C technique, and through planting wheat (Triticum aestivum L., C3 crop) on a soil having been planted with maize (Zea mays L., C4 crop) for many years, this paper studied the effects of elevated atmospheric CO2 and nitrogen application on the delta 13C value of soil emitted CO2 and the wheat rhizosphere respiration.

[Molecular typing of isolates from two dysentery outbreaks in Chengdu, through pulsed field gel electrophoresis technology].

Objective: Using pulsed field gel electrophoresis (PFGE) and polymerase chain reaction (PCR) typing to analyze strains isolated from two outbreaks caused by Shigella sonnei and to trace the source of infection.

Methods: Virulence genes ipaH and ial were detected by PCR and PFGE was used to subtype the isolates. Patterns were compared, using the software BioNumerics.