Circ-POLA2-mediated miR-138-5p/SEMA4C axis affects colon cancer cell activities.

This study aimed to investigate the mechanism of circ-POLA2 in colon cancer (CC). Circ-POLA2, miR-138-5p, and SEMA4C levels in CC tissues and cells were recorded. The influences mediated by circ-POLA2, miR-138-5p or SEMA4C on cell proliferation, migration, invasion, and apoptosis were determined.

Induced dipoles incorporated into all-atom Zn protein simulations with multiscale modeling.

Zinc is found saturated in the deposited Amyloid-beta (Aβ) peptide plaques in Alzheimer's disease (AD) patients' brains. Binding of zinc promotes aggregation of Aβ, including the pathogenic aggregates. Up to now, only the region 1-16 of Aβ complexed with zinc (Aβ(1-16)-Zn) is defined structurally in experiment.