Amine-Imine Nickel Catalysts with Pendant O-Donor Groups for Ethylene (Co)Polymerization.

The introduction of a secondary interaction is an efficient strategy to modulate transition-metal-catalyzed ethylene (co)polymerization. In this contribution, O-donor groups were suspended on amine-imine ligands to synthesize a series of nickel complexes. By adjusting the interaction between the nickel metal center and the O-donor group on the ligands, these nickel complexes exhibited high activities for ethylene polymerization (up to 3.

The Novel Function of Unsymmetrical Chiral CCN Pincer Nickel Complexes as Chemotherapeutic Agents Targeting Prostate Cancer Cells.

We report that the pincer nickel complexes display prostate cancer antitumor properties through inhibition of cell proliferation. Notably, they display better antitumor properties than cisplatin. Mechanistic studies reveal that these pincer nickel complexes trigger cell apoptosis, most likely due to cell cycle arrest.

The effect of poly(lactic-co-glycolic acid) conduit loading insulin-like growth factor 1 modified by a collagen-binding domain on peripheral nerve injury in rats.

Peripheral nerve injury (PNI) exists widely and seriously affects patients' daily lives. However, the effect of nerve repair is still limited, and only 50% of patients can recover useful functions. To overcome these obstacles, collagen-coated poly(lactic-co-glycolic acid) (PLGA) conduits loaded with CBD-IGF-1 were designed and tested in vitro and in vivo.

Unusual -Kaurane Diterpenes from the Cultivar S288 Coffee Beans and Molecular Docking to α-Glucosidase.

A total of 11 new (-) and 2 known ( and ) -kaurane diterpene derivatives were identified from the roasted beans of cultivar S288. Their structures were established by extensive spectroscopic analysis, including one- and two-dimensional nuclear magnetic resonance (heteronuclear single-quantum correlation, heteronuclear multiple-bond correlation, correlation spectroscopy, and rotating-frame Overhauser enhancement spectroscopy), high-resolution electrospray ionization mass spectrometry, and X-ray analyses. Cafespirone acid A () represents the first example of diterpene featuring a spirocyclic skeleton constructed from a 6/6/5 tricyclic system.

First case of forearm crisscross injury in children: A case report.

Background: Forearm crisscross injury is rare in children; there is no relevant literature so far. Surgeons lack experience and knowledge in treating this type of crisscross injury. We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.

Quantitative serum HBV markers in predicting phases of natural history of chronic HBV infection.

Background: Clinical importance of commercially available quantitative HBV markers has not been fully investigated.

Objective: To choice and to evaluate clinically valuable HBV markers for predicting phases of natural history with chronic HBV infection.

Methods: 472 naïve patients with chronic HBV infection were enrolled, in which 21 and 220 were confirmed as HBeAg-positive inactive and active hepatitis (EPIH and EPAH), respectively, and 106 and 125 were confirmed as HBeAg-negative inactive and active hepatitis (ENIH and ENAH), respectively.

Separation, identification, and molecular docking of tyrosinase inhibitory peptides from the hydrolysates of defatted walnut (Juglans regia L.) meal.

Defatted walnut meal protein was hydrolyzed using alcalase to yield tyrosinase inhibitory peptides. After separation by ultrafiltration and Sephadex G-25, the fraction with the highest tyrosinase inhibitory activity was identified using liquid chromatography-tandem mass spectrometry and 606 peptides were obtained. Then, molecular docking was used to screen for tyrosinase inhibitory peptides and to clarify the theoretical interaction mechanism between the peptides and tyrosinase.

NaOH-Mediated Direct Synthesis of Quinoxalines from -Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy.

A NaOH-mediated sustainable synthesis of functionalized quinoxalines is disclosed via redox condensation of -nitroamines with diols and α-hydroxy ketones. Under optimized conditions, various -nitroamines and alcohols are well tolerated to generate the desired products in 44-99% yields without transition metals and external redox additives.

Performance of Hepatitis B Core-Related Antigen Versus Hepatitis B Surface Antigen and Hepatitis B Virus DNA in Predicting HBeAg-positive and HBeAg-negative Chronic Hepatitis.

Background: We examined changes in hepatitis B core-related antigen (HBcrAg) during the four sequential phases of chronic hepatitis B virus (HBV) infection: hepatitis B e antigen (HBeAg)-positive chronic infection (EPCI) and hepatitis (EPCH), followed by HBeAg-negative chronic infection (ENCI) and hepatitis (ENCH). We compared the performance of serum HBcrAg, hepatitis B surface antigen (HBsAg), and HBV DNA in predicting EPCH and ENCH.

Methods: We enrolled 492 consecutive patients: 49 with EPCI, 243 with EPCH, 101 with ENCI, and 99 with ENCH.

Hydration of the methanesulfonate-ammonia/amine complex and its atmospheric implications.

Methanesulfonate (MSA), found in substantial concentrations in the atmosphere, is expected to enhance aerosol nucleation and the growth of nanoparticles, but the details of methanesulfonate clusters are poorly understood. In this study, MSA was chosen along with ammonia (NH) or three common amines and water (HO) to discuss the roles of ternary homogeneous nucleation and ion-induced nucleation in aerosol formation. We studied the structural characteristics and thermodynamics of the clusters using density functional theory at the PW91PW91/6-311++G(3df,3pd) level.

Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B.

Background: The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) hold promise for further optimization of therapy. Here, we aimed to characterize HBcrAg during the natural course of CHB.

Network analysis identifies common genes associated with obesity in six obesity-related diseases.

Obesity has been reported to be associated with many diseases. However, common obesity-induced biological processes have not been evaluated across these diseases. We identified genes associated with obesity and obesity-related diseases, and used them to construct protein‒protein interaction networks.

Measurement of the hepatitis B core-related antigen is valuable for predicting the pathological status of liver tissues in chronic hepatitis B patients.

The objective of this study was to evaluate the validities of serum hepatitis B core-related antigen (HBcrAg) for predicting the pathological status of liver tissues of chronic hepatitis B (CHB). A total of 205 Chinese patients with CHB, including 121 HBeAg-positive and 84 HBeAg-negative patients, were enrolled in this study. In HBeAg-positive patients, AUCs of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis were greater than 0.

Significantly reduced adsorption and activation of blood components in a membrane oxygenator system coated with crosslinkable zwitterionic copolymer.

Unlabelled: A crosslinkable zwitterionic copolymer PMBT was coated onto the surfaces of polypropylene hollow fiber membrane (PP-HFM) oxygenator and its connecting tubes. The PMBT copolymer coating on the oxygenator circuit formed a cell outer membrane mimetic surface with excellent stability. The hemocompatibility of the PMBT copolymer coated PP-HFM oxygenator circuit was evaluated by animal extracorporeal circulation.

Substrate independent coating formation and anti-biofouling performance improvement of mussel inspired polydopamine.

Mussel inspired polydopamine (PDA) coating has been proven to be a simple and effective method for surface modification of biomaterials. However, the adhesive functional groups remaining on the surface of PDA coating may promote the attachment of nonspecific proteins and microorganisms and hinder anti-biofouling performance. In this study, the PDA coating formation process is monitored in real-time by a sensitive surface plasmon resonance (SPR) technique at different pH values, initial dopamine concentrations and deposition times.

Biocompatible and antifouling coating of cell membrane phosphorylcholine and mussel catechol modified multi-arm PEGs.

The design and easy fabrication of biocompatible and antifouling coatings on different materials are extremely important for biotechnological and biomedical devices. Here we report a substrate-independent biomimetic modification strategy for fabricating a biocompatible and antifouling ultra-thin coating. Cell membrane antifouling phosphorylcholine (PC) and/or mussel adhesive catechol (c) groups are grafted at the amino-ends of an 8-armed poly(ethylene glycol).

Parent and halogenated polycyclic aromatic hydrocarbons in farmed cockroaches and implications for human exposure.

Medicinal insects have been widely used to cure human diseases for ages. Nevertheless, knowledge about the toxic chemicals accumulated in medicinal insects and their effects on human health was insufficient. In the present study, sixteen priority polycyclic aromatic hydrocarbons (PAHs) and nine halogenated PAHs (HPAHs) were determined in farmed medicinal cockroaches to address this issue.

[A novel pol SAR image classification method with subsequent category adjustment by terrain scattering characteristic].

The present paper,on the basis of analyzing the terrain scattering characteristics, proposed a novel supervised classification method combined with complex Wishart classifier ideology. This method used coherent matrix which almost contains all the polarization information to make subsequent adjustments for the supervised classification result to achieve higher accuracy division categories. For the first beginning, supervised classification was carried out on the Cloude & Pottier polarimetric characteristics combination to get the initial classification result.

[The impact of load density differences on land subsidence based on build-up index and PS-InSAR technology].

The excessive mining for underground water is the main reason inducing the land subsidence in Beijing, while, increasing of load brought by the urban construction aggravate the local land subsidence in a certain degree. As an international metropolis, the problems of land subsidence that caused by urban construction are becoming increasingly highlights, so revealing the relationship between regional load increase and the response of land subsidence also becomes one of the key problems in the land subsidence research field. In order to analyze the relationship between the load changes in construction and the land subsidence quantitatively, the present study selected the TM remote sensing image covering Beijing plain and used Erdas Modeler tool to invert the index based on building site (IBI), acquired the spatial and temporal change information in research area further; Based on results monitored by PS-InSAR (permanent scatterer interferometry) and IBI index method, and combined with the GIS spatial analysis method in the view of pixels in different scales, this paper analyzes the correlation between typical area load change and land subsidence, The conclusions show that there is a positive correlation between the density of load and the homogeneity of subsidence, especially in area which has a high sedimentation rate.

Surface reconstruction and hemocompatibility improvement of a phosphorylcholine end-capped poly(butylene succinate) coating.

Control over cell-material surface interactions is the key to many new and improved biomedical devices. In this study, we present a simple yet effective surface modification method that allows for the surface reconstruction and formation of cell outer membrane mimetic structure on coatings that have significantly increased hemocompatibility. To achieve this, a phosphorylcholine end-capped poly(butylene succinate) (PBS-PC) was synthesized and dip-coated on coverslips.

Fine root branch orders contribute differentially to uptake, allocation, and return of potentially toxic metals.

Growing evidence has revealed high heterogeneity of fine root networks in both structure and function, with different root orders corporately maintaining trees' physiological activities. However, little information is available on how fine root heterogeneity of trees responds to environmental stresses. We examined concentrations of seven potentially toxic metals (Cr, Ni, Cu, Zn, As, Cd, and Pb) within fine root networks and their correlations with root morphological and macro-elemental traits in six Chinese subtropical trees.

Fabrication and hemocompatibility of cell outer membrane mimetic surfaces on chitosan by layer by layer assembly with polyanion bearing phosphorylcholine groups.

Three random copolymers poly(2-methacryloyloxyethyl phosphorylcholine-co-methacrylic acid) (PMAs) were synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid (MA) with different monomer ratios under monomer-starved conditions. The synthesized PMA polyanions were assembled on chitosan (CS) film surfaces via electrostatic interactions. Using layer by layer (LbL) assembly with PMA polyanion and chitosan polycation, PMA/CS multilayer thin films with phosphorylcholine groups on the outer surfaces were fabricated.

[Enhancing the induced immune responses of Lagurus lagurus zona pellucida 3 DNA vaccine by molecular adjuvant C3d].

To investigate the enhancement of Lagurus lagurus zona pellucida 3 gene (lzp3) immunization induced by molecular adjuvant C3d in comparison with plasmid pcDNA3-LZP3 (pcD-L) in non-C3d fused form, the eukaryotic expression vector pcDNA3-LZP3-C3d3 (pcD-LC) including lzp3 and three copies of C3d in fusion form was constructed. In vitro,RT-PCR and Western blot showed that lzp3 mRNA and protein were expressed in HeLa cells transfected with pcD-L and pcD-LC, respectively. In vivo,the result of ELISA showed that NIH female mice vaccined with pcD-LC elicited higher titer, longer lasting anti-LZP3 antibody than non-C3d fused form pcD-L (P<0.