Publications by authors named "Yan-Bing Cui"
To reveal the genetic characteristics of one member of the Plasmodium falciparum repetitive interspersed family (rif), we sequenced the rif gene (PF3D7_1254800) in 53 field isolates collected from Ghana-imported cases into China and compared them with 350 publicly available P. falciparum rif sequences from global populations. In the Ghana-imported population, the nucleotide diversities were 0.
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- Imported malaria cases are a concern in malaria-free countries due to high transmission rates in neighboring regions, emphasizing the need for a genetic database for monitoring.
- The study analyzed 10 whole-genome isolates from inland China’s recent malaria outbreaks (2011-2012) to understand genomic epidemiology during the pre-elimination stage.
- Results showed that inland malaria populations were genetically distinct with evidence of drug resistance and positive selection in key gene families, indicating fragmentation and low relatedness among infections despite multiclonal infections.
Article Synopsis
- The study focuses on the apical membrane antigen-1 (PvAMA-1), a critical target for developing a malaria vaccine for vivax malaria, highlighting its genetic variation as a key challenge.
- Researchers analyzed the genetic diversity of the PvAMA-1 gene from 152 malaria isolates collected from the China-Myanmar border between 2009-2016 and compared these to 73 samples from Myanmar, revealing significant polymorphism.
- Findings indicate that the PvAMA-1 gene displays high genetic diversity and positive selection, particularly in domain I, which may impact the effectiveness of future PvAMA-1-based malaria vaccines.
Malaria incidence has declined dramatically over the past decade and China was certified malaria-free in 2021. However, the presence of malaria in border areas and the importation of cases of malaria parasites are major challenges for the consolidation of the achievements made by China. Duffy binding protein (PvDBP) performs a significant role in erythrocyte invasion, and is considered a promising vaccine.
View Article and Find Full Text PDFGenome-Wide Scans for Ghanaian Genes Under Selection From Local and Chinese Host Populations.
Front Cell Infect Microbiol
July 2021
Initial malarial infection mostly causes symptomatic illness in humans. Infection that is not fatal induces complete protection from severe illness and death, and thus complete protection from severe illness or death is granted with sufficient exposure. However, malaria parasite immunity necessitates constant exposure.
View Article and Find Full Text PDF: (Pv) and account together for a considerable share of the global burden of malaria, along with (Pf). However, inaccurate diagnosis and undetectable asymptomatic/submicroscopic malaria infections remain very challenging. Blood-stage antigens involved in either invasion of red blood cells or sequestration/cytoadherence of parasitized erythrocytes have been immunomics-characterized, and are vital for the detection of malaria incidence.
View Article and Find Full Text PDFBackground: China has made progress in malaria control and aims to eliminate malaria nationwide, but implementing effective interventions along the border regions remain a huge task. The Plasmodium falciparum cases imported from Southeast Asia has frequently reported especially in the China-Myanmar border (CMB) area. Though, information is scant on P.
View Article and Find Full Text PDF[Genotypes of hepatitis B virus in Henan Luohe area].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
August 2008
Objective: To determine the main genotype of hepatitis B virus (HBV) prevailed in Henan Luohe area.
Methods: Serum specimens were collected from 94 HBsAg positive individuals, and HBV S gene were obtained by PCR amplifying, and the gene sequences were analyzed and the polygenetic tree was drawn by the software MEGA3.
Results: About 75.