Publications by authors named "Yan-An-Lan Chen"
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and its prognosis remains poor. Although growing numbers of studies have verified the involvement of circular RNAs (circRNAs) in various cancer types, their specific functions in ICC remain elusive. Herein, a circRNA, circUGP2 is identified by circRNA sequencing, which is downregulated in ICC tissues and correlated with patients' prognosis.
View Article and Find Full Text PDFApolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway.
Cell Mol Gastroenterol Hepatol
March 2024
Background & Aims: Apolipoprotein A-1 (ApoA-1), the main apolipoprotein of high-density lipoprotein, has been well studied in the area of lipid metabolism and cardiovascular diseases. In this project, we clarify the function and mechanism of ApoA-1 in liver regeneration.
Methods: Seventy percent of partial hepatectomy was applied in male ApoA-1 knockout mice and wild-type mice to investigate the effects of ApoA-1 on liver regeneration.
Article Synopsis
- ApoA-1, a key protein in high-density lipoprotein, plays a significant role in reducing liver damage and inflammation during hepatic ischemia-reperfusion injury, but its mechanisms were previously unclear.
- In experiments on mice, lack of ApoA-1 led to worse liver damage and an increased inflammatory response, particularly noting a rise in a type of cell death called pyroptosis in macrophages.
- The study concludes that ApoA-1 protects against liver injury by reducing pyroptosis through the TLR4-NF-κB signaling pathway, suggesting potential therapeutic options for managing hepatic ischemia-reperfusion injury.