Publications by authors named "Yan Z Mach"

Article Synopsis
  • Histone acetylation and deacetylation are key processes that regulate gene expression during cellular differentiation and tissue development.
  • The p300 coactivator is crucial for activating myogenic factors like Myf5 and MyoD, which are necessary for muscle development.
  • HDACs, particularly HDAC11, are involved in gene repression and may influence the transition of stem cells to myoblasts, highlighting their importance in early muscle differentiation.
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Dynamic changes in epigenetic landscape reflect a critical command of lineage-specific gene expression. In an effort to discern the epigenetic regulatory networks of myogenic differentiation, we have used systematic and integrative approaches to explore multi-omics datasets on global myogenic gene expression, histone acetylation and acetyltransferase occupancy in view of distinct chromatin states. In this brief report, we discuss experimental design and provide a comprehensive assessment regarding data quality control, filtering and processing.

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