Innovative public strategies in response to COVID-19: A review of practices from China.

The COVID-19 pandemic presented unparalleled challenges to prompt and adaptive responses from nations worldwide. This review examines China's multifaceted approach to the crisis, focusing on five key areas of response: infrastructure and system design, medical care and treatment, disease prevention and control, economic and social resilience, and China's engagement in global health. This review demonstrates the effectiveness of a top-down command system at the national level, intersectoral coordination, a legal framework, and public social governance.

Longitudinal Efficacy of Nusinersen Treatment on Health-Related Quality of Life and Independence in Children With Later-Onset Spinal Muscular Atrophy.

Introduction/aims: The rising use of disease-modifying therapy is progressively impacting the health-related quality of life (HRQoL) of patients with spinal muscular atrophy (SMA) in their daily lives. This study aimed to evaluate the changes in HRQoL and independence in children with later-onset SMA receiving longitudinal treatment with nusinersen.

Methods: Forty-nine pediatric patients with later-onset SMA (symptom onset after 6 months of age) and their caregivers were enrolled.

One Neglected Complication in the BPA Process? Severe Vagal Response During the Angioplasty Procedure-A Case Report.

Balloon pulmonary angioplasty (BPA) is now a widely accepted treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but it still faces the problem of high complications. Herein, we report a rare case of severe vagal response during the BPA of a total occlusion lesion in a patient with CTEPH. The patient experienced acute chest pain and dyspnea, accompanied by a significant decrease in heart rate and blood pressure.

Oligodendrocyte Progenitor Cell Transplantation Reduces White Matter Injury in a Fetal Goat Model.

Background: Preterm white matter injury (PWMI) is the most common type of brain injury in preterm infants, in which, oligodendrocyte progenitor cells (OPCs) are predominantly damaged. In this study, human OPCs (hOPCs) were administered to a fetal goat model of PWMI to examine the differentiation potential and therapeutic effects of the cells on PWMI.

Methods: Preterm goat fetuses were subjected to hypoxic-ischemia (HI) via intermittent umbilical cord occlusion (5 min × 5).

Lung squamous cell carcinoma with metastases in the left atrium and left ventricle responds to treatment with immunotherapy: A case report.

Tumor metastasis is a phenomenon in which tumor cells grow in distant organs far from their primary site and is the final and most lethal manifestation of cancer. Most patients with cancer succumb to metastatic disease, not primary tumors. The occurrence of cardiac metastases is rare, but any primary tumor can potentially metastasize to the heart.

Preclinical Evaluation of an AlF-Radiolabeled Bicyclic Peptide Targeting Nectin-4.

Precisely assessing nectin-4 expression in tumors is important in identifying patients who may benefit from nectin-4-targeted therapies. In our previous work, we developed a bicyclic peptide-based nectin-4-targeting radiotracer Ga-N188 and validated its nectin-4 detection efficacy. However, the relatively short half-life and low positron emission rate of Ga limit its further application.

Decoding β-catenin associated protein-protein interactions: Emerging cancer therapeutic opportunities.

The hyperactive Wnt/β-catenin signaling circuit has been proven to be closely related to the progression of various cancers, with β-catenin serving as a central regulator of pro-tumorigenic processes. Preclinical evidences strongly support β-catenin as a promising therapeutic target. However, it has long been considered "undruggable" due to challenges such as the lack of crystal structures for its N- and C-terminal domains, high mutation rates, and limited availability of inhibitors.

Lysosome-Mitochondria Cascade Targeting Nanoparticle Drives Robust Pyroptosis for Cancer Immunotherapy.

The subcellular distribution of cargoes plays a crucial role in determining cell fate and therapeutic efficacy. However, achieving the precise delivery of therapeutics to specific intracellular targets remains a significant challenge. Here, we present a trimodular and acid/enzyme-gated nanoplatform (TAEN) that undergoes disassembly within acidic endosomes and then is cleaved by lysosomal cathepsin B to facilitate efficient and targeted transport of released cargoes into mitochondria compartments.

The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment.

Regulatory T (Treg) cells play key roles in cancer immunity by suppressing a range of antitumor immune responses and contributing to resistance to programmed death (PD)-1 blockade therapy. Given their critical roles in self-tolerance, local control of immunosuppression by Treg cells, such as in the tumor microenvironment (TME), has been intensively studied. Inhibition of heat shock protein 90 (HSP90), a chaperone with vital roles in regulating proteostasis in cancer cells, impedes cancer progression by interrupting oncogenic signaling pathways and potentially modulating antitumor immunity, but we have very little mechanistic insight into these immune modulatory effects.

Two fluorinases prioritized from protein families of fluorinase, SAM-dependent chlorinase and hydroxide adenosyltransferase.

Fluorinases represent the only known biological catalysts capable of forming carbon-fluorine bonds, but their slow catalytic rate limits their broader application. In this study, two fluorinases, FlA and FlA, were identified from a pool of 12 718 nonredundant proteins using a genome-mining approach, with FlA showing high catalytic activity. Both newly identified fluorinases contain a Phe50 residue in place of the Trp50 typically found in fluorinases.

Controlled Hierarchical Construction of Ultrahomogeneous CoS@CoAl-LDH/NF Layered Core-Shell Heterostructures for High-Performance Asymmetric Supercapacitors.

The rational collocation and construction of multiphase composite electrode materials with ingenious structures is a key strategic to enhance the electrochemical performance of supercapacitors (SCs). Within this project, a unique CoS@CoAl-LDH/NF core-shell heterostructure consisting of CoAl-LDH/NF ultrathin nanosheets sturdily attached to CoS/NF needle-like nanorods is grown in situ on self-supported conductive substrate nickel foam (NF) by an effortless and productive multistep hydrothermal method. The construction of the core-shell structure can effectively enhance the capacitive properties as well as the mechanical strength of the material.

Genome-wide analysis of the PYL gene family and identification of PYL genes that respond to cold stress in Triticum monococcum L. Subsp. Aegilopoides.

Abscisic acid (ABA) is a key plant hormone that regulates plant growth and response to stress . Pyrabactin resistance 1-like (PYR/PYL) proteins are ABA receptors involved in the initial steps of ABA signaling. Triticum monococcum L.

The efficacy and safety of herbal formulas for adults with pulmonary hypertension combined with chronic obstructive pulmonary disease: a systematic review and meta-analysis involving 1,865 participants.

Background: There is currently no effective treatment for the majority of patients with chronic obstructive pulmonary disease combined with pulmonary hypertension (COPD-PH). Numerous clinical trials have demonstrated the use of traditional Chinese medicine (TCM) herbal formulas in combination with routine western pharmacotherapy (WP) for the treatment of COPD-PH, with positive results. This meta-analysis was designed to evaluate the efficacy and safety of TCM herbal formulas in the treatment of COPD-PH.

Redesigning glycolaldehyde synthase for the synthesis of biorefinery feedstock D-xylulose from C1 compounds.

Global climate deterioration intensifies the demand for exploiting efficient CO utilization approaches. Converting CO to biorefinery feedstock affords an alternative strategy for third-generation biorefineries. However, upcycling CO into complex chiral carbohydrates remains a major challenge.

Symptom Cluster Assessment Tools for Gastric Cancer Care in China: A Comprehensive Review.

Gastric cancer is a common malignant tumor, and its incidence rate ranks first among malignant tumors of the digestive tract, seriously endangering human physical and mental health. Changes in the physiological state of gastric cancer patients can bring about many physical and psychological symptoms and have a serious impact on their quality of life. Symptom clusters are 2 or more concurrently occurring and interrelated symptoms, with the core symptoms within the cluster remaining stable over time and the symptoms in the cluster being independent of each other.

Developmental variations of the reproductive organs of ganders from different goose breeds and the underlying mechanisms.

A deep understanding of the dynamics and mechanisms of male reproductive tract development is necessary for adoption of either genetic techniques or environmental management practices for improving fertility and hatchability in poultry. However, compared with other poultry such as chickens and ducks, less is known about the age- and breed-related changes in the reproductive tract development of domestic goose ganders exhibiting relatively poor reproductive performance as well as the regulatory mechanisms. In the present study, by taking 2 Chinese domestic goose breeds (Sichuan White goose, SW and Gang goose, GE; Anser cygnoides) and one European goose breed (Landes goose, LD; Anser anser) as the experimental objects, we comprehensive analyzed the morphological, histological, and genome-wide transcriptomic variations in their testicular and external genital development during the period from hatching to sexual maturity.

Health information literacy among children with spinal muscular atrophy and their caregivers.

Background: Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease that leads to multiple organ dysfunction. The advent of disease-modifying treatments makes the early diagnosis of SMA critical. Health information literacy is vital for obtaining, understanding, screening, and using health information.

The tripartite motif-containing 24 is a multifunctional player in human cancer.

Tripartite motif-containing 24 (TRIM24), also known as transcriptional intermediary factor 1α (TIF1α), is the founding member of TIF1 family. Recent evidence indicates that aberrant expression of TRIM24, functions as an oncogene, is associated with poor prognosis across various cancer types. TRIM24 exhibits a multifaceted structure comprising an N-terminal TRIM region with a RING domain, B-box type 1 and type 2 domains, and a coiled-coil region, as well as a C-terminal plant-homeodomain (PHD)-bromodomain.

Safety of risdiplam in spinal muscular atrophy patients after short-term treatment with nusinersen.

Introduction/aims: Following the approval of risdiplam, there are more possibilities for disease-modifying therapy (DMT) in children with spinal muscular atrophy (SMA). Non-treatment-naïve subjects with SMA involved in the JEWELFISH study, designed to evaluate the safety and tolerability of risdiplam, were required to undergo a washout period before receiving risdiplam. This study aims to investigate the safety of administering risdiplam in patients within 90 days of receiving treatment with nusinersen.

Study on Mechanical and Electrical Properties of High Content CNTs/Cu Composites.

It is expected that composites made of carbon nanotubes (CNT) and copper (Cu) display both mechanical and electrical properties, but the low damage dispersion and high-quality composite of high-content CNTs have always been research difficulties. In this paper, high-content CNTs/Cu composites were prepared. The effects of the sintering method, sintering temperature, directional rolling and the CNTs' content on the relative density, hardness and electrical conductivity of the composites were studied.

Value of near-infrared spectroscopy in evaluating the risk of neonatal necrotizing enterocolitis: A systematic review and meta-analysis.

Purpose: Recently, near-infrared spectroscopy (NIRS) has been proposed for diagnosing patients with neonatal necrotizing enterocolitis (NEC). However, a consensus on the credibility of NIRS in evaluating NEC risk has not been reached. This meta-analysis aimed to evaluate the relationship between NEC and splanchnic regional tissue oxygen saturation (SrSO) and cerebral regional tissue oxygen saturation (CrSO) detected by NIRS to clarify the clinical value of NIRS in evaluating the risk of NEC.