Building a Chinese ancient architecture multimodal dataset combining image, annotation and style-model.

In this rapidly evolving era of multimodal generation, diffusion models exhibit impressive generative capabilities, significantly enhancing the realm of creative image synthesis by intricately textual prompts. Yet, their effectiveness is limited in certain niche sectors, like depicting Chinese ancient architecture. This limitation is primarily due to the insufficient data that fails to encompass the unique architectural features and corresponding text information.

Coronavirus M protein promotes mitophagy over virophagy by recruiting PDPK1 to phosphorylate SQSTM1 at T138.

Autophagy plays a dual role in coronavirus infection, facilitating the elimination of either proviral components (virophagy) or antiviral factors such as mitochondria (mitophagy), leading to complex mechanisms of immune evasion. Understanding the mechanisms that govern the switch between the autophagic degradation of deleterious or beneficial substrates in coronavirus infection is crucial for developing precise drug targets to treat virus-induced diseases. However, this switch remains largely unknown.

[Trends and age-period-cohort analysis of leukemia incidence in Qidong from 1972 to 2021].

To describe the epidemiological characteristics and trends of leukemia incidence in Qidong between 1972 and 2021, and provide guidelines for prevention and control measures and strategies. The cancer registry data was collected and analyzed on leukemia incidence during 1972-2021 in Qidong by sex, age and time. Crude incidence rate (CR), China age-standardized rate (ASRC), world age-standardized rate (ASRW), and average annual change percentage (AAPC) was calculated by Joinpoint software.

Enhancing removal performance of ortho xylene by adding polydimethylsiloxane into two-stage biofilter.

A two-stage biofilter was built, augmented with polydimethylsiloxane (PDMS), to enhance the degradation of ortho xylene (o-xylene), and evaluate the feasibility of different PDMS concentrations for improving the removal effect. The results showed that PDMS concentration of 0.50 % significantly enhanced the purification efficiency and mineralization rate of o-xylene to 85(±1)% and 81 %, respectively.

Psychometric Properties and Measurement Equivalence of the Workplace Incivility Scale Across Cultures: Insights from Daily Diary Study.

Despite extensive research on workplace incivility, little attention has been given to its validation in culturally distinct contexts such as China and Pakistan. This study aims to bridge this gap by investigating the psychometric properties of the workplace incivility scale within these cultural frameworks. Additionally, it seeks to explore the cross-cultural measurement equivalence of the workplace incivility scale between these two diverse settings using a daily diary study design.

Structural Characterization, and Antioxidant, Hypoglycemic and Immunomodulatory Activity of Exopolysaccharide from JM-1.

Sanghuang as a medicinal fungus in China has a history of more than 2000 years, and is known as the "forest gold". Most notably, the polysaccharides of sp. have attracted widespread attention due to their significant bioactivity in recent years.

Oroxylin A suppressed colorectal cancer metastasis by inhibiting the activation of the TGF-β/SMAD signal pathway.

Metastatic colorectal cancer continues to have a high fatality rate, with approximately only 14% of patients surviving more than 5 years. To improve the survival rate of these patients, the development of new therapeutic drugs is a priority. In this study, we investigated the effects of Oroxylin A on the metastasis of human colorectal cancer cells and its potential molecular mechanism.

Effect of water and sanitation, PM pollution and climate change of COPD and LRIs under different sociodemographic transitions.

Objectives: To estimate the burden of chronic obstructive pulmonary disease (COPD) and lower respiratory tract infections (LRIs) stratified by geographic location, and social-demographic status for 21 regions across the world from 1990 to 2019.

Study Design: The analysis utilized data from the Global Burden of Disease (GBD) Study, focusing on mortality and disability-adjusted life years (DALYs) as measures of COPD and LRI burden. Trend analyses using the Joinpoint model were conducted across five socio-demographic index (SDI) quintiles.

Double Layer SiO-Coated Water-Stable Halide Perovskite as a Promising Antimicrobial Photocatalyst under Visible Light.

Halide perovskite nanocrystals (HPNCs) have emerged as promising materials for various light harvesting applications due to their exceptional optical and electronic properties. However, their inherent instability in water and biological fluids has limited their use as photocatalysts in the aqueous phase. In this study, we present highly water-stable SiO-coated HPNCs as efficient photocatalysts for antimicrobial applications.

Direct Carbapenem Resistance and Carbapenemases Genotype Prediction by Al-MOF/TiO@Au Cubic Heterostructures-Assisted Intact Bacterial Cells Metabolic Analysis.

Carbapenem-resistant (CRKP) infections pose a significant threat to human health. Fast and accurate prediction of carbapenem resistance and carbapenemase genotype is critical for guiding antibiotic treatment and reducing mortality rates. In this study, we present a novel method using Al-MOF/TiO@Au cubic heterostructures for the metabolic analysis of intact bacterial cells, enabling rapid diagnosis of CRKP and its carbapenemases genotype.

Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999-2018.

Background: Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) is an emerging composite assessment tool for dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with CKD prevalence in MetS in this national cross-sectional analysis.

Enhancing retention and permeation of rapamycin for osteoarthritis therapy using a two-stage drug delivery system.

Osteoarthritis (OA) remains a challenging degenerative joint disease, largely associated with chondrocyte apoptosis during its development. Preserving chondrocytes stands as a promising strategy for OA treatment. Rapamycin (RP) exhibits chondrocyte protection by fostering autophagy.

Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes.

Wingless (Wg)/Wnt signaling plays a critical role in both development and adult tissue homeostasis. In the Drosophila larval wing disc epithelium, the orderly delivery of Wg/Wnt to the apical and basal cell surfaces is essential for wing development. Here, we identified Ehbp1 as the switch that dictates the direction of Wg/Wnt polarized intracellular transport: the Adaptor Protein complex 1 (AP-1) delivers Wg/Wnt to the basolateral cell surface, and its sequestration by Ehbp1 redirects Wg/Wnt for apical delivery.