Publications by authors named "Yan Xuechuan"
Background: The standard of care for upper tract urothelial carcinoma (UTUC) traditionally involved open nephroureterectomy with bladder cuff excision. Despite the adoption of transabdominal laparoscopic one-stage nephroureterectomy to mitigate this, the persistently high rate of postoperative intestinal obstruction remains a clinical challenge. This study introduces an innovative approach: a single-position, completely retroperitoneal laparoscopic nephroureterectomy coupled with a 75-45-degree positional change for bladder cuff resection in the treatment of UTUC.
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- - Recent research indicates a possible connection between gut microbiota and bladder cancer (BCa), but how they interact and affect metabolic processes is still unclear.
- - Using genomic data and Mendelian randomization, the study found that specific gut bacteria, particularly the genus Bilophila, are causally linked to BCa, with significant metabolic pathways influencing its development.
- - The findings suggest that targeting gut microbiota and their metabolic pathways could lead to new prevention and treatment strategies for BCa, highlighting the role of microbiota in precision medicine.
Article Synopsis
- * CISD3's expression is positively linked to immune cell infiltration in certain cancers, serving as both a protective and risk factor, especially in renal cell carcinoma where it acts as an independent prognostic marker.
- * Pathway analysis reveals CISD3's involvement in cancer processes like proliferation inhibition, and experiments show that overexpressing it disrupts mitochondrial function and promotes cell damage, suggesting its potential as both a biomarker and a therapeutic target in cancer treatment.
One of the ways in which macrophages support tumorigenic growth is by producing adenosine, which acts to dampen antitumor immune responses and is generated by both tumor and immune cells in the tumor microenvironment (TME). Two cell surface expressed molecules, CD73 and CD39, boost catalytic adenosine triphosphate, leading to further increased adenosine synthesis, under hypoxic circumstances in the TME. There are four receptors (A1, A2A, A2B, and A3) expressed on macrophages that allow adenosine to perform its immunomodulatory effect.
View Article and Find Full Text PDF[Reconstruction of large through-and-through palate defects with folded free forearm flap].
Zhonghua Zheng Xing Wai Ke Za Zhi
November 2008
Objective: To explore the reconstruction method of large through-and-through palate defects.
Methods: From 2003 to 2006, 7 cases of large through-and-through palate defects were reconstructed with vascularized folded free forearm flap. 8 flaps were used, including 7 free forearm flaps and 1 pectoralis major myocutaneous flap.