Aim: Dynamic cancer control is a current health system priority, yet methods for achieving it are lacking. This study aims to review the application of system dynamics modeling (SDM) on cancer control and evaluate the research quality.
Methods: Articles were searched in PubMed, Web of Science, and Scopus from the inception of the study to November 15th, 2023.
Directional wetting of liquids on solid surfaces is crucial for numerous applications. However, the impact of physical modifications on near-superhydrophilic cellulose has received limited attention as it is widely considered unfeasible. In this study, we present a previously unreported and simple but effective mechanism of directional wetting induced purely by physical modifications on pristine cellulose surfaces.
View Article and Find Full Text PDFObjectives: As an innovative technology, internet hospitals have the potential to improve healthcare services. However, the pioneering nature of internet hospitals means that they are still in the early stages of development. This study aimed to investigate the challenges and strategies involved in establishing internet hospitals by public medical institutions in China.
View Article and Find Full Text PDFThe design of multifunctional, high-performance wearable heaters utilizing textile substrates has garnered increasing attention, particularly in the development of body temperature and health monitoring devices. However, fabricating these multifunctional wearable heaters while simultaneously ensuring flexibility, air permeability, Joule heating performance, electromagnetic interference (EMI) shielding and antibacterial properties remains a significant challenge. This study utilizes phase transition lysozyme (PTL) film-mediated electroless deposition (ELD) technology to deposit silver nanoparticles (Ag NPs) on the cotton fabrics surface in a mild aqueous solution at room temperature, thereby constructing a wearable heater with long-term stability, high conductivity, and exceptional photothermal properties.
View Article and Find Full Text PDFComp Biochem Physiol B Biochem Mol Biol
December 2024
Lysozymes are crucial enzymes involved in the innate immune response against bacterial pathogens. In this study, we identified and characterized a goose-type lysozyme gene (SsLyG) from the black rockfish Sebastes schlegelii, an economically important aquaculture species. The deduced amino acid sequence of SsLyG contains 495 residues, which inculded a signal peptide, an immunoglobulin domain, and a goose egg-white lysozyme (GEWL) domain.
View Article and Find Full Text PDFCognitive impairment associated with schizophrenia (CIAS) is considered a core symptom of the illness, yet effective treatments remain limited. Light plays an important role in regulating cognitive functions. However, the potential of light treatment (LT) to improve CIAS remains unknown.
View Article and Find Full Text PDFFerroptosis is a novel type of programmed cell death caused by excessive iron-dependent lipid peroxidation. According to various studies, there may be a link between ferroptosis and lipid metabolism. However, few studies have been reported on the lipid metabolism of ferroptosis in acute myeloid leukemia (AML).
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
November 2024
The objective of image fusion is to integrate complementary features from source images to better cater to the needs of human and machine vision. However, existing image fusion algorithms predominantly focus on enhancing the visual appeal of the fused image for human perception, often neglecting their impact on subsequent high-level visual tasks, particularly the processing of semantic information. Moreover, these fusion methods that incorporate downstream tasks tend to be overly complex and computationally intensive, which is not conducive to practical applications.
View Article and Find Full Text PDFQingdai (QD), derived from various plant sources, is commonly used in traditional Chinese medicine for ulcerative colitis (UC) treatment. However, the clinical efficacy and mechanisms of orally administered QD remain unclear. This study aims to evaluate QD's efficacy in UC treatment and uncover its active components and mechanisms.
View Article and Find Full Text PDFTyphoon-induced perturbations can result in long-lasting effects on aquatic communities in subtropical lakes or reservoirs. However, the responses of bacterial communities and their related nutrient cycling to episodic typhoon events throughout the water column in deep waters remain largely unknown. Here, we conducted a four-year field study to reveal the depth-specific responses of both free-living (FL) and particle-attached (PA) bacteria to typhoon events in a subtropical deep reservoir from 2015 to 2018.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
November 2024
The aim of this study was to explore the efficacy and safety of Trastuzumab-Deruxtecan (T-DXd) in metastatic breast cancer (mBC). This retrospective observational study was conducted between January 2021 and 2023. Patients' clinical and pathological characteristics and previous medicinal treatments were reviewed.
View Article and Find Full Text PDFThis study aims to investigate the effects of early speech and language cognitive training on the nursing outcomes of children with language impairments and their impact on developmental quotient. From October 2018 to October 2023, the data of 80 children with language impairments treated at our hospital were selected. They were divided into an observation group (n = 40) and a control group (n = 40) based on the treatment plan.
View Article and Find Full Text PDFAutosomal recessive spinocerebellar ataxias (SCARs) are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation (c.
View Article and Find Full Text PDFBackground: The causal relationship between cathepsins and neurological diseases remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) approach to assess the potential causal effect of cathepsins on the development of neurological diseases.
Methods: This study conducted a two-sample two-way MR study using pooled data from published genome-wide association studies to evaluate the relationship between 10 cathepsins (B, D, E, F, G, H, L2, O, S, and Z) and 7 neurological diseases, which included ischemic stroke, cerebral hemorrhage, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and epilepsy.
Stripe rust, caused by f. sp. (), stands out as one of the most devastating epidemics impacting wheat production worldwide.
View Article and Find Full Text PDFBackground: The optimal sedative regime for noninvasive ventilation (NIV) intolerance remains uncertain. The present study aimed to assess the efficacy and safety of remifentanil (REM) compared to dexmedetomidine (DEX) in cardiac surgery patients with moderate-to-severe intolerance to NIV.
Methods: In this multicenter, prospective, single-blind, randomized controlled study, adult cardiac surgery patients with moderate-to-severe intolerance to NIV were enrolled and randomly assigned to be treated with either REM or DEX for sedation.
Background: Rheumatic heart disease (RHD) is an autoimmune disease caused by recurrent infections of Group A streptococcus (GAS), ultimately leading to inflammation and the fibrosis of heart valves. Recent studies have highlighted the crucial role of C-C chemokine receptor type 2-positive (CCR2) macrophages in autoimmune diseases and tissue fibrosis. However, the specific involvement of CCR2 macrophages in RHD remains unclear.
View Article and Find Full Text PDFAs the negative repercussions of environmental devastation, such as air quality decline and air pollution, become more apparent, environmental consciousness is growing across the world, forcing nations to take steps to mitigate the damage. China pledged to achieve air quality improvement goal to combat global environment issue, yet the spatial-temporal differentiation and its driving factors of environment-meteorology-economic index for air quality are not fully analysed. To promote regional collaborative control of air pollution and achieve sustainable urban development, spatial and temporal different and its driving factors of air quality in Shandong Province during 2013-2020.
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