Publications by authors named "Yan Xiang Zang"
Methods: Overall, 18 rabbits were randomly divided into control, pacing (600 beats/min), and pacing+sac/val groups. The rabbits in the pacing+sac/val cohort received oral sac/val (10 mg/kg twice daily) across the 21-day investigation period. After three weeks, the atrial effective refractory period (AERP) and AF induction rate were compared.
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- Atrial metabolic remodeling is crucial for the development of atrial fibrillation (AF), and Sirtuin3 (Sirt3) is important for maintaining energy balance in the heart.
- The study investigates the effects of the Sirt3 agonist Honokiol (HL) on atrial metabolic changes in AF by examining its influence on metabolic factors, ATP levels, and enzyme activities in both rabbit and cell models.
- Results show that HL restores Sirt3 levels and counteracts the metabolic abnormalities associated with AF, suggesting a potential new treatment approach for managing atrial fibrillation.
Atrial structural and electrical remodelling play important roles in atrial fibrillation (AF). Sacubitril/valsartan attenuates cardiac remodelling in heart failure. However, the effect of sacubitril/valsartan on AF is unclear.
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