Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis.

Alveolar macrophages (AMs) are crucial for lung homeostasis, and their dysfunction causes uncontrolled fibrotic responses and pulmonary disorders. Protein phosphatases control multiple cellular events. However, whether nuclear phosphatases cooperate with histone modifiers to affect pulmonary fibrosis progress remains obscure.

Mast cell leukemia: a rare case report and literature review.

Mast cell leukemia (MCL) is an extremely rare and aggressive hematologic malignancy, characterized by a poor prognosis and short survival. Currently, no standardized treatment guidelines have been established. This study presents the clinical data of a patient with primary MCL accompanied by C-findings, and analyzes the clinical features, diagnostic challenges, and therapeutic approaches for this disease through a comprehensive review of the relevant literature.

Comparison of the polluted dust plume and natural dust air mass in a spring dust event in Beijing 2023.

The occurrence of extreme weather events is becoming more frequent due to global climate change. A long-lasting dust outbreak in the spring of 2023 was triggered by Mongolia cyclones and cold fronts in the dust source areas. In this study, we illustrate the spatial distribution, the transport path of the dust and its influence on the air quality of downstream cities utilizing ground-based and space-borne measurements.

Medium- and long-term outcomes of tunneled labial mucosa tube grafts for the repair of primary severe hypospadias and failed hypospadias.

Objective: This study aimed to evaluate the medium and long-term outcomes of tunneled labial mucosa tube graft urethroplasty in the treatment of primary severe hypospadias and failed hypospadias.

Methods: We retrospectively reviewed the medical records of the patients who underwent tunneled labial mucosa tube graft urethroplasty at a single center between 2007 and 2020. Data collected included patient demographic, operative and post-operative characteristics.

The Effects of Different Cotton Varieties on the Growth and Feeding Preferences of .

Xinjiang is an autonomous province in northwest China [...

Open Hollow Nut-like Co-Pt Decorated with CoPt@C for Enhanced Hydrogen Evolution Reaction.

Constructing an efficient open hollow nut-like Co-MOF/Pt-based electrocatalyst via a partial etching strategy remains challenging. In this study, a novel concurrent thermal polymerization-etching strategy is introduced to prepare a unique open hollow nut-like Co-Pt decorated with a CoPt@C layer electrocatalyst (denoted as Co-Pt/CoPt@C), exhibiting outstanding hydrogen evolution reaction performance. In Co-Pt/CoPt@C, the distinctive open hollow nut-like Co-Pt structure is encapsulated within a CoPt@C layer.

Genomic characteristics and phylogenetic analyses of colonization and infection with carbapenem-resistant in multicenter intensive care units: a cohort study.

Unlabelled: Carbapenem-resistant () poses a major threat to global public health. This study aimed to investigate the genomic characteristics and phylogenetic relatedness of colonization and infection with among intensive care unit (ICU) patients. A total of 61 isolates, including 29 non-ICU-acquired and 32 ICU-acquired strains, were collected by active screening and infection culture from 16 ICUs through a multicenter cohort study.

Shipborne lidar measurements of ozone over the southeastern coastal regions of China in winter.

Ozone observations over oceanic areas remain inadequate or even non-existent in some areas, thus preventing the effective mitigation of the regional O pollution problem. Shipborne lidar measurements were conducted to investigate the distribution and transport of ozone over the southeastern coastal regions of China during the winter of 2024. The measurements were performed along the southeast coast of China from Zhejiang (ZJ) to Hong Kong (HK).

Bimetallic Metal-Organic Framework Catalyst to Accelerate Sulfur Conversion Kinetics for High-Performance Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries are highly attractive due to their exceptional theoretical energy density (2600 Wh kg) and low cost. However, their practical deployment is limited by critical issues, including pronounced polysulfide shuttling and slow reaction kinetics. In this study, we report the development of a novel Mo-Zn bimetallic ZIF-8 catalyst designed to address these issues.

A case report of successful treatment of advanced thymic squamous cell carcinoma with poor performance status using multimodal therapy.

Thymic squamous cell carcinoma (TSCC) is a rare yet aggressive tumor associated with a dismal prognosis. The patient, a 76-year-old male, presented with symptoms of fatigue, bloody sputum and dyspnea. Computed tomography (CT) and positron emission tomography/computed tomography (PET/CT) scans demonstrated a significant mass in the chest, accompanied by metastasis to adjacent lymph nodes.

Diagnostic Accuracy of Uroflowmetry for Urethral Strictures in Pediatric Hypospadias: TIP vs. Non-TIP Outcomes.

Introduction: To evaluate the diagnostic accuracy of uroflowmetry in detecting pediatric urethral strictures following Tubularized Incised-Plate (TIP) and non-TIP urethroplasty.

Materials And Methods: A retrospective cohort study was conducted on children who underwent primary hypospadias repairs from June 2016 to June 2023 at our institution. Patients were categorized into the TIP and the non-TIP groups.

Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome.

Drug targets supported by genetic evidence with a several-fold higher probability of success in clinical trials. We performed a comprehensive proteome-wide Mendelian randomization (MR) analysis to identify causal proteins and potential therapeutic targets for four site-specific cancers. A total of 13,248 protein quantitative trait loci for 4853 plasma proteins were utilized for proteome-wide MR analysis.

Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial.

Objectives: Postoperative nausea and vomiting (PONV) is common after video-assisted thoracic surgery, which may be associated with the use of intraoperative opioids. We tested the hypothesis that balanced opioid-free anesthesia (OFA) might reduce the incidence of PONV after video-assisted thoracic surgery.

Methods: One hundred and sixty-eight adults undergoing video-assisted thoracic assisted surgery were randomly assigned to receive balanced opioid-free anesthesia or balanced opioid-based anesthesia (OBA).

Endogenous peptide CBDP1 inhibits clear cell renal cell carcinoma progression by targeting USP5/YTHDF2/TRPM5 axis.

Background: Clear cell renal cell carcinoma (ccRCC) has a high incidence rate and poor prognosis, and currently lacks effective therapies. Recently, peptide-based drugs have shown promise in cancer treatment. In this research, a new endogenous peptide called CBDP1 was discovered in ccRCC and its potential anti-cancer properties were examined.

Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.

Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report a novel fusion gene and investigate its pathogenic role in acute lymphoblastic leukemia (ALL). We engineer a transposon transfection system expressing the TOP2B::AFF2 transcript and introduce it into Ba/F3 cells.

Nanoscale interaction mechanism between bubbles and microplastics under the influence of natural organic matter in simulated marine environment.

Bubble-microplastic (MP) interaction is a significant process that changes the routes of MP circulation in marine environment and thereby determines the risk of MPs, which could be strongly influenced by natural organic matter (NOM) in oceans. However, the quantitative interaction mechanisms between bubbles and MPs under the effect of NOM remain elusive. Herein, bubble-MP interactions in simulated seawater were quantified at nanoscale based on atomic force microscope coupled with the Stokes-Reynold-Young-Laplace model.

Synergetic Interface and Bulk Defects Modification with Identical Organic Molecule for Efficient Inverted Perovskite Solar Cells.

Recent progress in inverted perovskite solar cells (IPSCs) mainly focused on NiO modification and perovskite (PVK) regulation to enhance efficiency and stability. However, most works address only monofunctional modifications, and identical molecules with the ability to simultaneously optimize NiO interface and perovskite bulk phase have been rarely reported. This work proposes a dual modification approach using 4-amino-3,5-dichlorobenzotrifluoride (DCTM) to optimize both NiO upper interfaces and reduction of bulk defects in perovskite.

Network-Based Methods for Deciphering the Oxidizability of Complex Leachate DOM with OH/O via Molecular Signatures.

In landfill leachates containing complex dissolved organic matter (DOM), the link between individual DOM constituents and their inherent oxidizability is unclear. Here, we resolved the molecular signatures of DOM oxidized by OH/O using FT-ICR MS, thereby elucidating their oxidizability and resistance in concentrated leachates. The comprehensive gradual fragmentation of complex leachate DOM was then revealed through a modified machine-learning framework based on 43 key pathways during ozonation.

Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line.

This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique case of compound heterozygous deleterious mutations in the GRHPR gene, specifically the intron2/3 c.214-2 T > G and the exon8 c.864-865delTG, leading to a premature stop codon at p.

Nanoscale insight into the interaction mechanism underlying the transport of microplastics by bubbles in aqueous environment.

The ecological risk of microplastics (MPs) is raising concern about their transport and fate in aquatic ecosystems. The capture of MPs by bubbles is a ubiquitous natural phenomenon in water-based environment, which plays a critical role in the global cycling of MPs, thereby increasing their environmental threats. However, the nanoscale interaction mechanisms between bubbles and MPs underlying MPs transport by bubbles in complex environmental systems remain elusive.

Metabolic Reprogramming of Macrophages by Biomimetic Melatonin-Loaded Liposomes Effectively Attenuates Acute Gouty Arthritis in a Mouse Model.

Gouty arthritis is characterized by an acute inflammatory response triggered by monosodium urate (MSU) crystals deposited in the joints and periarticular tissues. Current treatments bring little effects owing to serious side effects, necessitating the exploration of new and safer therapeutic options. Macrophages play a critical role in the initiation, progression, and resolution of acute gout, with the cellular profiles closely linked to their activation and polarization.

Study on molecular response of alfalfa to low temperature stress based on transcriptomic analysis.

Background: Alfalfa (Medicago sativa L.) is an important high-quality forage crop. Low temperature is an abiotic stress factor that affects the distribution and productivity of alfalfa.

Noninvasive early identification of durable clinical benefit from immune checkpoint inhibition: a prospective multicenter study (NCT04566432).

Immune checkpoint inhibitors (ICIs) have changed the treatment landscape for patients with non-small cell lung cancer (NSCLC). In spite of durable responses in some patients, many patients develop early disease progression during the ICI treatment. Thus, early identification of patients with no durable benefit would facilitate the clinical decision for these patients.

LRP1B Suppresses Immunotherapy Efficacy in Lung Adenocarcinoma by Preventing Ferroptosis.

Background: Immune biomarkers for non-small-cell lung cancer (NSCLC) are programmed death ligand 1 (PD-L1) and tumor mutational burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy. Identifying appropriate biomarkers that can differentiate between beneficiary groups is imperative.

Investigating the Impact of Host Factors on Vaccinia Virus Infection Through Single-Cell Analysis via Flow Cytometry.

To investigate the impact of a host factor on viral replication, conventional techniques involve analyzing viral replication within a homogeneous cell population engineered to uniformly express the host factor. In this chapter, we present a method to explore the intricate dynamics between host factors and vaccinia virus (VACV) infection using flow cytometry, which enables the rapid, multi-parametric analysis of individual cells in solution. Cultured cells are transfected to express a host factor fused with a fluorescent protein, followed by infection with a VACV encoding a different fluorescent reporter.