Publications by authors named "Yan Weigang"
Article Synopsis
- Overbiopsy is a significant concern in prostate cancer diagnostics, prompting the development of a new urine tumor DNA algorithm called utLIFE to help avoid unnecessary procedures.
- In clinical tests with a training group and a validation cohort, the utLIFE-PC model demonstrated high accuracy with an area under the curve (AUC) of 0.967 and 0.929, respectively, along with strong sensitivity and specificity.
- The model outperforms traditional prostate-specific antigen (PSA) tests and other single-dimensional biomarkers, highlighting its potential to enhance prostate cancer diagnostics and reduce unnecessary biopsies.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Fig. 3B on p. 839 were strikingly similar to data that had already appeared in another article written by different authors at different research institutes [Mao Y, Zhang L, Yuan L, Yan M and He Y: MiR‑218 suppresses cell progression by targeting APC in cervical cancer.
View Article and Find Full Text PDFPurpose: This study aims to investigate the association between Body Mass Index (BMI) and sex hormone levels utilizing a cross-sectional study design alongside Mendelian randomization (MR) analysis.
Materials And Methods: A cross-sectional study was performed based on National Health and Nutrition Examination Survey (NHANES) 2013-2016. Additionally, a two-sample MR analysis was performed, utilizing Single Nucleotide Polymorphisms (SNPs) associated with BMI identified in a genome-wide association study (GWAS) comprising 339224 individuals.
Article Synopsis
- The KangDuo Surgical Robot (KD-SR) was tested against the da Vinci Si Surgical System (DV-SS-Si) for safety and effectiveness in robot-assisted radical prostatectomy (RARP) for prostate cancer patients.
- A study involved 80 patients, showing that both robots achieved a 100% surgical success rate and similar urinary continence outcomes, although the KD-SR had a longer median operation time.
- Overall, the KD-SR demonstrated comparable short-term results, making it a viable alternative to the DV-SS-Si for prostate cancer surgeries, but the study faced limitations like a short follow-up period.
Background: This study evaluates the efficacy of a nomogram for predicting the pathology upgrade of apical prostate cancer (PCa).
Methods: A total of 754 eligible patients were diagnosed with apical PCa through combined systematic and magnetic resonance imaging (MRI)-targeted prostate biopsy followed by radical prostatectomy (RP) were retrospectively identified from two hospitals (training: 754, internal validation: 182, internal-external validation: 148). A nomogram for the identification of apical tumors in high-risk pathology upgrades through comparing the results of biopsy and RP was established incorporating statistically significant risk factors based on univariable and multivariable logistic regression.
Leuprorelin acetate microspheres, a common gonadotropin-releasing hormone agonist, have certain clinical benefits for prostate cancer (PCa). The present study aimed to compare the efficacy and safety of generic and branded leuprorelin acetate microspheres in patients with PCa. The present retrospective, observational study included 116 patients with PCa who received generic (Boennuokang; Beijing Biote Pharmaceutical Co.
View Article and Find Full Text PDFArticle Synopsis
- Adrenal hemangioma (AH) is a rare, benign tumor of the adrenal gland, primarily found incidentally during imaging studies, with this study seeking to shed light on its clinical traits and imaging features.
- A retrospective analysis at Peking Union Medical College Hospital identified 40 cases of AH among 7140 adrenal tumor patients, mostly affecting middle-aged women, with 70% being asymptomatic and commonly misdiagnosed as other conditions like pheochromocytoma.
- The findings highlighted specific imaging characteristics and recommended laparoscopic adrenalectomy as the main treatment, emphasizing the importance of accurate diagnosis to enhance patient outcomes.
Background: Without a pseudocapsule, prostate cancer is invasive in volume growth and has some regularity in spatial distribution. Our study aims to explore the specific origin location, invasive characteristics, and morphology of prostate cancer.
Methods: Ninety-eight clinical specimens with tumor volume equal to or less than one-third of the organ volume and 111 autopsy specimens were retrospectively analyzed.
Background: Researchers have shown that using next-generation hormonal agents (NHA) for castration-resistant prostate cancer (CRPC) would lead to increased risk of cardiac adverse effects, making clinician choices more complex.
Methods: We systematically searched Pubmed, Cochrane Library, and Embase databases for research published before October 2022. Agents were ranked according to their effectiveness based on cardiac adverse effects using the surface under the cumulative ranking curve.
This study aimed to construct nomograms for predicting the likelihood of clinically significant prostate cancer (csPCa) in patients with lesions rated as Prostate Imaging Reporting and Data System (PI-RADS) 3 on biparametric magnetic resonance imaging (bpMRI). We retrospectively analyzed a cohort of 457 patients from the Peking Union Medical College Hospital (January 2017-July 2021) to develop the model and externally validated it with a cohort of 238 patients from the Second Hospital of Tianjin Medical University (September 2017-September 2021). Univariate and multivariate logistic regression analyses identified significant predictors of csPCa, defined by tumor volumes ≥ 0.
View Article and Find Full Text PDFProstate cancer detected by autopsy is named latent prostate cancer. As the repertoire of clinical prostate cancer, latent cancer may better reflect the disease burden. Unlike clinical prostate specimens, which are obtained exclusively from biopsy-positive cases, prostate specimens obtained through autopsy provide information on biopsy-negative cases, helping calculate the true sensitivity of prostate biopsy.
View Article and Find Full Text PDFPurpose: To evaluate the diagnostic ability of mpMRI, Ga-PSMA PET/CT and mpMRI combined with Ga-PSMA PET/CT in detecting and localizing lesions, and further clarify the accuracy of these examinations in tumor staging.
Methods: Seventy patients who underwent mpMRI, Ga-PSMA PET/CT and radical prostatectomy were enrolled. The abilities to detect index and clinically significant lesions by three examinations were compared.
Introduction: Correlation between zonal origin of clinically localized prostate cancer (PC) and biochemical recurrence (BCR) after treatment is still controversial.
Methods: We performed a meta-analysis of published articles to investigate the prognostic value of zonal origin in clinically localized PC. Literature was searched from Medline, Embase, Scopus, and Web of Science, from inception to Nov 1st, 2022.
Prostate cancer (PCa) faces great challenges in early diagnosis, which often leads not only to unnecessary, invasive procedures, but to over-diagnosis and treatment as well, thus highlighting the need for modern PCa diagnostic techniques. The review aims to provide an up-to-date summary of chronologically existing diagnostic approaches for PCa, as well as their potential to improve clinically significant PCa (csPCa) diagnosis and to reduce the proliferation and monitoring of PCa. Our review demonstrates the primary outcomes of the most significant studies and makes comparisons across the diagnostic efficacies of different PCa tests.
View Article and Find Full Text PDFBackground: This study aims to compare the clinical outcomes after performing radical prostatectomy (RP) or low-dose-rate brachytherapy (LDR) for patients with intermediate-risk prostate cancer (IRPC).
Methods: We performed a retrospective analysis on 361 IRPC patients who underwent treatment in Peking Union Medical College Hospital from January 2014 to August 2021, of which 160 underwent RP and 201 underwent Iodine-125 LDR. Patients were followed in clinic monthly during the first three months and at three-month intervals thereafter.
Purpose: We aimed to compare the diagnostic performance and biodistribution of two similar PET agents, [Ga]Ga-P16-093 and [Ga]Ga-PSMA-11, in the same group of primary prostate cancer (PCa) patients.
Methods: Fifty patients with untreated, histologically confirmed PCa by needle biopsy were enrolled. Each patient underwent [Ga]Ga-P16-093 and [Ga]Ga-PSMA-11 PET/CT within a week.
Background: Papillary Renal Neoplasm (PRN) with polarity inversion is a less common subtype of kidney cancer with an apparently recognizable morphology, distinct immunohistochemical profiles, and frequent mutations. It has been estimated to account 4% of previously diagnosed PRN.
Case Presentation: This is a retrospective case report of two patients diagnosed with PRNRP.