Publications by authors named "Yan Wan"

Tartary buckwheat is characterized by its numerous inflorescences; however, the uneven distribution of resources can lead to an overload in certain areas, significantly limiting plant productivity. Plant growth regulators effectively modulate plant growth and development. This study investigated the effects of three concentrations of brassinosteroids (EBR) on the Tartary buckwheat cultivar with high seed-setting rates, specifically Chuanqiao No.

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Intramolecular singlet fission (SF) in multichromophore systems is of high interest for photovoltaic application. As an attractive candidate for SF-based devices, enabling efficient SF in covalent oligomers of perylene diimide (PDI) still remains challenging. In this work, inter-PDI SF with τ = ∼150 ps and ∼150% triplet yield in a covalent tetramer COTh-FPDI was facilitated by employing a saddle-shaped cyclooctatetrathiophene (COTh) core and fused linking with PDIs.

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Delayed fluorescence (DF) is a unique emitting phenomenon of great interest for important applications in organic optoelectronics. In general, DF requires well-separated frontier orbitals, inherently corresponding to charge transfer (CT)-type emitters. However, facilitating intrinsic DF for local excited (LE)-type conjugated emitters remains very challenging.

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Photoinduced intramolecular charge separation in a pyrene- and triarylamine-based donor-acceptor dyad was studied by polarization-dependent femtosecond time-resolved transient absorption (TA) spectroscopy in polar solvents. Photoexcitation forms an excited state with charge transfer (CT) character due to the intrinsic electronic coupling between the triarylamine and pyrene groups, resulting in ultrafast charge separation (CS) in polar solvents. TA measurements reveal a correlation between the rate of CS and solvation dynamics, which implies that solvation is involved in the CS reaction.

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Liposomes have demonstrated great potential for drug delivery and diabetes treatment. However, hydrolysis by enzymes and emulsification by endogenous bile salts make liposomes unstable in the gastrointestinal tract. In this study, sodium tauroursodeoxycholate (TUDCNa)-based multifunctional bilosomes were designed to address the deficiencies of conventional liposomes.

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Unmanned aerial vehicles (UAVs) are effective tools for identifying road anomalies with limited detection coverage due to the discrete spatial distribution of roads. Despite computational, storage, and transmission challenges, existing detection algorithms can be improved to support this task with robustness and efficiency. In this study, the K-means clustering algorithm was used to calculate the best prior anchor boxes; Faster R-CNN (region-based convolutional neural network), YOLOX-s (You Only Look Once version X-small), YOLOv5-s, YOLOv7-tiny, YOLO-MobileNet, and YOLO-RDD models were built based on image data collected by UAVs.

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Protein A and Protein L affinity chromatographies are extensively used in mAb and bispecific antibody (bsAb) purification. In addition to product capture, they are both capable of separating certain product-related by-products and aggregates under appropriate conditions. For both types of chromatography, previous studies suggested that adding a salt additive to the mobile phase can significantly improve the resolution between product and by-products/aggregates.

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Article Synopsis
  • The rate of triplet state generation in heavy-atom-free organic molecules can be greatly increased (up to 10^10 times) through a process called spin-orbit charge-transfer intersystem crossing (SOCT-ISC), which relies on charge recombination mechanisms.
  • In this study, researchers investigated the behavior of specific organic compounds (arylsubstituted boron-dipyrromethene dyads) using time-resolved spectroscopy to understand how different factors affect the efficiency of triplet state generation.
  • The findings indicate that the energy levels of electron donors and solvent effects play key roles in determining the Gibbs free energy changes during electron transfer processes, which in turn impact the rates of charge recombination and triplet quantum yields
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Objective: To reveal the role and mechanism of cannabinoid receptor 1 (CB1) and mitochondria in promoting osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in the inflammatory microenvironment.

Methods: Bidirectional mitochondrial transfer was performed in bone mesenchymal stem cells (BMSCs) and PDLSCs. Laser confocal microscopy and quantitative flow cytometry were used to observe the mitochondrial transfer and quantitative mitochondrial transfer efficiency.

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Ethnopharmacological Relevance: Yajieshaba (YJSB), approved by the Yunnan Provincial Food and Drug Administration in 2008, are known for their anti-inflammatory, antiviral, and pro-apoptotic properties, effectively treating Hepatic fibrosis (HF). However, its mechanism of action remains unclear.

Aim Of The Study: The objective of this investigation is to explore how YJSB influences the TGF-β1/Smad signaling pathway as a strategy for reducing HF.

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Tartary buckwheat sprouts are highly valued by consumers for their superior nutritional content. Ionic titanium (Ti) has been shown to enhance crop growth and improve nutritional quality. However, there is limited research on the impact of ionic Ti on the nutritional quality of Tartary buckwheat sprouts.

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  • Gouty nephropathy (GN) is a kidney condition caused by high uric acid levels due to factors like excessive purine intake and metabolic disorders, leading to crystal buildup in kidney tissue.
  • DaiTongXiao (DTX), a traditional remedy from the Dai people in China, shows promise in reducing uric acid levels and has anti-inflammatory and kidney-protective effects.
  • In a rat model of GN, DTX treatment improved kidney function and structure, decreased serum inflammatory markers, and inhibited the TLR4/MyD88/NF-κB signaling pathway, indicating its potential as a therapeutic option for GN.
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In recombinant protein purification, differences in isoelectric point (pI)/surface charge and hydrophobicity between the product and byproducts generally form the basis for separation. For bispecific antibodies (bsAbs), in many cases the physicochemical difference between product and byproducts is subtle, making byproduct removal considerably challenging. In a previous report, with a bsAb case study, we showed that partition coefficient (K) screening for the product and byproducts under various conditions facilitated finding conditions under which effective separation of two difficult-to-remove byproducts was achieved by anion exchange (AEX) chromatography.

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  • Protein A resins are essential for purifying antibodies and can also bind to the VH3 domain, which allows for the separation of byproducts with the same Fc region but different VH3 counts.
  • This study investigates how different VH3-binding Protein A resins perform in separating these antibody species.
  • The methodology involves using specific chromatography techniques and SDS-PAGE to evaluate the effectiveness of five different VH3-binding resins in distinguishing between a full product and a truncated byproduct.
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  • Tartary buckwheat is a drought-resistant crop valued for its nutritional benefits, but drought after flowering reduces its yield significantly.
  • This study compared two genotypes of Tartary buckwheat to see how they responded to drought stress, focusing on growth and physical characteristics.
  • Results showed that the 'Xiqiao-2' genotype had better long-term drought tolerance and could prevent oxidative damage, while 'Dingku-1' performed well under short-term drought and improved after rewatering.
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Untethered microrobots offer the possibility to perform medical interventions in anatomically complex and small regions in the body. Presently, it is necessary to access the upper urinary tract to diagnose and treat Upper Tract Urothelial Carcinoma (UTUC). Diagnostic and treatment challenges include ensuring adequate tissue sampling, accurately grading the disease, achieving completeness in endoscopic treatment, and consistently delivering medications to targeted sites.

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Ethnopharmacological Relevance: Allergic rhinitis (AR) stands as a non-infectious inflammatory condition affecting the nasal mucosa, marked by bouts of sneezing, nasal itching, and congestion. This ailment afflicts individuals across all age groups and poses challenges for effective treatment due to its chronic nature. Cangerzisan (CEZS), documented in the Jishengfang compendium, represents a traditional Chinese medicinal formula long utilized for AR management.

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In order to obtain a long-lived charge separation (CS) state in compact electron donor-acceptor molecular systems, we prepared a series of naphthalenediimide (NDI)-phenothiazine (PTZ) triads, with phenylene as the linker between the donor and acceptor. Conformation restriction is imposed to control the mutual orientation of the NDI and PTZ units by attaching methyl groups on the phenylene linker to tune the electronic coupling between the donor and the acceptor. Moreover, the PTZ moiety was oxidized to sulfoxide to tune the ordering of the CS state and the LE state (LE: locally excited state).

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Quinoa ( Willd) is widely regarded as a versatile pseudo-cereal native to the Andes Mountains in South America. It has gained global recognition as a superfood due to its rich nutritional profile. While quinoa grains are well-known, there is an undiscovered potential in quinoa greens, such as sprouts, leaves, and microgreens.

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Ethnopharmacological Relevance: Functional dyspepsia (FD) is a prevalent gastrointestinal disorder characterised by high incidence and recurrence rates, posing significant health risks. Erpixing Granules (EPX), approved by the National Food and Drug Administration in 2002, are known for their spleen and stomach invigorating properties, effectively treating FD. However, its mechanism of action remains unclear.

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Article Synopsis
  • * DTX treatment improved health outcomes by increasing body weight and decreasing harmful compounds like serum urate levels and indicators of kidney damage, while also enhancing uric acid excretion.
  • * The study found that DTX regulates specific transport proteins in the kidneys, downregulating GLUT9 and upregulating OAT1 and OAT3, which helps slow the progression of hyperuricemia.
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As key performance indicators, the water absorption and mechanical strength of ceramics are highly associated with sintering temperature. Lower sintering temperatures, although favorable for energy saving in ceramics production, normally render the densification degree and water absorption of as-prepared ceramics to largely decline and increase, respectively. In the present work, 0.

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Black phosphorus (BP), a promising two-dimensional (2D) layered semiconductor material, has gained enormous attention due to its impressive properties over the past several years. Although plenty of methods have been developed to synthesize high-quality BP, most of the currently available BP materials still suffer from unsatisfactory crystallization, purity, and stability in air, hindering their practical application. A facile approach to synthesizing ultrahigh-quality single-crystal BP is of significance to shed light on the nature of 2D semiconductor materials and their massive application.

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The present review expounds the advancements in the application and mechanisms of flavonoids in gouty arthritis, highlighting their significance in managing the disease. Gouty arthritis is among the most common and severe inflammatory diseases, caused by hyperuricemia and the deposition of sodium urate crystals in the joints and surrounding tissues, posing a serious threat to human life and health. Flavonoids, extracted from various herbs, have attracted significant attention due to their efficacy in improving gouty arthritis.

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