Publications by authors named "Yan Tian"

Background: Effective therapeutic approaches for the treatment of diabetic nephropathy (DN) with irreversible deterioration of renal function are currently lacking. In this study, we aimed to investigate the ability of the glucagon-likepeptide-1 (GLP-1)/ gastric inhibitory polypeptide (GIP) dual agonist, tirzepatide to alleviate DN in mice and its underlying mechanisms.

Methods: We investigated the reno-protective effect of semaglutide and tirzepatide in a mouse model of DN, an insulin-treated positive control group was also included.

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  • Immune cells play a vital role in lung adenocarcinoma (LUAD) progression, yet their direct impact and the influence of plasma metabolites are still not well understood.
  • A two-step Mendelian randomization (MR) study used genetic data to explore the connections between immune cells, plasma metabolites, and LUAD, revealing a causal link between 14 immune cell traits and LUAD.
  • The study identified 9 mediating pathways influenced by 21 plasma metabolites, highlighting their potential for developing risk models and clinical biomarkers for LUAD.
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Background: The long-term stability of hepatitis B surface antigen (HBsAg) seroclearance following peginterferon alpha (peg-IFN-α)-based therapy has not been extensively studied, leaving the full potential and limitations of this strategy unclear.

Aim: To assess HBsAg recurrence after seroclearance achieved by peg-IFN-α regimens.

Methods: This prospective, multicenter, observational study was conducted from November 2015 to June 2021 at three Chinese hospitals: The Second Affiliated Hospital of Xi'an Jiaotong University, Ankang Central Hospital, and The Affiliated Hospital of Yan'an University.

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To explore the feasibility of pure yeast fermentation in whole Calamondin puree (FWCP) for the utilization of the whole fruit, yeasts were isolated from naturally fermented Calamondin, and their fermentation characteristics were evaluated. The results indicated that all yeasts were able to ferment FWCP, reducing the sour taste by degrading citric acid, increasing the contents of nutrients (such as phenols and limonins) and volatile compounds, and enhancing the antioxidant activity and inhibition of α-glucosidase activity ( < 0.05).

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Propylene glycol (PG)-mixed steam enhanced extraction is a promising remediation technique for removing semi-volatile organic compounds (SVOCs) from the unsaturated zone. However, the mechanisms of heat and moisture transfer during PG-mixed steam injection remain unclear. In this study, a 2D experimental system was developed to enable non-invasive monitoring of the spatio-temporal distribution of temperature and degree of saturation during steam injection into porous media.

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Curiosity, as the strong desire to acquire new information, plays a crucial role in human behaviors. While recent research has delved into the effects, behavioral manifestations, and neural underpinnings of curiosity, the absence of standardized assessment tools for measuring curiosity may hinder advancements in this field. Here, we translated different curiosity scales into Chinese and tested each translated scale by examining its reliability and structural validity.

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The increasing incidence of metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), in the past decade is a serious concern worldwide. Disruption of cellular protein homeostasis has been considered as a crucial contributor to the pathogenesis of metabolic diseases. To maintain protein homeostasis, cells have evolved multiple dynamic and self-regulating quality control processes to adapt new environmental conditions and prevent prolonged damage.

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  • * Most urachal cancers are classified as intestinal adenocarcinomas (90%), and they often occur in the lower urachal tube or bladder dome, leading to late diagnoses due to the silent nature of early stages.
  • * Treatment options for this aggressive cancer include surgery and chemotherapy (like cisplatin), with some patients showing positive responses to targeted therapies; a case study highlighted successful surgical treatment for a patient with advanced disease.
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Background: Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke. Tenecteplase, a recombinant human tenecteplase tissue-type plasminogen activator, is a genetically modified variant of alteplase. It is unclear whether the outcomes are different if alteplase is replaced with tenecteplase.

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Background: While percutaneous external fixation has gained popularity in transconjunctival blepharoplasty due to its simplicity and minimal incision, internal fixation remains the standard approach in transcutaneous blepharoplasty.

Objectives: This study aims to assess the safety and effectiveness of percutaneous external fixation specifically in transcutaneous fat repositioning blepharoplasty.

Methods: From May 2022 to December 2023, a consecutive cohort of 97 patients underwent this surgical technique.

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  • Restricting lipid absorption through diet and inhibiting lipase enzyme activity is seen as an effective way to manage obesity.
  • Extracts from MF and SCF fruits showed significant potential in controlling obesity in mice on a high-fat diet by blocking lipase action.
  • Citric acid and malic acid, found in MF and SCF, can prevent weight gain and related health issues, suggesting these fruits might be useful in healthy foods and supplements for obesity management.
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  • - Tungsten (W) is a toxic pollutant that harms aquatic ecosystems and human health, yet there's limited knowledge about its movement in lake sediments.
  • - A study measured concentrations of soluble W, manganese (Mn), and iron (Fe) using a special sampling device, revealing higher W levels in algae-rich areas compared to areas with aquatic plants.
  • - The competition between algae-derived organic matter and W, as well as the role of aquatic plants in W uptake and the formation of certain iron and manganese oxides, plays a significant role in controlling W release from sediments.
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  • Recent trials indicate that patients with large ischemic cores benefit more from endovascular thrombectomy (EVT) than standard medical treatment (SMT), prompting a study on how this benefit varies by occlusion location.
  • The study analyzed 745 patients with acute large vessel occlusions, assessing outcomes using the modified Rankin Scale and focusing on symptomatic intracranial hemorrhage as a safety measure.
  • Results showed better outcomes for patients with internal carotid artery and M1 segment occlusions after EVT, while the benefit for M2 segment occlusions was unclear and there was a higher risk of hemorrhage with EVT across all groups.
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Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial regulator of human physiology and pathology. Increasing evidence showcases a reciprocal relationship between ferroptosis and dysregulated metabolism, propagating a pathogenic vicious cycle that exacerbates pathology and human diseases, particularly metabolic disorders. Consequently, there is a rapidly growing interest in developing ferroptosis-based therapeutics.

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Background: Emotion analysis of social media texts is an innovative method for gaining insight into the mental state of the public and understanding social phenomena. However, emotion is a complex psychological phenomenon, and there are various emotion classification schemes. Which one is suitable for textual emotion analysis?

Methods: We proposed a framework for evaluating emotion classification schemes based on manual annotation experiments.

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Global water resources affected by excessive nitrate (NO) have caused a series of human health and ecological problems. Therefore, identification of NO sources and transformations is of pivotal significance in the strategic governance of widespread NO contaminant. In this investigation, a combination of statistical analysis, chemical indicators, isotopes, and MixSIAR model approaches was adopted to reveal the hydrochemical factors affecting NO concentrations and quantify the contribution of each source to NO concentrations in surface water and groundwater.

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  • This study developed a method using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze five key components in rat tissues after administering two different treatments, Shuganning Injection and Scutellariae Radix extract.
  • Researchers observed how the concentrations of these components changed over time in various organs, focusing on differences in distribution and effects when Scutellariae Radix was used alone or with other drugs.
  • Results showed that the five compounds were widely distributed across multiple organs, with significant differences in concentration, particularly indicating that the combination treatment led to higher levels of certain components in the heart, liver, kidney, and lung compared to using Scutellariae Radix extract alone.
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  • * Antibiotic overuse has caused multi-drug-resistant bacteria, prompting the development of a new hydrogel combining ε-polylysine and Epigallocatechin-3-gallate, which has antibacterial properties without harmful effects.
  • * The hydrogel not only effectively prevents infections in burn wounds but also promotes healing and reduces inflammation, making it a promising approach for wound care before skin grafting.
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Background: Clinical evidence of the potential influence of stress hyperglycemia ratio (SHR) for patients with large ischemic stroke whether or not receiving endovascular therapy is not clear.

Methods: This study was a subanalysis of a prospective, multicenter registry, and included 745 patients with large ischemic stroke across 38 centers in China. A total of 427 patients were included in this study, with 285 received endovascular therapy (EVT) and 142 received standard medical therapy (SMT).

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Diabetic macroangiopathy is a leading cause of diabetes-related mortality worldwide. Both genetic and environmental factors, through a multitude of underlying molecular mechanisms, contribute to the pathogenesis of diabetic macroangiopathy. MicroRNAs (miRNAs), a class of non-coding RNAs known for their functional diversity and expression specificity, are increasingly recognized for their roles in the initiation and progression of diabetes and diabetic macroangiopathy.

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  • Ovarian clear cell carcinoma typically does not respond well to second-line chemotherapy, prompting the investigation of sintilimab combined with bevacizumab as a treatment option for relapsed cases.
  • In a phase 2 trial involving 41 enrolled patients, the combination therapy led to an objective response rate of 40.5%, with 5 patients achieving complete responses and 10 partial responses.
  • The study emphasized the safety of this treatment, reporting that only 7% of patients experienced serious treatment-related side effects during the follow-up period.
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  • * An analysis of 126 cases showed no significant differences in most surgical outcomes between the two methods, but TVT-A had less postoperative groin pain.
  • * The findings suggest that while both TVT-A and TVT-O are effective for SUI, TVT-A is preferable as it is more minimally invasive and has fewer complications.
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The T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), a newly discovered checkpoint, is characterized by its elevated expression on CD4 + T cells, CD8 + T cells, natural killer (NK) cells, regulatory T cells (Tregs), and tumor-infiltrating lymphocytes (TILs). Research to date has been shown that TIGIT has been linked to exhaustion of NK cell both and T cells in numerous cancers. CD155, being the specific ligand of TIGIT in humans, emerges as a key target for immunotherapy owing to its crucial interaction with TIGIT.

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A 49-year-old woman patient with thyroid cancer accepted thyroidectomy and parathyroid transplantation. One month later, localized 131 I uptake in the deltoid muscle bilaterally was detected by 131 I whole-body imaging performed in 2 days after 131 I administration.

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