A correlation study between blood glucose fluctuation and chronic pain in the older people with type 2 diabetes mellitus.

Objectives: To investigate the correlation between blood glucose fluctuation parameters and other clinical data with chronic pain in older patients ( ≧ 60 years) with type 2 diabetes mellitus (T2DM), as well as evaluating the predictive value of risk of these parameters for chronic pain.

Methods: Clinical data were collected from 60 older patients with T2DM undergoing chronic pain who were hospitalized in the Department of Geriatric Endocrinology at the First Affiliated Hospital of Anhui Medical University. Pain scores using the numeric rating scale (NRS) were administered to all study participants by a dedicated person.

Association of triglyceride-glucose index and diabesity: evidence from a national longitudinal study.

Background: Diabesity, a co-occurrence of diabetes and obesity, is a growing public health concern globally. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with various metabolic disorders. This study aimed to investigate the association between TyG index and new-onset diabesity in a national longitudinal study.

Advances in Manganese-based nanomaterials for cancer therapy via regulating Non-Ferrous ferroptosis.

Ferroptosis, a regulated form of cell death distinct from apoptosis, was first identified in 2012 and is characterized by iron-dependent lipid peroxidation driven by reactive oxygen species (ROS). Since its discovery, ferroptosis has been linked to various diseases, with recent studies highlighting its potential in cancer therapy, particularly for targeting cancer cells that are resistant to traditional treatments like chemotherapy and radiotherapy. While iron has historically been central to ferroptosis, emerging evidence indicates that non-ferrous ions, especially manganese (Mn), also play a crucial role in modulating this process.

An epidemiological survey of bovine piroplasmosis in Kashgar, Xinjiang, China.

Piroplasmosis is an important tick-borne disease in several regions, and can lead to significant economic animal production losses. The current study aimed to systematically examine the incidence of bovine piroplasmosis in Kashgar, Xinjiang, to provide baseline data for the effective prevention and control of this disease among bovines in the region. A total of 1403 bovine blood samples from 12 sampling points were screened via PCR with universal Piroplasma primers targeting the 18S rRNA locus and specific Theileria annulata primers targeting the cytochrome b (COB) gene.

Investigating the differences of active oxygen species and carbonate species on the surface of CeM (M = Mn and Zr)O catalysts prepared by the aerosol method during CO oxidation using TPR-DRIFTS-MS.

Surface oxygen species and carbonate species play an important role in CO oxidation. However, their essential relationsh with CO oxidation activity remains unclear. In this paper, CeM (M = Mn and Zr)O catalysts are selected as the research target and TPR-DRIFTS-MS is used to investigate the changes of oxygen species and carbonate species on the catalyst surface.

Analysis of factors affecting diagnosis of unilateral isolated fungal sphenoid sinusitis.

Background: To analyze the characteristics and factors influencing the diagnosis of unilateral isolated fungal sphenoid sinusitis.

Methods: A retrospective analysis was conducted on the clinical data of patients who underwent surgery for unilateral isolated sphenoid sinusitis between June 2020 and May 2023. Data collected included variables such as gender, age, side of the specimen, symptoms, sinus computed tomography findings, pathological results, and complications.

Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

Aims: Type 2 diabetes mellitus (T2DM) is prevalent worldwide, often manageable through lifestyle changes like physical activity. This meta-analysis aimed to determine the effect of resistance training (RT) on cardiovascular risk factors in adults with T2DM.

Methods: Four databases were searched up to March 2024.

YOLO-OD: Obstacle Detection for Visually Impaired Navigation Assistance.

Visually impaired individuals frequently encounter difficulties in detecting and avoiding obstacles in the wild. To address this issue, we propose an obstacle detection method for visual navigation assistance, named YOLO-OD. To improve the ability to detect and differentiate between different sized obstacles in outdoor environments, we introduce the Feature Weighting Block (FWB), which improves feature importance discrimination.

Sexual dissatisfaction and its association with health status among older adults in China: a nationwide study.

Background Most population-based sexual health research in China excludes older adults. To fill the gap, this study aims to characterise sexual dissatisfaction among people aged 50years or older from a nationwide, population-representative sample and to explore its association with physical, mental, and self-reported overall health indicators. Methods Data were collected as part of the China Family Panel Studies in 2020, led by the Institute of Social Science Survey of Peking University.

RNA sequencing reveals dynamic expression of genes related to innate immune responses in canine small intestinal epithelial cells induced by protoscoleces.

Background: Dogs are definitive hosts of , with the small intestine being the only site of parasitic infections. However, the immunomodulatory processes that occur during interactions between and its definitive host remain unclear. Therefore, this study aimed to evaluate gene transcription patterns in canine small intestinal epithelial cells (CIECs) following stimulation by protoscoleces (PSCs).

Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia.

Objective: To investigate the effects of magnesium sulfate combined with labetalol treatment on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia (PE).

Methods: In this retrospective study, clinical data was analyzed from 262 PE parturients who were treated in Xi'an High-Tech Hospital from January 2022 to February 2024. They were divided into the experimental group (138 cases) and the control group (124 cases) based on the treatment plan.

Autoimmune side-effect of immunotherapy in lung cancer treatment revealed from large-scale cohort.

Although immune checkpoint inhibitors have illustrated strong benefits in patient survival and have been widely acknowledged in treating lung cancer, they may be subject to increased risk of immune-related adverse effects (irAEs). Although existing literature have studied the mechanisms of irAEs of immunotherapy, it is difficult to quantify such effect, especially at a large-scale real-world population level. In this paper, the autoimmune-related risk of multiple immune checkpoint inhibitors is compared with that of chemotherapy based on Medicaid and CHIP TAF (T-MSIS Analytic File) data of over 100,000 patient samples from 2012 to 2018.

Cognitive offloading bias in primary and secondary school students and its relationship with metacognitive monitoring.

Individuals often use external aids to assist with information storage, a process known as cognitive offloading. Prior research has indicated that adults sometimes fail to utilize internal and external cognitive resources judiciously, resulting in cognitive offloading bias, which is often linked to metacognition. However, it remains experimentally unverified whether primary and secondary school students exhibit cognitive offloading bias and how this relates to metacognition.

A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus.

Fructus Aurantii, a Chinese herbal medicine, has been indicated to have antidepressant effects in our previous study. However, the main component and specific mechanisms of the antidepressant effects of Fructus Aurantii still need to be further revealed. This study aimed to explore the main antidepressant component of Fructus Aurantii and the underlying mechanisms of its antidepressant effects in the hippocampus.

Co-boosted catalytic performance of polyhistidine-tagged organophosphate hydrolase locked in cobalt-organic framework.

Hydrolysis of organophosphates (OPs) with organophosphate hydrolase (OPH) provides a green approach to degrading OPs, but the success of enzymatic OPs degradation relies on the availability of high-efficiency OPH. Herein, we report a simple but effective way to constructing high-performance OPH preparations based on the in situ encapsulation of hexahistidine-tagged OPH (H-OPH) into cobaltous zeolitic imidazolate framework (ZIF-67) via biomineralization. ZIF-8 made of the same organic ligand but a different metal ion (Zn) was used for comparison.

Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.

Background: Although sex differences in coronary artery disease (CAD) risk have been observed, little is known about the role of sex hormones in CAD genetics. Accounting for sex hormone levels may help identify CAD-risk loci and extend our knowledge of its genetic architecture.

Methods And Results: A total of 365 662 individuals of European ancestry enrolled in the UK Biobank were considered.

Solar Energy-Promoted Bisphenol A Degradation with Immobilized Laccase in an FeO-Embedded Metal-Organic Framework.

Bisphenol A (BPA) is a well-recognized endocrine-disrupting chemical that poses risks to both human health and the environment. Laccase can effectively biodegrade bisphenol A, but the low environmental temperature (∼25 °C) restricts the biodegradation efficiency. In this study, the enzyme laccase and FeO with solar-thermal conversion capability were coimmobilized into zeolitic imidazolate framework-8 (Lac@ZIF-8-FeO) to facilitate efficient biodegradation of bisphenol A under simulated solar irradiation.

Reversibility of polystyrene nanoplastics-induced disruption of testosterone biosynthesis in mice: The role of histone modifications.

Nanoplastics (NPs) exposure could disrupt the synthesis of steroid hormones, thereby posing a potential threat to male reproductive health. However, the existing comprehension of the molecular mechanisms participating in this process remains limited, and the reversibility of NPs-triggered male reproductive toxicity is poorly understood. This investigation focused on the impact of histone modification on testosterone production in mice under long-term exposure to environmentally relevant doses of polystyrene nanoplastics (PS-NPs).

Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China.

Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.

Associations of motor and neuropsychiatric symptoms with comorbidities in prodromal Parkinson's disease.

Objective: To investigate the associations between comorbidities and multimorbidity patterns with motor and neuropsychiatric symptoms in patients with Parkinson's disease (PD) in prodromal PD.

Methods: Multimorbidity is defined as the coexistence of two or more long-term conditions (LTCs) (also known as multiple comorbidities). A total of 921 participants without PD were included in the Parkinson's Progression Markers Initiative (PPMI) database and were categorized according to the LTC count.

Identification of a novel mutation in gene associated with the germinal vesicle arrest of oocytes.

The aim of this study was to investigate the genetic factors of a patient with germinal vesicle arrest in oocytes. Clinical data and blood samples were collected from the patient and some were amplified for high-throughput gene and Sanger sequencing. Several molecular and cellular experiments were performed to determine the association between the gene mutation and germinal vesicle arrest.

The activation of microglia by the complement system in neurodegenerative diseases.

Neurodegenerative diseases (NDDs) are a group of neurological disorders characterized by the progressive loss of neuronal structure and function, leading to cognitive and behavioral impairments. Despite significant research advancements, there is currently no definitive cure for NDDs. With global aging on the rise, the burden of these diseases is becoming increasingly severe, highlighting the urgency of understanding their pathogenesis and developing effective therapeutic strategies.

A study on the intervention effect of a case management model that breaks through spatiotemporal characteristics in home-based phase II exercise rehabilitation post PCI.

Objective: This study aims to explore the effect of a case management model that breaks through the temporal and spatial characteristics on the at-home phase II exercise rehabilitation of postoperative patients treated with percutaneous coronary intervention (PCI).

Methods: We used the convenience sampling method to select 103 patients with coronary artery disease (53 in the observation group and 50 in the control group) who were admitted to the Department of Cardiovascular Internal Medicine at the Jiaxing No. 2 Hospital in January 2022 and January 2023 and underwent PCI treatment as study subjects.