Publications by authors named "Yan Song Liu"

Background: Spontaneous thought is a universal, complex, and heterogeneous cognitive activity that significantly impacts mental activity and strongly correlates with mental disorders.

Methods: Utilizing the think-aloud method, we captured spontaneous thoughts during rest from 38 diagnosed with depression, alongside 36 healthy controls and 137 healthy individuals. Through a comprehensive assessment of various dimensions of thought content, we compared thought content between individuals with depression and healthy controls, and between healthy women and men.

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Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned cortical vulnerability. Here, we initially examined voxel-wise differences in cortical function and structure using the largest multi-modal MRI data from 1660 MDD patients and 1341 controls.

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  • This study investigates the combined effects of alcohol dependence and obesity on the brain's white matter microstructure, using diffusion tensor imaging (DTI).
  • It included 60 alcohol-dependent inpatients and 65 control subjects to compare their white matter measurements.
  • Findings indicate that while obesity alone didn't show significant differences in DTI measures between groups, alcohol-dependent individuals who were overweight/obese exhibited notable reductions in fractional anisotropy (FA) and increases in radial diffusivity (RD), suggesting these factors interact to affect brain structure.
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  • * IL-12 is a powerful cytokine that improves T-cell activation and has strong anti-tumor effects, but it can also cause serious side effects.
  • * The combination of Mn and IL-12 shows improved anti-tumor effects and better safety, suggesting a promising new strategy for effective and safer cancer treatment.
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  • The study aims to enhance the assessment of cervical maturity in Chinese women undergoing labor induction by integrating ultrasound data and machine learning with the traditional Bishop scoring method.
  • Researchers trained and tested a machine learning model using data from 101 pregnant women to predict the time from labor induction to actual labor, comparing the accuracy of different machine learning algorithms like XGBoost, CatBoost, and Random Forest against the Bishop method.
  • Findings showed that the machine learning models, especially XGBoost, significantly reduced prediction errors compared to the Bishop method, suggesting a more objective and accurate approach for evaluating cervical maturity.
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Rumination is closely linked to the onset and maintenance of major depressive disorder (MDD). Prior neuroimaging studies have identified the association between self-reported rumination trait and the functional coupling among a network of brain regions using resting-state functional magnetic resonance imaging (MRI). However, little is known about the underlying neural circuitry mechanism during active rumination in MDD.

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  • Identifying biomarkers to predict relapse in alcohol dependence is crucial but difficult; researchers used neuroimaging to tackle this issue.
  • A study involved 66 male patients in early abstinence who underwent brain imaging and were monitored for 6 months.
  • The use of relevance-vector-machine analysis led to a predictive model that distinguished relapsing patients from those who remained abstinent, achieving high accuracy and a strong area under the curve.
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Detection and recovery of audio signals using optical methods is an appealing topic. Observing the movement of secondary speckle patterns is a convenient method for such a purpose. In order to have less computational cost and faster processing, one-dimensional laser speckle images are captured by an imaging device, while it sacrifices the ability to detect speckle movement along one axis.

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Background: Bone cancer pain (BCP) is the most severe and intractable type of cancer pain. Emerging evidence has demonstrated that activated microglia in the spinal cord could release a series of neurotoxic substances to stimulate neurons and form neuronal sensitization. The P2X7 receptor (P2X7R) is a nonselective ATP-gated ion channel predominantly present in microglia in the spinal cord as the key modulator of microglial activity.

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Objective: To investigate the short-term effect of music therapy combined with binaural frequency difference therapy on patients with consciousness disorder.

Materials And Methods: Ninety patients with definite diagnosis of disorders of consciousness (DOC) were selected. These patients were randomly divided into control group, experiment 1 group and experiment 2 group, with 30 patients in each group.

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The fabrication of van der Waals (vdWs) heterostructures mainly extends to two-dimensional (2D) materials. Nevertheless, the current processes for obtaining high-quality 2D films are mainly exfoliated from their bulk counterparts or by high-temperature chemical vapor deposition (CVD), which limits industrial production and is often accompanied by defects. Herein, we first fabricated the type-II p-PdSe/n-InSe vdWs heterostructure using the ultra-high vacuum laser molecular beam epitaxy (LMBE) technique combined with the vertical 2D stacking strategy, which is reproducible and suitable for high-volume manufacturing.

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  • A study was conducted to assess the impact of combining pulmonary rehabilitation with diaphragm pacemaker therapy on diaphragm function in patients who are severely ill and on mechanical ventilation.
  • 40 patients were split into two groups: one received standard care (control group), while the other (experimental group) received additional diaphragm pacemaker therapy along with standard care.
  • Results showed that after 30 days, the experimental group had more significant improvements in health indicators and shorter hospital stays compared to the control group, with no adverse events reported.
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Objective: The objective of this study was to investigate the clinical efficacy of hyperbaric oxygen combined with right median-nerve stimulation (RMNES) in patients with disorders of consciousness caused by brain injury.

Methods: A total of 120 patients with consciousness disorders caused by brain injury were selected. They were randomly divided into three groups, a control group, test group 1 (treated with RMNES after hyperbaric oxygen therapy [HBOT]), and test group 2 (treated with RMNES at the same time as HBOT), with 40 patients in each group.

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  • Despite advancements in neuroimaging research on major depressive disorder (MDD), findings remain inconsistent due to small sample sizes and varying analysis methods, prompting the launch of the Depression Imaging REsearch ConsorTium (DIRECT) and the REST-meta-MDD project, which pooled data from 2,428 functional brain images.
  • The initial analyses revealed significant changes in brain connectivity and dynamics, laying the groundwork for future research and highlighting the need for more comprehensive studies across diverse populations.
  • DIRECT's second phase aims to broaden the investigation of brain alterations in MDD by including various ethnic groups and other mental health disorders, while also focusing on long-term studies of treatment effects and improving neuroimaging methodologies for clinical applications.
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  • The study investigates the nucleus accumbens (NAc), which is key in reward processing and its role in major depressive disorder (MDD).
  • Through meta- and mega-analysis of resting-state fMRI data, it was found that patients with recurrent MDD exhibited decreased functional connectivity within the NAc-based reward circuits.
  • The research highlights that disrupted connectivity between the reward network and the default mode network (DMN) may aid in differentiating MDD patients from healthy individuals, suggesting potential biomarkers for diagnosis.
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  • - Researchers studied brain activity using resting-state fMRI to identify potential biomarkers that could predict relapse in individuals with alcohol dependence during early abstinence.
  • - The study involved 68 alcohol-dependent participants and 68 healthy controls, comparing brain activity patterns and finding significant differences in certain brain regions linked to alcohol addiction.
  • - Findings revealed that specific brain connectivity and activity reductions were associated with both alcohol dependence and relapse, with certain metrics showing good predictive capabilities for relapse risk.
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Background: Internet addiction (IA) is associated with adverse consequences, especially for younger people. Evidence indicates that IA is associated with depression, but no studies have yet investigated potential common vulnerability between them.

Methods: IA (measured by the Young's 20-item Internet Addiction Test Scale) and depressive symptoms (measured by the Patient Health Questionnaire-9 Scale) among 12 043 undergraduates were surveyed at baseline and at a respective 12 month follow-up for each participant.

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Background: Acute kidney injury (AKI) is one of the most common acute pancreatitis (AP)-associated complications that has a significant effect on AP, but the factors affecting the AP patients' survival rate remains unclear.

Aim: To assess the influences of AKI on the survival rate in AP patients.

Methods: A total of 139 AP patients were included in this retrospective study.

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  • The study investigates the alterations in functional homotopy architecture in patients with Major Depressive Disorder (MDD), highlighting a significant reduction in functional connectivity between homotopic brain regions.
  • Using resting-state fMRI data from over 1,000 MDD patients and nearly 900 healthy controls, researchers found specific areas in the brain, like the posterior cingulate gyrus and precuneus, showed notably decreased connectivity in MDDs, with variations related to age and gender.
  • The findings suggest that structural connectivity deficits in MDD may impact how information is exchanged between the brain's hemispheres, correlating with the severity of depressive symptoms and indicating potential areas for further study in treatment.
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  • - The study examined how patients' beliefs about medication before treatment impact their response to antidepressants in 97 inpatients with first-diagnosed depression over an eight-week period.
  • - Findings revealed that while both groups experienced decreased depression symptoms, those who achieved remission had significantly higher baseline medication beliefs compared to those who did not remit.
  • - Additionally, lower medication belief scores at the start were identified as a risk factor for poorer antidepressant efficacy, suggesting that beliefs about medication can influence treatment outcomes.
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  • * Researchers employed graph theory methods to analyze functional brain networks, finding that MDD patients exhibited significantly decreased global and local efficiency compared to normal controls.
  • * The results highlighted specific disruptions in critical brain networks, particularly affecting recurrent MDD patients, indicating a consistent pattern of impaired efficiency in both local and global brain network communication.
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Background: It is widely acknowledged that childhood adversities (CAs) and recent stress are potential risk factors for adult depression. However, the mechanism(s) by which interactions of CAs with recent stress affect adult depression remain unclear.

Aims: To investigate the predictive association of the interaction among CAs and recent stress with early-adult depression.

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  • This study aims to investigate the neural underpinnings of gastrointestinal (GI) symptoms in patients with major depressive disorder (MDD) by examining changes in brain structure, specifically focusing on gray matter volume (GMV) and density (GMD).* -
  • Researchers divided participants into three groups: MDD patients with GI symptoms, MDD patients without GI symptoms, and healthy controls, analyzing MRI scans from a total of 930 individuals and using tools like the Hamilton Depression Rating Scale to assess symptoms.* -
  • Results showed that patients with GI symptoms had higher depression scores and significant differences in brain structure compared to the other groups, particularly in regions like the superior temporal gyrus and caudate nucleus, suggesting a link between
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  • The study investigates brain functional connectivity asymmetry in patients with Major Depressive Disorder (MDD) using resting-state fMRI data from 753 patients compared to 451 healthy controls.
  • Results show that MDD patients exhibited increased asymmetry scores, indicating decreased specialization in various brain networks, particularly in the default mode, control, and attention networks, influenced by demographic and clinical variables.
  • The findings suggest that MDD disrupts efficient brain information processing, providing new insights into the pathophysiology of depression that could inform future research.
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Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.

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