Liposome-loaded miR-34c-5p attenuates apoptosis and oxidative stress following hypoxia-ischemia brain damage in neonatal mice by targeting Arhgap26.

Neonatal hypoxia-ischemia (HI) brain injury is considered a major cause of neonatal mortality and chronic disease morbidity worldwide. Despite its clinical importance, therapeutic options for HI injury remain limited. Here we demonstrated that miR-34c-5p expression peaks at postnatal day 10 in mice.

Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice.

Current treatments for ischemic stroke aim to achieve rapid reperfusion with intravenous thrombolysis and/or endovascular thrombectomy, which have proven to attenuate disability. Despite the significant progress in reperfusion therapies, functional recovery remains inconsistent, primarily due to ongoing neuronal excitotoxicity and neuroinflammation. In this study we investigated the relationship between neuronal activity and neuroinflammation in an ischemic mouse model using chemogenetic techniques.

Predictive value of magnetic resonance imaging parameters combined with tumor markers for rectal cancer recurrence risk after surgery.

Background: An increasing number of studies to date have found preoperative magnetic resonance imaging (MRI) features valuable in predicting the prognosis of rectal cancer (RC). However, research is still lacking on the correlation between preoperative MRI features and the risk of recurrence after radical resection of RC, urgently necessitating further in-depth exploration.

Aim: To investigate the correlation between preoperative MRI parameters and the risk of recurrence after radical resection of RC to provide an effective tool for predicting postoperative recurrence.

Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach.

There remains a debate over the health-based guidance value of bisphenol A (BPA) worldwide. Through the weight of evidence approach, this study systematically searched and evaluated the updated BPA toxicological data following the guidelines for evaluating the relevance and reliability of toxicological data developed by the China National Center for Food Safety Risk Assessment. Benchmark dose and no observed adverse effect dose/lowest observed adverse effect level methods were used for dose-relationship analysis.

sp. nov., isolated from the China Space Station.

Understanding the characteristics of microbes during long-term space missions is essential for safeguarding the health of astronauts and maintaining the functionality of spacecraft. In this study, a Gram-positive, aerobic, spore-forming, rod-shaped strain JL1B1071 was isolated from the surface of hardware on the China Space Station. This strain belongs to the genus , with its closest relative being ATCC 4513.

A robust deep learning model for predicting green tea moisture content during fixation using near-infrared spectroscopy: Integration of multi-scale feature fusion and attention mechanisms.

Fixation is a critical step in green tea processing, and the moisture content of the leaves after fixation is a key indicator of the fixation quality. Near-infrared spectroscopy (NIRS)-based moisture detection technology is often applied in the tea processing industry. However, temperature fluctuations during processing can cause changes in the NIRS curves, which in turn affect the accuracy of moisture prediction models based on the spectral data.

Impact of Dry Age-Related Macular Degeneration on Daily Activities and Quality of Life: Interview Findings From Patients and Caregivers Relative to a General Population.

Purpose: To investigate impacts of dry age-related macular degeneration (AMD) on patients and caregivers.

Patients And Methods: Semi-structured interviews were conducted with patients with dry AMD, caregivers, and controls (individuals without dry AMD, of similar age, sex, and comorbidity profile to patients) between March 2021 and June 2023. Patients aged ≥50 years, with a best corrected visual acuity (BCVA) score from the most recent eye exam after dry AMD diagnosis, were enrolled from the US and UK.

Phase II study with sorafenib plus radiotherapy for advanced HCC with portal and/or hepatic vein tumor thrombosis.

Background & Aims: Portal and hepatic vein tumor thrombosis is associated with inferior outcomes in patients with hepatocellular carcinoma (HCC), and systemic treatment alone is often insufficient. This phase II trial evaluated the efficacy and safety of combining sorafenib with radiotherapy in advanced HCC with thrombosis.

Methods: Registered at ClinicalTrials.

C3 glomerulopathy associated with mycoplasma pneumoniae infection and positive IgA staining.

Background: Patients with C3 glomerulopathy (C3G) often have a history of infection, which implies that infection may lead to abnormal activation of the complement alternative pathway (CAP) and induce the development of C3G. However, patients with postinfectious glomerulonephritis (PIGN) often have a low serum C3 concentration and positive glomerular C3 staining, consistent with the activation of the CAP. PIGN, especially if it involves simultaneous IgA deposition, is often difficult to differentiate from C3G.

Sodium alginate and hydroxypropyl methylcellulose hierarchical control of surface tension on silk fabrics for clean and efficient inkjet printing.

Silk is widely utilized in high-end fashion apparel, home textiles and other fields due to its excellent comfort and air permeability and moisture permeability. However, inkjet printing on silk typically requires two printings on the front and back side to obtain a good color performance, leading to high process cost and low efficiency. Herein, clean and efficient inkjet printing is achieved using hydroxypropyl methylcellulose/sodium alginate (HPMC/SA) graded to regulate the surface tension of silk.

Assessing the mediating role of self-disclosure between mental health literacy and psychological distress: a cross-sectional study among HIV-positive young and middle-aged men who have sex with men in China.

Objective: To investigate the associations between mental health literacy (MHL), self-disclosure and psychological distress among HIV-positive young and middle-aged men who have sex with men (MSM). We hypothesised that self-disclosure would mediate the relationship between MHL and psychological distress.

Design: A cross-sectional study.

Newer Glucagon-Like Peptide-1 Receptor Agonists Are Associated With Improved Glycemic Control in US Adults With Type 2 Diabetes: A Population-Level Time Series Analysis.

Objectives: The population-level impact of newer glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatments on patients with type 2 diabetes remains unclear. Therefore, this study investigated the association of newer GLP-1 RAs with population-level diabetes-related outcomes in US adults with type 2 diabetes.

Methods: This was a noninterventional, retrospective analysis of administrative insurance claims data obtained from Optum's deidentified Clinformatics® Data Mart Database between January 2004 and December 2022.

NCAPD3-mediated ferroptosis of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells.

Objective: Non-SMC condensin II complex subunit D3 (NCAPD3) has recently been demonstrated as a crucial oncogenic factor, nevertheless, the biological role of NCAPD3 in the pathogenesis of breast cancer has not been elucidated. Evidence suggests that targeting ferroptosis can inhibit the progression of breast cancer. Moreover, 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) could modulate MCF-7 cell proliferation in our previous study.

The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy.

Thyroid-associated ophthalmopathy (TAO) is a vision-threatening autoimmune disease that involves the extraocular muscles (EOMs) and periorbital fat. Typical signs of TAO include eyelid recession, proptosis, diplopia, and decreased visual acuity. As a self-limited disease, there is major bipolarity in clinical outcomes in TAO population.

Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis.

Background And Aims: Multiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. This approach has received considerable attention from researchers over the past decades. This article aims to provide a bibliometric analysis of the research progress and perspectives on the application of TSA-based mIHC/IF.

Interaction, diagnosis, and treatment of lung microbiota-NLRP3 inflammasome-target organ axis in sepsis.

Sepsis is defined as a life-threatening condition caused by a dysregulated host response to infection, leading to multi-organ dysfunction, and representing a significant global health burden. The progression of sepsis is closely linked to disruptions in lung microbiota, including bacterial translocation, impaired barrier function, and local microenvironmental disturbances. Conversely, the worsening of sepsis exacerbates lung microbiota imbalances, contributing to multi-organ dysfunction.

Rapid On-Site and Sensitive Detection of Microplastics Using Zirconium(IV)-Assisted SERS Label.

Microplastics have emerged as significant pollutants in terrestrial and marine ecosystems, with their accumulation posing a threat to human health through biomagnification along the food chain. Developing a rapid, on-site, and sensitive method for detecting microplastics in agri-food and environmental systems is important for assessing and minimizing their potential risks. In this study, we developed a novel surface-enhanced Raman spectroscopy (SERS) technique for the rapid, on-site, and ultrasensitive detection of microplastics.

Image reconstruction for compressed ultrafast photography based on manifold learning and the alternating direction method of multipliers.

Compressed ultrafast photography (CUP) is a high-speed imaging technique with a frame rate of up to ten trillion frames per second (fps) and a sequence depth of hundreds of frames. This technique is a powerful tool for investigating ultrafast processes. However, since the reconstruction process is an ill-posed problem, the image reconstruction will be more difficult with the increase of the number of reconstruction frames and the number of pixels of each reconstruction frame.

Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.

Hypoxia ischemia (HI) is a leading cause of cerebral palsy and long-term neurological sequelae in infants. Given that mitochondrial dysfunction in neurons contributes to HI brain damage, this study aimed to investigate the regulatory role of miR-9-5p in mitochondrial function following HI injury. Overexpression of miR-9-5p in HI mice or HO-exposed PC12 cells suppressed neuronal injury, associated with increased mitochondrial copy number, normalizing mitochondrial membrane potential, improved nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activation, and downregulation of Keap1.

Exploring the effects of aromatherapy and acupoint herbal patching on fatigue and sleep disorders in people living with HIV: a pilot randomized trial.

The purpose of this study was to investigate the effects of aromatherapy and acupoint herbal patching on fatigue and sleep disorders in people living with HIV (PLWH). Aromatherapy and acupoint herbal patching are ancient alternative therapies in traditional Chinese medicine. We randomly selected 90 patients from the Nanjing Public Health Medical Center in China and divided them into three groups: aromatherapy group, acupoint herbal patching group and control group.

Porous carbon nanosheets integrated with graphene-wrapped CoO and CoNx as efficient bifunctional oxygen electrocatalysts for rechargeable zinc-air batteries.

The development of advanced bifunctional oxygen electrocatalysts for the oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) is crucial for the practical application of zinc-air batteries (ZABs). Herein, porous carbon nanosheets integrated with abundant graphene-wrapped CoO and CoNx (CoO/CoNx-C) were successfully fabricated through a simple one-step pyrolysis. With convenient porous channel and large accessible surface, abundant CoO/CoNx species and graphene wrapping structure, CoO/CoNx-C exhibited a half-wave potential of 0.

Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Salt and Drought Stress in .

The basic leucine zipper (bZIP) transcription factors play essential roles in multiple stress responses and have been identified and functionally characterized in many plant species. However, the bZIP family members in blueberry are unclear. In this study, we identified 102 genes in .

Ursonic Acid Ameliorates HO-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.

Growing evidence suggests that plant compounds are emerging as a tremendous source for slowing the onset and progression of Alzheimer's disease (AD). Ursonic acid (UNA) is a naturally occurring pentacyclic triterpenoid with some hypoglycemic, anticancer, and antiinflammatory activities. However, the pharmacological effects of UNA on AD are still unknown.

Multipath joint ablation strategy for focal atrial tachycardia originating from patent foramen ovale: a case report.

Introduction: Focal atrial tachycardia (FAT) is predominant in the pediatric population. Recent research has identified cases of sustained FAT originating from the interatrial septum (IAS); a subset of cases presents a unique challenge, with foci originating from the peri-patent foramen ovale (peri-PFO), requiring specialized management during catheter ablation. Here, we present a rare case of peri-PFO-associated FAT that resulted in tachycardia-related cardiomyopathy and propose a comprehensive multipath joint strategy for the successful treatment of PFO-associated FAT.