Publications by authors named "Yan Shuang Song"
[Evidence-based study of chromate exposed workers' health surveillance indexes].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2013
Objective: The health surveillance proposal for chromate exposed workers was provided and analyzed on the evidence-based study and then to be improved.
Method: Firstly, the related literatures were searched about liver damage, micronuclei, urinary chromium and hexavalent chromium exposure in Evidence Based Medicine Reviews such as Cochran library, OVID Medline, Web of knowledge in December 2011; and then, these literatures were reviewed in according to inclusion and exclusion criteria; 22 articles totally were retrieved, evaluated and classified in according to the grading standard by Oxford Centre for Evidence-based Medicine.Finally, field epidemiological investigation was further adopted to confirm the efficiency and feasibility of this proposal, combined with cost-effectiveness analysis:the ratio of total cost divided survival years was used to express the cost-effectiveness.
Both hexavalent chromium [Cr (VI)] exposure and folate deficiency have been associated with increased cancer risks. Our previous studies have found folate deficiency in Cr (VI) exposed population. Here the relationship between some tumor markers and folate status in long-term Cr (VI) exposure was investigated carefully to show the multiple aspects of Cr (VI) carcinogenesis.
View Article and Find Full Text PDF[Impact of specimen collection and storage consumable products on trace element quantitative analysis].
Zhonghua Yu Fang Yi Xue Za Zhi
July 2012
Article Synopsis
- The study investigated how different brands of specimen collection and storage products affect the accuracy of trace element analysis in samples.
- Various collection devices and consumables were tested for their potential contamination by elements like cadmium, copper, and zinc using advanced measurement techniques.
- Results showed varying levels of background element concentrations, with some brands exhibiting higher contamination, particularly in urine and blood sampling devices, which could impact the reliability of test results.
[Effect of occupational combined exposure of chromium and iron on erythrocyte metabolism].
Zhonghua Yu Fang Yi Xue Za Zhi
April 2012
Objective: To investigate the effect of combined occupational exposure of chromium and iron on erythrocyte metabolism, and the possible mechanism.
Methods: A total of 115 chromate production workers were selected in a chemical factory of Jinan as exposure group, Dec, 2008, and 60 healthy residents from a community which was far away from the factory were enrolled as control group. Environmental concentrations of chromium and iron were collected by filter membrane sampling and determined.
[Dynamic observation of pulmonary ventilation function in workers contacting chromate].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2012
Article Synopsis
- The study aimed to investigate the impact of chronic chromate exposure on the pulmonary ventilation function of workers in a chromate manufacturing factory in Henan Province, comparing them to a control group without exposure.
- Results from 2010 and 2011 showed significant decreases in vital lung function measurements (like FVC and FEV1) among the chromate-exposed workers compared to the control group, indicating negative effects on respiratory health.
- Despite the observed declines, the classification of pulmonary dysfunction among both groups remained similar, primarily categorized as "limit type," suggesting that the extent of dysfunction didn't change significantly over the exposure period.
Article Synopsis
- - Exposure to hexavalent chromium [Cr (VI)] can lead to DNA damage and increase cancer risk, while folate deficiency affects DNA stability and methylation.
- - A study of 115 chromate workers found higher chromium levels in their blood and lower serum folate compared to 60 unexposed local residents.
- - The reduced folate levels in workers were linked to increased DNA damage, suggesting that folate supplements could help stabilize genetic material and lower cancer risk for those exposed to chromium.
The detrimental effect of chronic chromium (Cr) exposure on the prostate has never been studied. Here, we report the prostate specific antigen (PSA) changes in occupational chromate exposed workers. In this study, eighty six male occupational chromate exposed workers and forty five age-matched controls were recruited.
View Article and Find Full Text PDFObjectives: Chronic occupational exposure to chromium can result in a broad range of adverse effects including multiple organ damage, genotoxicity and carcinogenesis. However, the metabolic consequences of chromium exposure have not been fully investigated. This study was designed to examine vitamin B12, folate and homocysteine metabolic changes in workers chronically exposed to chromate.
View Article and Find Full Text PDFPurpose: Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma.
Patients And Methods: We measured single nucleotide polymorphisms in the metabolizing, detoxifying, and DNA repair pathways in 120 newly diagnosed patients with soft tissue sarcoma.